Serum Mannose-Binding Lectin Is a Strong Biomarker of Diabetic Retinopathy in Chinese Patients With Diabetes

Abstract

OBJECTIVEInflammation and complement activation initiated by mannose-binding lectin (MBL) may be implicated in the pathogenesis of diabetic vascular complications. We investigated serum MBL levels in patients with diabetes with and without diabetic retinopathy (DR). RESEARCH DESIGN AND METHODSSerum MBL levels were determined in 348 patients with diabetes and in 100 healthy control subjects. The prediction value of MBL was compared with diabetes duration, hs-CRP, and other known predictors. Multivariate analyses were performed using logistic regression models. RESULTSMBL levels on admission were significantly increased in patients with diabetes with DR (P < 0.0001) and vision-threatening DR (VTDR; P < 0.0001). Multivariate logistic regression analysis adjusted for common indictors showed that serum MBL levels ‡3,385 mg/L were an independent predictor of DR (odds ratio [OR] 3.14, 95% CI 1.77-5.57) and VTDR (OR 7.83,). The area under the receiver operating characteristic curve of MBL was 0.81 (95% CI 0.76-0.86) for DR and 0.84 (95% CI 0.74-0.93) for VTDR. CONCLUSIONSThe current study demonstrated that MBL appears to be an independent biomarker for DR in the Chinese population, suggesting a possible role of MBL in the pathogenesis of DR complications in diabetes.Diabetes has become a major public health problem in China. In 2009, the agestandardized prevalence of diabetes was 9.7%, accounting for 92.4 million adults with diabetes (1). Diabetic retinopathy (DR) is the leading cause of blindness among working-aged adults around the world (2). Approximately 29% of U.S. adults with type 2 diabetes have DR (3), whereas DR will develop in 95% of individuals with type 1 diabetes during their lifetime (4).The presence of DR was associated with an increased risk of all-cause mortality and cardiovascular events in patients with diabetes (5). However, risk of vision loss due to DR retinopathy can be reduced by effective control of serum glucose and blood pressure (BP). The efficacy and cost-effectiveness of early detection and treatment of DR is well established (6). Although the major risk factors for

Genetic polymorphisms of C-type lectin receptors in Behcet’s disease in a Chinese Han population

“…Many studies showed that a low or high serum MBL level is involved in several immune mediated diseases (e.g., RA, Crohn’s disease, Sjögren disease and diabetic retinopathy 22–24 ). Immune defense function of MBL is associated with its serum level and oligomeric type 23 .…”

The influence of rare variants in circulating metabolic biomarkers

“…Metabolic measurements reflect an individual's endogenous biochemical processes and environmental exposures [1,2]. Many circulating lipids, lipoproteins and metabolites have been previously implicated in the development of cardiovascular disease (CVD) [3][4][5][6] or used as biomarkers for disease diagnosis or prognosis [7,8]. Understanding the genetic influence on circulating levels of these metabolic biomarkers can help us gain insight into the biological processes regulating these traits, lead to improved aetiological understanding of CVD and identify novel potential therapeutic drug targets.…”

The influence of rare variants in circulating metabolic biomarkers

“…Metabolic measurements reflect an individual’s endogenous biochemical processes and environmental exposures [1,2]. Many circulating lipids, lipoproteins and metabolites have been previously implicated in the development of cardiovascular disease (CVD) [3-6] or used as biomarkers for disease diagnosis or prognosis [7,8]. Understanding the genetic influence on circulating levels of these metabolic biomarkers can help us gain insight into the biological processes regulating these traits, lead to improved aetiological understanding of CVD and identify novel potential therapeutic drug targets.…”