Serum microRNA-33 levels in pre-diabetic and diabetic patients

Shahouzehi, Beydolah; Eghbalian, Mostafa; Fallah, Hossein; Aminizadeh, Soheil; Masoumi‐Ardakani, Yaser

doi:10.1007/s11033-021-06425-7

Cited by 6 publications

(5 citation statements)

References 24 publications

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“…In recent years, an increasing number of miRNA research reports have been published, and miRNAs have become the focus of attention as both biomarkers and therapeutics. miRNAs can be found stably in serum and other bodily fluids and have been used as biomarkers in numerous diseases due to their endogenous nature, stability, and noninvasive biopsies, such as diabetes, diabetic nephropathy, 12 Journal of Diabetes Research DR, ophthalmic diseases, cardiovascular diseases, and various cancers [230][231][232][233][234][235][236]. However, it should be noted that miRNAs still have many limitations as a biomarker of DR, such as lack of specificity, sample source limitations, and other methodological limitations.…”

Section: Summary and Discussionmentioning

confidence: 99%

Advances in Research Related to MicroRNA for Diabetic Retinopathy

Luo,

2024

Journal of Diabetes Research

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Diabetic retinopathy (DR) is a severe microvascular complication of diabetes and is one of the primary causes of blindness in the working-age population in Europe and the United States. At present, no cure is available for DR, but early detection and timely intervention can prevent the rapid progression of the disease. Several treatments for DR are known, primarily ophthalmic treatment based on glycemia, blood pressure, and lipid control, which includes laser photocoagulation, glucocorticoids, vitrectomy, and antivascular endothelial growth factor (anti-VEGF) medications. Despite the clinical efficacy of the aforementioned therapies, none of them can entirely shorten the clinical course of DR or reverse retinopathy. MicroRNAs (miRNAs) are vital regulators of gene expression and participate in cell growth, differentiation, development, and apoptosis. MicroRNAs have been shown to play a significant role in DR, particularly in the molecular mechanisms of inflammation, oxidative stress, and neurodegeneration. The aim of this review is to systematically summarize the signaling pathways and molecular mechanisms of miRNAs involved in the occurrence and development of DR, mainly from the pathogenesis of oxidative stress, inflammation, and neovascularization. Meanwhile, this article also discusses the research progress and application of miRNA-specific therapies for DR.

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Section: Summary and Discussionmentioning

confidence: 99%

Advances in Research Related to MicroRNA for Diabetic Retinopathy

Luo,

2024

Journal of Diabetes Research

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“…Further, correlation analysis of this study suggested that among the three genes, CTSB expression was the most significantly correlated with HOMA-IR, and it was considerably down-regulated in the presence of high HOMA-IR expression. HOMA-IR expression is found to be high in diabetic subjects . In addition, HOMA-IR has been reported to aid in the improvement for identifying populations at a high risk of T2DM .…”

Section: Discussionmentioning

confidence: 99%

“…HOMA-IR expression is found to be high in diabetic subjects. 32 In addition, HOMA-IR has been reported to aid in the improvement for identifying populations at a high risk of T2DM. 33 HOMA-IR is the commonly used IR index for IR estimation from fasting glucose and insulin serum concentrations.…”

Section: ■ Discussionmentioning

confidence: 99%

Altered Cathepsin B Expression as a Diagnostic Marker of Skeletal Muscle Insulin Resistance in Type 2 Diabetes

Liu

2023

ACS Biomater. Sci. Eng.

