Serum metabolomics strategy for investigating the hepatotoxicity induced by different exposure times and doses of <i>Gynura segetum</i> (Lour.) Merr. in rats based on GC-MS

Liu, Ying; Tian, Yao; Wang, Qixue; Gu, Xinyi; Chen, Long; Jia, Yiqun; Cao, Shan; Zhang, Ting; Zhou, Mingmei; Gou, Xiaojun

doi:10.1039/d2ra07269f

RSC Adv.

2023

DOI: 10.1039/d2ra07269f

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Serum metabolomics strategy for investigating the hepatotoxicity induced by different exposure times and doses of Gynura segetum (Lour.) Merr. in rats based on GC-MS

Ying Liu

Yao Tian

Qixue Wang

et al.

Abstract: Gynura segetum (Lour.) Merr. (GS), has been widely used in Chinese folk medicine and can promote circulation, relieve pain and remove stasis.

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Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis

Liu,

Huang,

Kong

et al. 2025

Ecotoxicology and Environmental Safety

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Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis

Liu,

Huang,

Kong

et al. 2025

Ecotoxicology and Environmental Safety

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Serum metabolomics strategy for investigating the hepatotoxicity induced by different exposure times and doses of Gynura segetum (Lour.) Merr. in rats based on GC-MS

Abstract: Gynura segetum (Lour.) Merr. (GS), has been widely used in Chinese folk medicine and can promote circulation, relieve pain and remove stasis.

Cited by 1 publication

References 63 publications

Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis

Podophyllotoxin mediates hepatic toxicity via the C5a/C5aR/ROS/NLRP3 and cGMP/PKG/mTOR axis in rats based on toxicological evidence chain (TEC) concept by phosphoproteomic analysis

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