Serum N-Terminal Pro-B-Type Natriuretic Peptide (NTproBNP) Levels Are Elevated During the Acute Phase of Acute Encephalopathy-Associated Virus Infection

Abstract

Acute virus-associated encephalopathy induces seizures. Serum N-terminal pro-B-type natriuretic peptide (NTproBNP) levels are elevated following febrile and afebrile seizures. However, the role of NTproBNP in acute virus-associated encephalopathy pathology is unknown. We enrolled 10 patients with acute virus-associated encephalopathy and convulsions (E group: 7 boys, 3 girls; median age, 3.10 ± 1.92 years) and 130 patients with febrile seizure (FS group: 80 boys, 50 girls; median age, 3.23 ± 2.44 years). The E group had significantly higher NTproBNP levels (345 ± 141 pg/mL) compared with the FS group (166 ± 228 pg/mL) (P < .0005). Furthermore, subjects with prolonged seizure within the E group had significantly higher NTproBNP levels (303 ± 107 pg/mL) compared with subjects with prolonged seizure within the FS group (134 ± 100 pg/mL) (P < .005). Our findings suggest that serum NTproBNP levels are increased during the acute phase of acute virus-associated encephalopathy associated with convulsion.

Predictive and Prognostic Factors of Viral Encephalitis in Pediatric Patients

“…예후인자와 관련하여 많은 연구들이 보고되었으며 불량한 예후 인자 로서 낮은 연령, 발작, 국소 신경학적 징후들, 낮은 글라스고우혼수척 도(Glasgow coma scale)점수 그리고 비정상적인 방사선학적 소견 등이 보고되었다 11,12) . 또한 발작을 동반한 급성기 바이러스 뇌증과 Nterminal pro-B-type natriuretic peptide (NTproBNP)의 증가 소견 이 관련성이 있다는 연구가 보고되었다 13,14) . 급성열성뇌증 2,8,9,20) .…”