Serum neopterin and soluble interleukin-2 receptor for prediction of a shock state in gram-negative sepsis

Delogu, Giovanna; Casula, Milena; Mancini, P; Tellan, Guglielmo; Signore, L

doi:10.1016/0883-9441(95)90018-7

Cited by 26 publications

(9 citation statements)

References 30 publications

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“…Moreover, IL-2 administration is associated with the activation of complement [307–311], neutrophils [311,312], and the coagulation system [313]. Circulating IL-2 receptor concentrations can also predict the likelihood of sepsis in both newborns [314] and adults [315–317]. …”

Section: Discussionmentioning

confidence: 99%

Clinical chorioamnionitis at term IV: the maternal plasma cytokine profile

Romero¹,

Chaemsaithong²,

Docheva³

et al. 2015

Journal of Perinatal Medicine

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Introduction Fever is a major criterion for clinical chorioamnionitis; yet, many patients with intrapartum fever do not have demonstrable intra-amniotic infection. Some cytokines, such as interleukin (IL)-1, IL-6, interferon-gamma (IFN-γ) and tumor necrosis factor-alpha (TNF-α) can induce a fever. The objective of this study was to determine whether maternal plasma concentrations of cytokines could be of value in the identification of patients with the diagnosis of clinical chorioamnionitis at term who have microbial-associated intra-amniotic inflammation. Methods A retrospective cross-sectional study was conducted, including patients with clinical chorioamnionitis at term (n=41; cases) and women in spontaneous labor at term without clinical chorioamnionitis (n=77; controls). Women with clinical chorioamnionitis were classified into three groups according to the results of amniotic fluid cultures, broad-range polymerase chain reaction coupled with electrospray ionization mass spectrometry (PCR/ESI-MS), and amniotic fluid IL-6 concentrations: 1) no intra-amniotic inflammation; 2) intra-amniotic inflammation without detectable microorganisms; or 3) microbial-associated intra-amniotic inflammation. The maternal plasma concentrations of 29 cytokines were determined with sensitive and specific V-PLEX immunoassays. Nonparametric statistical methods were used for analysis, adjusting for a false discovery rate of 5%. Results 1) The maternal plasma concentrations of pyrogenic cytokines (IL-1β, IL-2, IL-6, IFN-γ and TNF-α) were significantly higher in patients with clinical chorioamnionitis at term than in those with spontaneous term labor without clinical chorioamnionitis; 2) the maternal plasma concentrations of cytokines were not significantly different among the three subgroups of patients with clinical chorioamnionitis (intra-amniotic inflammation with and without detectable bacteria and those without intra-amniotic inflammation); and 3) among women with the diagnosis of clinical chorioamnionitis, but without evidence of intra-amniotic inflammation, the maternal plasma concentrations of pyrogenic cytokines were significantly higher than in patients with spontaneous labor at term. These observations suggest that the fever can be mediated by increased circulating concentrations of these cytokines, despite the absence of a local intra-amniotic inflammatory response. Conclusions 1) The maternal plasma concentrations of pyrogenic cytokines (e.g. IL-1β, IL-2, IL-6, IFN-γ and TNF-α) are higher in patients with intra-partum fever and the diagnosis of clinical chorioamnionitis at term than in those in spontaneous labor at term without a fever; and 2) maternal plasma cytokine concentrations have limited value in the identification of patients with bacteria in the amniotic cavity. Accurate assessment of the presence of intra-amniotic infection requires amniotic fluid analysis.

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Section: Discussionmentioning

confidence: 99%

Clinical chorioamnionitis at term IV: the maternal plasma cytokine profile

Romero¹,

Chaemsaithong²,

Docheva³

et al. 2015

Journal of Perinatal Medicine

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“…TLRs have an intracellular domain, homologous with IL-1 and the IL-18 receptors. Adaptor proteins facilitate binding to IL-1 receptor-associated kinase, which in turn induces TNF receptorassociated factor-6, leading to nuclear translocation of nuclear factor-kB (NF-kB) and ultimately to activation of cytokine gene promoters, resulting in advanced proinflammatory cytokine production (Rittisch et al, 2008, Brunn et al, 2006, Cornell et al, 2005, Delogu et al, 1995, Willatts et al, 1994. Initially in inflammatory response, LPS is bound by a lipopolysaccharide binding protein which is located to CD14 and TLR4.…”

Section: Receptor Biomarkersmentioning

confidence: 99%

Biomarkers and Physiological Agents in Severe Sepsis and Septic Shock

Paramythiotis¹,

Digkas²,

Dryllis³

2012

Severe Sepsis and Septic Shock - Understanding a Serious Killer

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“…However, many other conditions elevate blood levels of these analytes, and diagnostic sensitivity and specifi city of individual analyte levels has been insuffi cient for diagnosis of sepsis or severe sepsis ( Delogu et al, 1995 ;Martin et al, 1994 ;Selberg et al, 2000 ). Furthermore, levels of IL-6, IL-8 and IL-2sR have variously shown correlation with sepsis severity, progression to septic shock, organ failure, and mortality.…”

Section: Progression Signaturesmentioning

confidence: 99%