Serum Myeloperoxidase, C-reactive Protein and α1-acid Glycoprotein: Insights about Cardiovascular Risk in End-stage Renal Disease

Rickli, Cristiane; Borato, Danielle Cristyane Kalva; Silva, Anderson José de Melo E; Schuinski, Adriana Fatima Menegat; Vilela, Gustavo Henrique Frigieri; Vellosa, José Carlos Rebuglio

doi:10.1055/a-0895-5138

Cited by 5 publications

(2 citation statements)

References 38 publications

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“…The presence of isolated systolic AHT, lower DBP, PP widening, and excessive nDBP dipping are important features in arterial stiffness [ 13 ]. Some studies also support that low levels of some alpha-1-globulins are associated with lower BP figures and fewer cardiovascular events whereas some alpha-2-globulins have been associated with greater arterial stiffness [ 36 , 37 , 38 ].…”

Section: Discussionmentioning

confidence: 99%

Implications of Inflammatory and Oxidative Stress Markers in the Attenuation of Nocturnal Blood Pressure Dipping

Hermida‐Ameijeiras

Vazquez-Agra

Cruces-Sande

et al. 2023

JCM

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To date, no model has jointly encompassed clinical, inflammatory, and redox markers with the risk of a non-dipper blood pressure (BP) profile. We aimed to evaluate the correlation between these features and the main twenty-four-hour ambulatory blood pressure monitoring (24-h ABPM) indices, as well as to establish a multivariate model including inflammatory, redox, and clinical markers for the prediction of a non-dipper BP profile. This was an observational study that included hypertensive patients older than 18 years. We enrolled 247 hypertensive patients (56% women) with a median age of 56 years. The results showed that higher levels of fibrinogen, tissue polypeptide-specific antigen, beta-2-microglobulin, thiobarbituric acid reactive substances, and copper/zinc ratio were associated with a higher risk of a non-dipper BP profile. Nocturnal systolic BP dipping showed a negative correlation with beta-globulin, beta-2-microglobulin, and gamma-globulin levels, whereas nocturnal diastolic BP dipping was positively correlated with alpha-2-globulin levels, and negatively correlated with gamma-globulin and copper levels. We found a correlation between nocturnal pulse pressure and beta-2-microglobulin and vitamin E levels, whereas the day-to-night pulse pressure gradient was correlated with zinc levels. Twenty-four-hour ABPM indices could exhibit singular inflammatory and redox patterns with implications that are still poorly understood. Some inflammatory and redox markers could be associated with the risk of a non-dipper BP profile.

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Section: Discussionmentioning

confidence: 99%

Implications of Inflammatory and Oxidative Stress Markers in the Attenuation of Nocturnal Blood Pressure Dipping

Hermida‐Ameijeiras

Vazquez-Agra

Cruces-Sande

et al. 2023

JCM

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“…É, portanto, um mediador de resposta inflamatória comparticipação importante em doenças cardiovasculares (ARATANI, 2017;MALECKI et al, 2020). Rickli et al (2020) observaram que os níveis séricos da mieloperoxidase encontraram-se alterados em indivíduos com doença renal crônica que realizam hemodiálise.…”

Section: Atuação De Biomoléculas Com Potencial De Biomarcadores Do Estresse Oxidativounclassified

Estresse Oxidativo: Uma Introdução Ao Estado Da Arte / Oxidative Stress: An Introduction to the State of Art

Vellosa¹,

Biavatti²,

Françóia³

et al. 2021

BJD

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Neutrophils—biology and diversity

Maier-Begandt,

Alonso-Gonzalez,

Klotz

et al. 2023

Nephrology Dialysis Transplantation

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Neutrophils, the most abundant white blood cells in the human circulation, play crucial roles in various diseases, including kidney disease. Traditionally viewed as short-lived pro-inflammatory phagocytes that release reactive oxygen species, cytokines and neutrophil extracellular traps, recent studies have revealed their complexity and heterogeneity, thereby challenging this perception. Neutrophils are now recognized as transcriptionally active cells capable of proliferation and reverse migration, displaying phenotypic and functional heterogeneity. They respond to a wide range of signals and deploy various cargo to influence the activity of other cells in the circulation and in tissues. They can regulate the behavior of multiple immune cell types, exhibit innate immune memory, and contribute to both acute and chronic inflammatory responses while also promoting inflammation resolution in a context-dependent manner. Here, we explore the origin and heterogeneity of neutrophils, their functional diversity, and the cues that regulate their effector functions. We also examine their emerging role in infectious and non-infectious diseases with a particular emphasis on kidney disease. Understanding the complex behavior of neutrophils during tissue injury and inflammation may provide novel insights, thereby paving the way for potential therapeutic strategies to manage acute and chronic conditions. By deciphering their multifaceted role, targeted interventions can be developed to address the intricacies of neutrophil-mediated immune responses and improve disease outcomes.

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Serum Myeloperoxidase, C-reactive Protein and α1-acid Glycoprotein: Insights about Cardiovascular Risk in End-stage Renal Disease

Cited by 5 publications

References 38 publications

Implications of Inflammatory and Oxidative Stress Markers in the Attenuation of Nocturnal Blood Pressure Dipping

Implications of Inflammatory and Oxidative Stress Markers in the Attenuation of Nocturnal Blood Pressure Dipping

Estresse Oxidativo: Uma Introdução Ao Estado Da Arte / Oxidative Stress: An Introduction to the State of Art

Neutrophils—biology and diversity

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