Serum markers of graft-versus-host disease after bone marrow transplantation

Kayaba, Hiroyuki; Hirokawa, Makoto; Watanabe, Arata; Saitoh, Norihiro; Changhao, Cui; Yamada, Yoshiyuki; Honda, Kazuo; Kobayashi, Yoshimi; Urayama, Osamu; Chihara, Junichi

doi:10.1067/mai.2000.106060

Cited by 42 publications

(33 citation statements)

References 10 publications

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“…Release of proinflammatory cytokines such as IL-6, IL-8 (CXCL8), TNF-␣, and IFN-␥ has been correlated positively with aGVHD. [8][9][10][11][12][13][14] Although IL-6, IL-8, TNF-␣, and IFN-␥ were studied in our cohort, they did not serve as significant markers, except for in the nonmyeloablative transplantation group, where IL-8 (CXCL8) levels were significantly elevated in the aGVHD group. This could be attributed to different treatment regimens used by different transplantation centers.…”

Section: Discussionmentioning

confidence: 99%

CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation

Piper¹,

Horlock²,

Curnow

et al. 2007

Blood

112

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Section: Discussionmentioning

confidence: 99%

CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation

Piper¹,

Horlock²,

Curnow

et al. 2007

Blood

112

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“…TNF␣ is a principal mediator of GVHD in animal models, 35 and its receptors have been identified as a biomarker in some clinical studies. 9,10 The role of TNF␣ in clinical GVHD has recently been highlighted in a phase 2 study that observed a high percentage of complete responses when a soluble inhibitor of TNF␣ was added to steroids as primary treatment for GVHD. 36 IL-8 is a potent chemoattractant that is likely to help direct migration of cellular effectors to GVHD target organs.…”

Section: Discussionmentioning

confidence: 99%

“…All 4 biomarkers (IL-2R␣, TNFR1, IL-8, and HGF) that were identified in our analysis have been associated with GVHD in previous small studies. [3][4][5][6][7][8][9][10][11][12][13][14] In this study of more than 450 patients, the 2 most discriminating proteins were cytokine receptors, presumably shed into the circulation by activated donor cells that mediate acute GVHD. 33 Soluble IL-2R␣, the single best discriminator of GVHD, is a well-established marker of T-cell activation and suppression of donor T-cell responses is the mainstay of GVHD prophylaxis.…”

Section: Discussionmentioning

confidence: 99%

A biomarker panel for acute graft-versus-host disease

Paczesny

Krijanovski

Braun

et al. 2009

Blood

341

303

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No validated biomarkers exist for acute graft-versus-host disease (GVHD). We screened plasma with antibody microarrays for 120 proteins in a discovery set of 42 patients who underwent transplantation that revealed 8 potential biomarkers for diagnostic of GVHD. We then measured by enzyme-linked immunosorbent assay (ELISA) the levels of these biomarkers in samples from 424 patients who underwent transplantation randomly divided into training (n ‫؍‬ 282) and validation (n ‫؍‬ 142) sets. Logistic regression analysis of these 8 proteins determined a composite biomarker panel of 4 proteins (interleukin-2-receptor-alpha, tumornecrosis-factor-receptor-1, interleukin-8, and hepatocyte growth factor) that optimally discriminated patients with and without GVHD. The area under the receiver operating characteristic curve distinguishing these 2 groups in the training set

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“…[10][11][12][13][14][15][16][17][18][19] However, the pathophysiology of cGVHD is much less well understood than that of aGVHD, and the current understanding of cGVHD is largely the result of murine studies. In the murine system, it has been shown that post-thymic CD4 þ T cells are important in inducing cGVHD.…”

Section: Gvhd; Hsct; Cytokinesmentioning

confidence: 99%

IL-4-producing CD8+ T cells may be an immunological hallmark of chronic GVHD

Nakamura

Amakawa

Takebayashi

et al. 2005

Bone Marrow Transplant

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Summary:Chronic graft-versus-host disease (cGVHD) occurs in approximately 60-80% of those who survive over 100 days after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, the pathophysiology of cGVHD is poorly understood. To gain more insight into the immunological mechanism of cGVHD, we examine cytokine production of peripheral blood T cells from 19 patients in the chronic phase of allo-HSCT. The percentage of IFN-c-producing CD8 þ T cells among CD8 þ T cells was significantly higher in patients with or without cGVHD than in normal control subjects (Po0.001). On the other hand, the percentage of IL-4-producing CD8 þ T cells among CD8 þ T cells was significantly higher in patients with cGVHD (mean 3.3%; range 1.3-8.2%) than in patients without cGVHD (mean 1.2%; range 0.8-1.7%) and normal control subjects (mean 1.1%; range 0.1-1.6%) (both Po0.001). By contrast, the percentage of IL-4-producing CD4 þ T cells was not different among patients with and without cGVHD and normal controls. These findings suggest that IL-4-producing CD8 þ T cells may be an immunological marker of cGVHD.

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Serum markers of graft-versus-host disease after bone marrow transplantation

Cited by 42 publications

References 10 publications

CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation

CXCL10-CXCR3 interactions play an important role in the pathogenesis of acute graft-versus-host disease in the skin following allogeneic stem-cell transplantation

A biomarker panel for acute graft-versus-host disease

IL-4-producing CD8+ T cells may be an immunological hallmark of chronic GVHD

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