Serum myeloid‐related protein 8/14 in minimal change‐ and glomerulonephritis‐related nephrotic syndrome

Ohara, Shinichiro; Kawasaki, Yukihiko; Maeda, Ryo; Kanno, Syuto; Suzuki, Yuichi; Suyama, Kazuhide

doi:10.1111/ped.12947

Pediatrics International

2016

DOI: 10.1111/ped.12947

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Serum myeloid‐related protein 8/14 in minimal change‐ and glomerulonephritis‐related nephrotic syndrome

Shinichiro Ohara

Yukihiko Kawasaki

Ryo Maeda

et al.

Abstract: Serum MRP8/14 level may be a useful indicator for differential diagnosis between GN- and MC- related NS.

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Cited by 2 publications

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小児腎臓疾患の今と昔： IgA 腎症の発症病態からみた治療の進歩

幸彦

2021

Nihon Shoni Jinzobyo Gakkai Zasshi

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IgA nephropathy (IgAN) is more frequently found in chronic glomerulonephritis (CGN) in childhood. Recently, it is reported that the pathogenesis of IgAN may be associated with defective IgA1 forms circulating or in situ immune complexes. In the presence of the genetic backgrounds, the defective IgA1 immune complex produced by T cells and B cells activated by antigen stimulation is deposited in the glomerulus and these immune complexes induce inflammation through activation of complement, macrophages and mesangial cells, and glomerular damage progresses. The prognosis of IgA nephropathy varies from normalization of urinary findings to deterioration of proteinuria and deterioration of renal function. To control these inflammations, each useful treatment was chosen according to the severity of IgAN. For children with severe IgAN, the long-term prognosis improved by multi-drug combination therapy including steroid and immunosuppressive drugs or tonsillectomy steroid plus therapy. In the future, it is expected that a treatment method with less side effects will be established.

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小児腎臓疾患の今と昔： IgA 腎症の発症病態からみた治療の進歩

幸彦

2021

Nihon Shoni Jinzobyo Gakkai Zasshi

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Fecal Calprotectin and the Complications of IgA-mediated Vasculitis: A Cohort Study

Asna Ashari,

Alimadadi,

Sadeghi

et al. 2024

J Compr Ped

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Background: Immunoglobulin A (IgA)-mediated vasculitis, previously known as Henoch-Schönlein Purpura (HSP), is the most common vasculitis in children. It affects the skin, joints, gastrointestinal (GI) system, and kidneys. Calprotectin is a calcium-binding protein mainly found in neutrophils and macrophages, and its levels increase in settings of inflammation. Objectives: We conducted a study to investigate the role of calprotectin in prediction of HSP complications. Methods: In this cohort study, patients diagnosed with HSP by EULAR/PRINTO/PRES criteria and admitted to two referral children’s hospitals in Tehran, Iran, were enrolled. Fecal calprotectin levels were checked at the beginning of the presentation, and the patients were followed for GI and renal manifestations. Results: Out of the 100 patients who began to participate, 47 were eventually enrolled (25% girls). The age range was 2 to 18 years, with a mean of 6.5 ± 2.9 years. Hematuria was found in 21% and proteinuria in 17%. The Mann-Whitney test found an association between calprotectin and blood in stool (P = 0.03). No association was found between calprotectin and abdominal pain, sonography findings, hematuria, or proteinuria. The Pearson correlation test found a positive correlation between calprotectin level and leukocyte count (P = 0.003), neutrophil count (P = 0.002), and CRP (P = 0.03). Conclusions: Positive blood in stool was associated with fecal calprotectin levels in HSP, but hematuria and proteinuria were not. Considering the high cost of the calprotectin test, monthly follow-up with urine analysis appears to be a more logical approach. Neutrophil count and CRP were found to correlate with calprotectin levels, highlighting the nature of calprotectin as an acute inflammatory marker elevated during the acute phase of HSP disease.

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Serum myeloid‐related protein 8/14 in minimal change‐ and glomerulonephritis‐related nephrotic syndrome

Abstract: Serum MRP8/14 level may be a useful indicator for differential diagnosis between GN- and MC- related NS.

Cited by 2 publications

References 20 publications

小児腎臓疾患の今と昔： IgA 腎症の発症病態からみた治療の進歩

小児腎臓疾患の今と昔： IgA 腎症の発症病態からみた治療の進歩

Fecal Calprotectin and the Complications of IgA-mediated Vasculitis: A Cohort Study

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Serum myeloid‐related protein 8/14 in minimal change‐ and glomerulonephritis‐related nephrotic syndrome

Abstract: Serum MRP8/14 level may be a useful indicator for differential diagnosis between GN- and MC- related NS.

Cited by 2 publications

References 20 publications

小児腎臓疾患の今と昔 ： IgA 腎症の発症病態からみた治療の進歩

小児腎臓疾患の今と昔 ： IgA 腎症の発症病態からみた治療の進歩

Fecal Calprotectin and the Complications of IgA-mediated Vasculitis: A Cohort Study

Contact Info

Product

Resources

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小児腎臓疾患の今と昔： IgA 腎症の発症病態からみた治療の進歩

小児腎臓疾患の今と昔： IgA 腎症の発症病態からみた治療の進歩