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Insulin resistance (IR) of skeletal muscle is critical for type 2 diabetes mellitus (T2DM). Herein, we tried to identify genes critical for the IR of skeletal muscle in T2DM based on the Gene Expression Omnibus (GEO) database and in vitro cell experiments. Data sets related to skeletal muscle samples of T2DM patients were downloaded from the GEO database, and clinical information on T2DM patients in the GSE18732 data set was extracted, followed by determination of the module most related to T2DM. Then, the key genes were found after intersection analysis, followed by the analysis of the diagnostic markers of IR of skeletal muscle in T2DM. Subsequently, the mechanistic role of the key gene was illustrated by in vitro experiments in palmitate-stimulated human skeletal muscle cells (SkMCs). The black module was most associated with T2DM. Following intersection analysis with differential genes, eight key genes were obtained, including CTSB, ESR2, OAT, MSTN, PVALB, MAPK6, PHKB, and ATP2B2. Among them, CTSB had the highest diagnostic value, and its expression adversely correlated to the homeostasis assessment model for IR. Furthermore, in vitro experiments indicated that overexpression of CTSB inhibited the protein degradation of IRS-1 and GLUT4, thus attenuating the IR in palmitate-induced human SkMCs. The current study demonstrated that CTSB could act as a diagnostic marker of skeletal muscle IR in T2DM, and its overexpression inhibited palmitate-induced IR in human skeletal muscle cells.

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“…Conversely, a clinical project revealed that miR-33 levels in serum are increased in prediabetic subjects, but not in control or diabetic individuals, and miR-33 levels were negatively correlated with the homeostatic model assessment for insulin resistance (HOMA-IR). From these observations, the authors suggested miR-33 as a promising biomarker for prediabetes [ 18 ]. Further research in insulin-sensitive and insulin-resistant subjects showed that plasma miR-33a and miR-33b levels were influenced by the age of the individuals and by visceral adiposity [ 85 ].…”

Section: Mir-33 Impairments In Insulin Resistance and Diabetesmentioning

confidence: 99%

“…Other miRNAs, such as miR-15, miR-16, miR-142, miR-155, and miR-206, play a pivotal role in the development of different types of cancer [ 5 , 6 , 7 , 8 , 9 ], and several miRNAs, including miR-22, miR-372, and miR-122 [ 10 , 11 , 12 ], are important for the maintenance of glucose homeostasis and appropriate cholesterol levels [ 13 ]. In particular, the miR-33 family is crucial in the regulation of lipid metabolism and inflammation [ 14 , 15 , 16 ], and it has therefore become an important target for the treatment of obesity and dyslipidaemia [ 17 ], diabetes [ 18 ], and atherosclerosis [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of miR-33 Deficiency on Metabolic and Cardiovascular Diseases: Implications for Therapeutic Intervention

Ortega

Liu

Persaud

2023

IJMS

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MicroRNAs (miRNAs) are small noncoding RNAs that post-transcriptionally inhibit gene expression. These small molecules are involved in several biological conditions such as inflammation, cell growth and proliferation, and regulation of energy metabolism. In the context of metabolic and cardiovascular diseases, miR-33 is of particular interest as it has been implicated in the regulation of lipid and glucose metabolism. This miRNA is located in introns harboured in the genes encoding sterol regulatory element-binding protein (SREBP)-1 and SREBP-2, which are key transcription factors involved in lipid biosynthesis and cholesterol efflux. This review outlines the role of miR-33 in a range of metabolic and cardiovascular pathologies, such as dyslipidaemia, nonalcoholic fatty liver disease (NAFLD), obesity, diabetes, atherosclerosis, and abdominal aortic aneurysm (AAA), and it provides discussion about the effectiveness of miR-33 deficiency as a possible therapeutic strategy to prevent the development of these diseases.

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Serum microRNA-33 levels in pre-diabetic and diabetic patients

Cited by 6 publications

References 24 publications

Advances in Research Related to MicroRNA for Diabetic Retinopathy

Advances in Research Related to MicroRNA for Diabetic Retinopathy

Altered Cathepsin B Expression as a Diagnostic Marker of Skeletal Muscle Insulin Resistance in Type 2 Diabetes

Effects of miR-33 Deficiency on Metabolic and Cardiovascular Diseases: Implications for Therapeutic Intervention

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