Serum markers of rheumatoid arthritis in visceral leishmaniasis: Rheumatoid factor and anti-cyclic citrullinated peptide antibody

Atta, Ajax Mercês; Carvalho, Edgar M.; Jerônimo, Selma M. B.; Atta, Mustafa S.

doi:10.1016/j.jaut.2006.12.001

Cited by 40 publications

(40 citation statements)

References 20 publications

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“…Although anti-CCP positivity is more specific in rheumatoid arthritis; positive results can occur in other autoimmune diseases such as SLE, primary Sjogren's syndrome, primary biliary cirrhosis and some infectious diseases [9][10][11][12]. Recent studies have demonstrated the presence of anti-CCP antibodies by ELISA in infectious diseases such as tuberculosis, leishmaniasis, atypical mycobacteriosis, hepatitides B and C, chagas disease, mononucleosis, yersinia and lyme disease [14][15][16][17][18][19]. Based on the findings of the recent studies, it can be stated that anti-CCP antibodies may be observed in patients with infectious diseases, particularly tuberculosis.…”

Section: Discussionmentioning

confidence: 99%

The antibodies cyclic citrullinated peptides (anti-CCP) positivity could be a promising marker in brucellosis patients presented with peripheric arthritis

Gokhan

Turkeyler

Babacan

et al. 2013

Modern Rheumatology

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Section: Discussionmentioning

confidence: 99%

The antibodies cyclic citrullinated peptides (anti-CCP) positivity could be a promising marker in brucellosis patients presented with peripheric arthritis

Gokhan

Turkeyler

Babacan

et al. 2013

Modern Rheumatology

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“…The levels of total globulin can be as high as 10 g per deciliter. Circulating immune complexes, autoantibodies and rheumatoid factors are present in many patients [Carvalho et al, 1983, Pearson et al, 1986, Atta et al, 2007]. Glomerulonephritis may develop, but renal failure is rare [Dettwiler et al, 2010].…”

Section: Clinical Manifestations Of Visceral Leishmaniasismentioning

confidence: 99%

New challenges in the epidemiology and treatment of visceral leishmaniasis in periurban areas

Dupnik

Nascimento

Rodrigues-Neto

et al. 2011

Drug Development Research

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Visceral leishmaniasis [VL] represents a major public health problem in many areas of the world. This review focuses on the impact of periurbanization on the epidemiology and treatment of VL, using Brazil as an example. VL continues to be mostly a disease of poverty with impact on families. However, the disease has expanded in Latin America, with foci reported as far south as Argentina. There is an increasing overlap of Leishmania infantum chagasi and HIV infections and other immunosuppressive conditions, resulting in VL emerging as an opportunistic infection. This new setting poses new challenges for VL disease control and patient management.

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“…Indeed, the anti-HCV positivity, although it was performed using a second generation assay, may be seen as a false positive result due to hypergamma globulinemia or, more specifically, linked to the production of IgM with rheumatoid factor (RF) characteristics. In fact, it has been reported that an increase in IgM-RF production is an autoimmune characteristic of VL [7] and it is well known that the presence of RF could interfere with correct anti-HCV detection, causing significant false positive reactivity [8]. Unfortunately, we did not perform RF before treatment and now RF is negative, so our suggestion remains speculative.…”

Section: Discussionmentioning

confidence: 86%

Progressive visceral leishmaniasis misdiagnosed as cirrhosis of the liver: a case report

et al. 2009

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IntroductionVisceral leishmaniasis is a potentially life-threatening infectious disease which is caused by parasites of the genus Leishmania and characterized in most cases by the presence of fever as well as signs and symptoms similar to those found in liver cirrhosis.Case presentationIn this case report we describe the history of a 50-year-old Caucasian man incorrectly diagnosed as having hepatitis C virus-associated liver cirrhosis, with a massive weight loss of around 100 kg during the previous 2 years. However, suspecting a lymphoproliferative disorder, we were able to make a correct diagnosis of visceral leishmaniasis by bone marrow examination. After a course of therapy with Liposomal Amphotericin-B the patient recovered and now, 20 months post-treatment, he is well and has regained a good part of the lost weight.ConclusionsThis case taught us that patients with massive splenomegaly, even with a diagnosis of liver cirrhosis, should be investigated for infectious or lymphoproliferative diseases.

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Serum markers of rheumatoid arthritis in visceral leishmaniasis: Rheumatoid factor and anti-cyclic citrullinated peptide antibody

Cited by 40 publications

References 20 publications

The antibodies cyclic citrullinated peptides (anti-CCP) positivity could be a promising marker in brucellosis patients presented with peripheric arthritis

The antibodies cyclic citrullinated peptides (anti-CCP) positivity could be a promising marker in brucellosis patients presented with peripheric arthritis

New challenges in the epidemiology and treatment of visceral leishmaniasis in periurban areas

Progressive visceral leishmaniasis misdiagnosed as cirrhosis of the liver: a case report

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