Serum molybdenum concentration in healthy Japanese adults determined by inductively coupled plasma-mass spectrometry

Investigating the host and bacterial factors in cystic fibrosis that promote persistence of infection in the lung

“…In humans, Mo co-factored proteins are incorporated into the flavoenzymes, which catalyse critical detoxification pathways (311). Increased serum Mo concentrations have been reported in patients with liver disease, a finding not inconsistent with our sputum findings, although we did not assess Mo levels in serum to confirm a corresponding increase in systemic levels (312).…”

Immunological and Biochemical Markers in Oral Carcinogenesis: The Public Health Perspective

“…Resultantly, further research on the role of this element in the etiopathogenesis of aerodigestive tract and oral carcinomas, has been recommended [32]. Other areas of further research have been identified including the following [33]:

▪ Modifiable common risk factors to oral health and chronic disease, particularly the role of diet, nutrition and tobacco.

▪ Oral health-general health interrelationships.

▪ Psychosocial implications of oral health/illness and quality of life

▪ Inequity in oral health and disease.

▪ Diagnostics and cost-effective intervention strategies in relation to certain conditions such as noma and craniofacial birth defects.

▪ Population studies of oral mucosal lesions, including epidemiological surveys of HIV/AIDS related oral disease in developing countries.

▪ Health systems research on reorientation of oral health services towards prevention and health promotion.

▪ Time-series data for oral health surveillance in developing countries.

…”

Molybdenum in Biological Samples and Clinical Significance of Serum Molybdenum

“…Liver Dysfunction In a Belgian study, serum Mo concentration was significantly increased in subjects with various types of liver disease and significant correlations between serum Mo and activities of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were observed [23]. Significant correlations between serum Mo and the activities of AST and ALT were also found in the Japanese study [11]. Since Mo accumulates in the liver at a level of more than 300 mg/kg [32], high serum Mo in subjects with liver dysfunction may be derived from a liver leakage.…”

“…Among these, ETA-AAS and ICP-MS have the lion's share to determine Mo in biological samples. In the following sections the applicability of ICP-MS methods to Mo quantification as developed in the author's laboratory is described [9][10][11][12].…”

“…Table 14.5 shows the Mo concentration in healthy human blood measured in various countries. Serum Mo concentration in Japanese subjects showed a logarithmic normal distribution [11], while the variation coefficient of serum Mo in Belgian subjects was comparatively low [23]. The average values of plasma or serum Mo concentration were similar among Japanese, Belgian, and American [24] subjects although several Japanese subjects showed slightly higher values.…”