Serum markers for prediction of spontaneous preterm delivery in preterm labour

Kim, Mina; Lee, Byung Seok; Park, Yong-Won; Seo, Kap-Ho

doi:10.1111/j.1365-2362.2011.02469.x

Cited by 51 publications

(56 citation statements)

References 32 publications

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“…However, this finding is difficult to apply in clinical settings because the measurement of IL-6 is time-consuming and requires a special detection kit. Other previous studies suggested the combination of the NLR and cervix length as a more sensitive marker for the prediction of preterm birth [21]. In this study, increased CRP levels and DNI values and decreased lymphocyte counts showed significant associations with HCA.…”

Section: Discussionsupporting

confidence: 63%

“…The lymphocyte count slightly decreased in the PPROM with HCA group, and this result is similar to that reported previously. The NLR is being increasingly used as a predictive marker for spontaneous preterm birth and intrauterine infection in preterm delivery [21, 31]. The NLR increased in the PPROM with HCA group, but only the lymphocyte count showed a relatively high difference between the two groups.…”

Section: Discussionmentioning

confidence: 99%

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The Delta Neutrophil Index as a predictive marker of histological chorioamnionitis in patients with preterm premature rupture of membranes: A retrospective study

et al. 2017

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BackgroundHistological chorioamnionitis (HCA) is related to perinatal morbidity. However, there is no definite diagnostic method for detecting chorioamnionitis before delivery.MethodsWe evaluated whether the delta neutrophil index (DNI) was an effective early marker of HCA in patients with preterm premature rupture of membranes (PPROM). We retrospectively evaluated 149 women diagnosed with PPROM (gestational age, 20+0 to 36+6 weeks) at Severance Hospital from January 2013 to December 2014. The women were categorized into the following two groups: (a) PPROM without HCA and (b) PPROM with HCA. The maternal white blood cell (WBC) count, neutrophil-to-lymphocyte ratio (NLR), C-reactive protein (CRP) level, and DNI were measured at admission. The DNI has been reported to reflect the fraction of circulating immature granulocytes associated with infection.ResultsOf the 149 patients, 87 were included in the PPROM without HCA group and 62 were included in the PPROM with HCA group. The interval between admission and delivery was significantly shorter in the PPROM with HCA group than in the PPROM without HCA group. There was no significant difference in the maternal WBC count. The serum CRP level, NLR, and DNI were significantly lower in the PPROM without HCA group than in the PPROM with HCA group, while the lymphocyte count was significantly lower in the PPROM with HCA group than in the PPROM without HCA group. A predictive equation was generated by combining the DNI, lymphocyte count, and CRP level, and the sensitivity and specificity for predicting a placental inflammatory response were 69.1% and 70.5%, respectively.ConclusionsThe DNI could be a predictive marker for HCA in patients with PPROM. Our predictive equation involving the DNI, lymphocyte count, and CRP level may be helpful for predicting the placental inflammatory response in patients with PPROM.

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Section: Discussionsupporting

confidence: 63%

Section: Discussionmentioning

confidence: 99%

The Delta Neutrophil Index as a predictive marker of histological chorioamnionitis in patients with preterm premature rupture of membranes: A retrospective study

et al. 2017

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“…c-reactive protein, neutrophil count, inflammatory cytokines) or genotype, which have been previously correlated in some groups of women with SPTB. 16–19 …”

Section: Commentmentioning

confidence: 99%

The phenotype of spontaneous preterm birth: application of a clinical phenotyping tool

Manuck

Esplin

Biggio

et al. 2015

American Journal of Obstetrics and Gynecology

112

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Objective Spontaneous preterm birth (SPTB) is a complex condition that is likely a final common pathway with multiple possible etiologies. We hypothesized that a comprehensive classification system could appropriately group women with similar STPB etiologies, and provide an explanation, at least in part, for the disparities in SPTB associated with race and gestational age at delivery. Study Design Planned analysis of a multicenter, prospective study of singleton SPTB. Women with SPTB < 34 weeks were included. We defined 9 potential SPTB phenotypes based on clinical data, including infection/inflammation, maternal stress, decidual hemorrhage, uterine distention, cervical insufficiency, placental dysfunction, premature rupture of the membranes, maternal comorbidities, and familial factors. Each woman was evaluated for each phenotype. Delivery gestational age was compared between those with and without each phenotype. Phenotype profiles were also compared between women with very early (20.0–27.9 weeks) SPTB vs. those with early SPTB (28.0–34.0 weeks), and between African-American and Caucasian women. Statistical analysis was by t-test and chi-square as appropriate. Results The phenotyping tool was applied to 1025 women with SPTB who delivered at a mean 30.0 (+/− 3.2) weeks gestation. Of these, 800 (78%) had ≥2 phenotypes. Only 43 (4.2%) had no phenotypes. The 281 women with early SPTB were more likely to have infection/inflammation, decidual hemorrhage, and cervical insufficiency phenotypes (all p≤0.001). African-American women had more maternal stress and cervical insufficiency but less decidual hemorrhage and placental dysfunction compared to Caucasian women (all p<0.05). Gestational age at delivery decreased as the number of phenotypes present increased. Conclusions Precise SPTB phenotyping classifies women with SPTB and identifies specific differences between very early and early SPTB and between African-Americans and Caucasians.

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“…These markers also increase in different obstetric conditions such as spontaneous preterm delivery or gestational diabetes mellitus (17,24,29,30). Studies investigating the relationship between inflammation and HG are primarily focused on the inflammatory markers in the first trimester because HG predominantly occurs in this period.…”

Section: Discussionmentioning

confidence: 99%

The Existence of Continuous Systemic Inflammation in Pregnant Women with Hyperemesis Gravidarum

Yıldırım¹,

Çendek²,

Desdicioğlu³

et al. 2017

Cyprus J Med Sci

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BACKGROUNDTo evaluate the serum inflammatory markers in the first trimester in which hyperemesis gravidarum (HG) usually occurs and in the late second trimester when symptoms of HG usually resolve. MATERIALS and METHODSThe study population consisted of 170 pregnant women with HG and 185 healthy gestational-age-matched controls. White blood cell count (WBC), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and red blood cell distribution width (RDW) were compared during the first and the late second trimester. RESULTS In INTRODUCTIONNausea and vomiting are the most common complaints of pregnant women in the first trimester, affecting 70%-80% of all pregnancies (1). These mild symptoms are usually described as morning sickness (2) because nausea and vomiting typically occur in the morning and resolve during the day time. Hyperemesis gravidarum (HG) is a severe form of nausea and vomiting during pregnancy (3) that leads to weight loss, dehydration, electrolyte and acid-base imbalances, ketonuria, and nutritional deficiency (4). It affects 0.8%-3.2% of pregnant women (5, 6).

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Serum markers for prediction of spontaneous preterm delivery in preterm labour

Abstract: Combined marker could be used as a simple and sensitive parameter for identifying women at risk of spontaneous preterm delivery.

Cited by 51 publications

References 32 publications

The Delta Neutrophil Index as a predictive marker of histological chorioamnionitis in patients with preterm premature rupture of membranes: A retrospective study

The Delta Neutrophil Index as a predictive marker of histological chorioamnionitis in patients with preterm premature rupture of membranes: A retrospective study

The phenotype of spontaneous preterm birth: application of a clinical phenotyping tool

The Existence of Continuous Systemic Inflammation in Pregnant Women with Hyperemesis Gravidarum

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