Serum monoclonal immunoglobulin bands in undifferentiated lymphomas of Burkitt and non-Burkitt types

Magrath, I; Benjamin, D; Papadopoulos, N

doi:10.1182/blood.v61.4.726.bloodjournal614726

Cited by 2 publications

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“…Ko and Pruzanski 12 detected an IgM protein in 33 of 62 patients with lymphoma who had an M compo nent in their serum. Magrath and associates 20 found an IgM protein in the serum specimens of 12 of 21 patients with undifferentiated lymphoma of Burkitt or non-Burkitt type with use of agarose gel electrophoresis and immunofixation.…”

Section: Discussionmentioning

confidence: 99%

The Spectrum of IgM Monoclonal Gammopathy in 430 Cases

Kyle¹,

Garton²

1987

Mayo Clinic Proceedings

206

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IgM monoclonal gammopathy consists of a broad spectrum of diseases, ranging from apparently benign to malignant conditions. In a long-term follow-up study of 430 patients in whom a monoclonal IgM serum protein had been identified, 242 (56%) had monoclonal gammopathy of undetermined significance, 71 (17%) had Waldenström's macroglobulinemia, 28 (7%) had lymphoma, 21 (5%) had chronic lymphocytic leukemia, 6 (1%) had primary amyloidosis, and 62 (14%) had other malignant lymphoproliferative diseases. More than two-thirds of the patients died, and the most common cause of death was a lymphoid malignant process. Almost a fifth of the patients with an apparently benign monoclonal gammopathy subsequently had a lymphoid malignant lesion (in one patient, more than 20 years after the detection of the serum M protein). The median duration of time from the recognition of the M protein until the development of a malignant lymphoid disease ranged from 4 to 9 years. An increased number of lymphocytes or plasma cells on bone marrow examination was not a reliable indicator of the likelihood of such an outcome. Thus, follow-up of these patients should be conducted indefinitely.

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Section: Discussionmentioning

confidence: 99%

The Spectrum of IgM Monoclonal Gammopathy in 430 Cases

Kyle¹,

Garton²

1987

Mayo Clinic Proceedings

206

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“…It should be noted that the latter series was published before the definition of stringent diagnostic criteria in the 1990s, and CLL could only be regarded as a probable diagnosis. In a small series of undifferentiated lymphomas of non‐African Burkitt's and non‐Burkitt's type, monoclonal bands were detected in 42% (Magrath, Benjamin & Papadopoulos, 1983).…”

Section: Discussionmentioning

confidence: 99%

Frequent discordance of the light-chain isotypes expressed by serum monoclonal components and leukaemic B-cells

Brohée

Cauchie

Delval

et al. 2002

Clinical &Amp; Laboratory Haematology

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In B-cell malignancies, it is generally held that the monoclonal components (MC) are produced by the malignant clones. Genetic relatedness implies the concordant expression of light-chain (LC) isotypes in the MC and at the surface of the malignant lymphocytes. We reviewed a series of 91 B-cell leukaemias, immunophenotyped by flow cytometry in our laboratory. A serum MC had been sought in 75 of these patients, and had been found in 23 (31%). Biclonal serum components were detected in three cases. LC concordance could not be assessed in three cases of surface LC-null lymphocytes. Of the 23 MC studied in 20 patients, light-chains were discordant in 39%, mostly due to kappa MC in lambda leukaemias. The origin of LC discordance remains speculative. It could be due to the emergence of subclones with the same primal VDJ gene rearrangement or, alternatively, to the development of new B-cell clones escaping immune surveillance from deregulated T-cells.

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Serum monoclonal immunoglobulin bands in undifferentiated lymphomas of Burkitt and non-Burkitt types

Cited by 2 publications

References 0 publications

The Spectrum of IgM Monoclonal Gammopathy in 430 Cases

The Spectrum of IgM Monoclonal Gammopathy in 430 Cases

Frequent discordance of the light-chain isotypes expressed by serum monoclonal components and leukaemic B-cells

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