Serum MMP-3 in rheumatoid arthritis: correlation with systemic inflammation but not with erosive status.

Abstract

Serum MMP-3 is not an independent marker of joint damage, but is correlated with systemic inflammation. Its precise role in joint damage in RA remains to be elucidated.

Biomarkers predict radiographic progression in early rheumatoid arthritis and perform well compared with traditional markers

“…This lends indirect support to the notion that destruction and inflammation are distinct processes that do not necessarily occur together but may, as has been previously suggested, become "uncoupled" (48). Some authors suggest that levels of MMP-3 simply respond as markers of inflammation, rather than as markers of joint destruction (49)(50)(51). However, the results of our multivariate modeling indicate that MMP-3 levels are intimately related to destructive processes that result in radiographic progression.…”

Influence of variations across the MMP-1 and -3 genes on the serum levels of MMP-1 and -3 and disease activity in rheumatoid arthritis

“…Association of the MMP-1-MMP-3 loci with disease activity Previous studies have shown significant correlations of MMP-1, and particularly MMP-3 serum levels with levels of inflammation in RA. 7,[9][10][11][13][14][15] In this study, we found significant correlations of MMP-1 and MMP-3 with the level of disease activity (DAS28 at baseline Figure 2 Relationship between MMP genotypes and circulating levels of MMPs. Panels (a-d) show serum levels of MMP-1 in patients with different genotypes of rs1799750, rs495366, rs679620 and rs3025058, respectively.…”

“…Elevated levels of MMP-1 and -3 have been observed in patients with RA in both serum and synovial fluid, and are strongly associated with inflammation and joint destruction. [6][7][8][9][10][11][12][13][14][15][16][17][18][19] The genes for MMP-1 and -3 are both located on the long arm of chromosome 11, in a cluster together with seven other MMP members including MMP-7, -8, -10, -12 and -13. In recent years, functionally relevant and phenotype associated polymorphisms have been detected across the region of both genes.…”

“…Serum levels of MMP-1, and MMP-3 in particular, have been considered to be a useful markers of inflammation in RA, 7,[9][10][11][13][14][15] and have been shown to be predictive of joint destruction in early RA as well as reflecting ongoing joint damage in established RA. [11][12][13]15 In this study, we provide the most detailed analysis to date of the genotypic and haplotypic relationships of the MMP-1 and -3 genes with circulating levels of these MMPs in RA, and have investigated whether polymorphisms at these loci are associated with the level of disease activity over time.…”

Proteolysis of AA Amyloid Fibril Proteins by Matrix Metalloproteinases-1, -2, and -3

“…[23][24][25] MMP-3 is not an independent marker of joint disease in rheumatoid arthritis, but is correlated with systemic inflammation. 26 Inflammatory cytokines (such as interleukin-1, interleukin-6, tumor necrosis factor-␣) are potent inducers of some MMPs including MMP-1, -3, and -9, and they may increase transcription by as much as 100-fold. [27][28][29] The production and secretion of MMP-2 and -3 can be stimulated by the acute-phase protein SAA.…”