Serum myoglobin in acute myocardial infarction: A clinical study and review of the literature

Myoglobin as a prognostic indicator for outcome in dogs with gastric dilatation‐volvulus

“…32,33 Mb is located in skeletal and cardiac muscle and represents 2% of the cytoplasmic protein in these cells. 31,34,35 It is not only present in striated muscle, but can also be found in human smooth muscle tissue. With immunohistologic techniques, Mb can be detected in very low concentrations in the colon, small intestine, uterus, and bladder as well as in arteries and veins.…”

“…36 Cell injury caused by inadequate tissue perfusion or trauma may lead to the release of Mb in the circulation. 35 Blood Mb levels can be elevated in several conditions with muscle cell injury such as acute myocardial infarction, acute vascular occlusion, rhabdomyolysis, myopathies, after vigorous exercise, ventricular tachycardia, shock, and seizures. 31,35 Because Mb is eliminated through the kidney, serum Mb levels can also be elevated in renal failure.…”

“…35 Blood Mb levels can be elevated in several conditions with muscle cell injury such as acute myocardial infarction, acute vascular occlusion, rhabdomyolysis, myopathies, after vigorous exercise, ventricular tachycardia, shock, and seizures. 31,35 Because Mb is eliminated through the kidney, serum Mb levels can also be elevated in renal failure. 31,33,35,37 In other investigations, the elimination of Mb was not affected by the glomerular filtration rate and elimination of Mb was not influenced by renal function, suggesting a major role for extrarenal removal.…”

“…31,35 Because Mb is eliminated through the kidney, serum Mb levels can also be elevated in renal failure. 31,33,35,37 In other investigations, the elimination of Mb was not affected by the glomerular filtration rate and elimination of Mb was not influenced by renal function, suggesting a major role for extrarenal removal. 38,39 A commercially available point-of-care system has been used in humans for quantification of Mb, cTnT and D-dimers.…”

Cardioprotection of cariporide evaluated by plasma myoglobin and troponin I in myocardial infarction in pigs

“…Myoglobin is an oxygen-binding haeme protein, present in the cardiac and skeletal muscles. It constitutes about 2% of the total muscle protein and is located in the cytoplasm [21]. Cell injury during acute myocardial infarction releases myoglobin into the blood circulation.…”