Serum myeloperoxidase/paraoxonase 1 ratio as potential indicator of dysfunctional high-density lipoprotein and risk stratification in coronary artery disease

Haraguchi, Yoko; Toh, Ryuji; Hasokawa, Minoru; Nakajima, Hideto; Honjo, Tomoyuki; Otsui, Kazunori; Mori, Kensaku; Miyamoto-Sasaki, Maki; Shinohara, Masakazu; Nishimura, Kunihiro; Ishida, Tatsuro; Hirata, Ken‐ichi

doi:10.1016/j.atherosclerosis.2014.03.009

Cited by 70 publications

(56 citation statements)

References 29 publications

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“…Therefore, we assessed PON1 arylesterase activity in place of mass or paraoxonase activity in the present study. Previous studies have shown that PON1 enzyme activities are significantly decreased in patients with diabetes or cardiovascular diseases [29,30]. Also, low plasma PON1 activity has been associated with the prevalence of cardiovascular diseases [30e32].…”

Section: Discussionmentioning

confidence: 99%

Administration of high dose eicosapentaenoic acid enhances anti-inflammatory properties of high-density lipoprotein in Japanese patients with dyslipidemia

et al. 2014

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Section: Discussionmentioning

confidence: 99%

Administration of high dose eicosapentaenoic acid enhances anti-inflammatory properties of high-density lipoprotein in Japanese patients with dyslipidemia

et al. 2014

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“…Our previous study on a similar patient population also highlighted the importance of this reciprocal inhibition [29] . Furthermore, a recent study showed that serum MPO/PON1 ratio may be a potential indicator of dysfunctional highdensity lipoprotein and risk stratification in coronary artery disease [30] . Therefore, MPO/PON1 ratio was also calculated and we found significantly higher MPO/ PON1 ratio in our dyslipidemic patients compared to controls indicating an increased risk for cardiovascular complications.…”

Section: Discussionmentioning

confidence: 99%

HDL subfraction distribution and HDL function in untreated dyslipidemic patients

Harangi¹,

Szentpéteri²,

Nádró³

et al. 2017

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Aim:The protective role of high-density lipoprotein (HDL) against atherosclerosis is well known. However, both structural and functional changes of the HDL particles may affect its protective efficacy. Increased levels of HDL-associated myeloperoxidase (MPO) and decreased HDL-linked paraoxonase-1 (PON1) activity have been reported in dyslipidemic patients. Some changes in HDL subfraction distributions were also studied previously, but data on structural and functional changes in dyslipidemia are not complete. Therefore, the authors aimed to evaluate these qualitative and quantitative markers of HDL in dyslipidemic patients and healthy control subjects. Methods: Anthropometric parameters, serum levels of lipoproteins and MPO, as well as PON1 activities were investigated in 81 untreated dyslipidemic patients and in 32 healthy gender-matched controls. Additionally, HDL subfractions were detected by an electrophoretic method on polyacrylamide gel (Lipoprint). Results: Significantly higher glucose, hemoglobin A1c, total cholesterol, low-density lipoprotein-cholesterol, triglyceride, lipoprotein(a), apolipoprotein B, C-reactive protein, and MPO levels were found in patients compared to the healthy subjects. There were no significant differences in PON1 paraoxonase and arylesterase activities between the two study groups, but MPO/PON1 ratio was significantly higher in patients. There was a shift towards the smaller HDL subfractions, but only the intermediate HDL ratio was significantly lower in patients compared to controls. Conclusion:The results highlight the importance of HDL-associated pro-and antioxidant enzymes suggesting the possible clinical benefit of MPO/PON1 calculation and confirm that quantification of HDL-C level alone provides limited data regarding HDL's cardioprotective effect. Calculation of MPO/PON1 ratio may be a useful cardiovascular marker in dyslipidemia. Key words:High-density lipoprotein, subfraction, paraoxonase, myeloperoxidase, dyslipidemia ABSTRACTArticle history:

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“…Moreover, it has been found that in CVD patients with normal cholesterol levels the interconnection of HDL-C with PON1 is shifted to an interconnection of HDL-C with MPO, a phenomenon that was not observed in the healthy control group [90]. Furthermore, patients with acute coronary symptoms are characterised by a higher MPO/PON1 ratio vs. the healthy control patients, and this ratio is inversely correlated with the HDL-C particle size [27,69]. The MPO has the potential to oxidise apoA-I, which is the main apoprotein of HDL-C that is responsible for RCT and in this way generate dysfunctional HDL-C [34,75].…”

Section: Paraoxonase 1 Myeloperoxidase and Hdl-cmentioning

confidence: 93%

The contribution of paraoxonase 1 and myeloperoxidase to HDL-cholesterol functionality

Malara

Kęska

Lutosławska

2016

Biomedical Human Kinetics

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SummaryThe purpose of this study was to analyse the scientific evidence concerning the effects of two enzymes -paraoxonase 1 and myeloperoxidase -on the functions of HDL-cholesterol. It is well documented that disturbed circulating lipoproteins (a high total and high LDL-cholesterol, and low HDL-cholesterol) bring about atherosclerosis and an increased risk of cardiovascular disease (CVD) which is recognised as the main cause of death all around the world. In consequence, numerous studies have focused on procedures which will improve the plasma lipoproteins profile by decreasing the total cholesterol and the LDL-cholesterol (LDL-C) and increasing the HDL-cholesterol (HDL-C). However, the anti-atherogenic role of HDL-C has been challenged in studies showing that genetically elevated HDL-cholesterol does not offer protection against CVD. Moreover, it has been found that raising the circulating HDL-cholesterol fails to reduce atherosclerosis. The doubts concerning the protective role of HDL-C have been supported by in vitro studies which indicate that the HDL-C from patients with atherosclerosis does not have a protective action, but does stimulate inflammation and free radical synthesis. The above data suggests that HDL-C, commonly recognised as protective against atherosclerosis, in some circumstances becomes pro-atherogenic, and is thus dysfunctional. Our review focuses on two enzymes -paraoxonase 1 (PON1) and myeloperoxidase (MPO) -which markedly affect the properties of HDL-C and contribute to its anti -or pro-atherogenic activity. Moreover, the effects of the diet and physical activity on PON1 and MPO are summarised with respect to the HDL-C functionality.

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Serum myeloperoxidase/paraoxonase 1 ratio as potential indicator of dysfunctional high-density lipoprotein and risk stratification in coronary artery disease

Abstract: MPO/PON1 ratio could be a useful marker for secondary prevention of coronary artery disease through modulation of HDL function.

Cited by 70 publications

References 29 publications

Administration of high dose eicosapentaenoic acid enhances anti-inflammatory properties of high-density lipoprotein in Japanese patients with dyslipidemia

Administration of high dose eicosapentaenoic acid enhances anti-inflammatory properties of high-density lipoprotein in Japanese patients with dyslipidemia

HDL subfraction distribution and HDL function in untreated dyslipidemic patients

The contribution of paraoxonase 1 and myeloperoxidase to HDL-cholesterol functionality

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