Serum monomeric α2-macroglobulin as a clinical biomarker in diabetes

Takada, Tesshu; Kodera, Yasuhiro; Matsubara, Madoka; Kawashima, Yusuke; Maeda, Tadakazu; Fujita, Yoshikuni; Shichiri, Masayoshi

doi:10.1016/j.atherosclerosis.2013.02.035

Cited by 23 publications

(21 citation statements)

References 28 publications

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“…showed that the bone-marrow-derived CD133(+) endothelial progenitor cells and CD14(+) monocytes may contribute to vasculogenesis in PDR. [47] Serum monomeric α2-macroglobulin was highly expressed in many diabetic patients as compared to respective control in a study done by Takada et al .,[48] Shiba et al . demonstrated that vitreous fluid sLR11 level may be a novel risk factor for the early development of PDR before the increase in circulating levels in diabetic patients.…”

Section: Circulating Biomarkers In Diabetic Retinopathymentioning

confidence: 99%

Circulating biomarkers in glaucoma, age-related macular degeneration, and diabetic retinopathy

Nath

Halder

Velpandian

2017

Indian J Ophthalmol

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Biomarkers to predict the altering physiological conditions over the period leading toward the ocular disorders are of major importance in therapeutics. Isolation and validation of the biomarkers specific to ocular diseases are a challenging task. Glaucoma is a neurodegenerative disease of the eye where the correlation of biomarkers in circulating fluid may be made specific for the eye. However, conditions such as wet age-related macular degeneration (AMD) and proliferative diabetic retinopathy (DR), circulating biomarkers might be having some degree of overlap with other conditions like cancer where a common factor such as angiogenesis is involved. Diabetes, a systemic disorder affecting the target organs such as eye, kidney, heart, and nervous system can be predicted using common circulating biomarkers. However, these markers need to be validated along with various stages of disease progression to enable the possibility of targeted pharmacological interventions apart from good glycemic control alone. This review compiles the attempts made to correlate such circulating biomarkers in the ocular conditions such as glaucoma, AMD, and DR in the search for a surrogate marker for diagnostic and prognostic value. To make biomarkers for the common convenience, genetic markers are excluded from this review.

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Section: Circulating Biomarkers In Diabetic Retinopathymentioning

confidence: 99%

Circulating biomarkers in glaucoma, age-related macular degeneration, and diabetic retinopathy

Nath

Halder

Velpandian

2017

Indian J Ophthalmol

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“…Since Smith and colleagues have already reported that haptoglobin levels were not significantly different between 10 BR and 20 WR kept in captivity [8], it may not play an important role in the BR’s α 2 -globulin increase in the present study. α 2 -macroglobulin inhibits numerous endogenous proteases and acts as a transport protein for cytokines and growth factors [57]. Increased α 2 -macroglobulin is favored by inflammatory states, such as diabetes mellitus in humans [57].…”

Section: Discussionmentioning

confidence: 99%

“…α 2 -macroglobulin inhibits numerous endogenous proteases and acts as a transport protein for cytokines and growth factors [57]. Increased α 2 -macroglobulin is favored by inflammatory states, such as diabetes mellitus in humans [57]. Ceruloplasmin levels increase with inflammation in humans [58].…”

Section: Discussionmentioning

confidence: 99%

Inflammatory and oxidative status in European captive black rhinoceroses: a link with Iron Overload Disorder?

Pouillevet

Soetart

Boucher

et al. 2020

Preprint

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17Iron Overload Disorder (IOD) is a syndrome developed by captive browsing 18 rhinoceroses like black rhinoceroses (Diceros bicornis) in which hemosiderosis settles in vital 19 organs while free iron accumulates in the body, potentially predisposing to various secondary 20 diseases. Captive grazing species like white rhinoceroses (Ceratotherium simum) do not seem 21 to be affected. The pro-oxidant and pro-inflammatory properties of iron, associated with the 22 poor antioxidant capacities of black rhinoceroses, could enhance high levels of inflammation 23 and oxidative stress leading to rapid ageing and promoting diseases. In this prospective study, 24 15 black (BR) and 29 white rhinoceroses (WR) originating from 22 European zoos were blood-25 sampled and compared for their iron status (serum iron), liver/muscle biochemical parameters 26 (AST, GGT, cholesterol), inflammatory status (total proteins, protein electrophoresis) and 27 oxidative stress markers (SOD, GPX, dROMs). Results showed higher serum iron and liver 28 enzyme levels in black rhinoceroses (P<0.01), as well as higher GPX (P<0.05) and dROM 29 (P<0.01) levels. The albumin/globulin ratio was lower in black rhinoceroses (P<0.05) due to 30 higher  2 -globulin levels (P<0.001). The present study suggests a higher inflammatory and 31 oxidative profile in captive BR than in WR, possibly in relation to iron status. This could be 32 either a consequence or a cause of iron accumulation, potentially explaining rapid ageing and 33 various diseases. Further investigations are needed to assess the prognostic value of the 34 inflammatory and oxidative markers in captive black rhinoceroses, particularly for evaluating 35 the impact of reduced-iron and antioxidant-supplemented diets. 36

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“…Важную роль в профилактике КРС 2-го типа играет оптимальное управление балансом натрия и экстрацеллюляр-ной жидкости, что достигается при низкосолевой диете и адекватном использовании диуретических препаратов [63]. Лекарственными средствами, снижающими заболеваемость и смертность, по-тенциально замедляющими прогрессирование ХСН, являются иАПФ, бета-адреноблокаторы, АРА и антагонисты альдостерона.…”

Section: ëå÷åáíàÿ òàêòèêà ïðè êðñ 2-ãî òèïàunclassified

Кардіоренальний Синдром: Діагностика Та Лікування

Melnyk¹

2021

KIDNEYS

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Кардиоренальный синдром (КРС) -это патоло-гические взаимообусловленные состояния с вовле-чением сердца и почек, развивающиеся вследствие острой или хронической дисфункции одного из ор-ганов с последующей острой или хронической дис-функцией другого органа. КРС включает различные острые и хронические расстройства, при которых первично пораженным органом может быть как сердце, так и почка.Почки, являясь органом, участвующим в важных метаболических процессах, регуляции гуморальной системы, процессах микроциркуляции, подверже-ны острым и хроническим воздействиям при раз-личных сердечно-сосудистых заболеваниях (ССЗ) и влияют на формирование и прогрессирование сер-дечно-сосудистой патологии. Почечная дисфунк-ция ассоциирована с более высокой частотой реци-дивов ишемии миокарда, инфаркта миокарда (ИМ), инсульта, серьезных геморрагических осложнений, острой сердечной недостаточности, фибрилляции предсердий и желудочков. Даже небольшое сниже-ние функции почек значительно усугубляет течение основной кардиальной патологии, одновременно УДК 616.124-616.61 DOI: 10.22141/2307УДК 616.124-616.61 DOI: 10.22141/ -1257УДК 616.124-616.61 DOI: 10.22141/ .6.1.2017 Ìåëüíèê À.À.

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Serum monomeric α2-macroglobulin as a clinical biomarker in diabetes

Cited by 23 publications

References 28 publications

Circulating biomarkers in glaucoma, age-related macular degeneration, and diabetic retinopathy

Circulating biomarkers in glaucoma, age-related macular degeneration, and diabetic retinopathy

Inflammatory and oxidative status in European captive black rhinoceroses: a link with Iron Overload Disorder?

Кардіоренальний Синдром: Діагностика Та Лікування

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