Serum neopterin in acute coronary syndromes

Gupta, Sandeep; Fredericks, Salim; Schwartzman, R. A.; Holt, D W; Kaski, JC

doi:10.1016/s0140-6736(05)62447-6

Cited by 72 publications

(43 citation statements)

References 4 publications

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“…Neopterin (N) is derived by specific monocyte-derived cells including macrophage-dendritic cells, and is considered to be a representative activation marker of macrophages on the stimulation of interferon γ (15). Elevated plasma levels of N were found in patients with coronary artery diseases including stable ischemic heart disease and acute coronary syndrome (16)(17)(18), and it was associated with the progression of coronary heart disease (19). N is considered an independent predictor of heart failure (19).…”

Section: Introductionmentioning

confidence: 99%

Neopterin: A potential marker in chronic peripheral arterial disease

Signorelli

Anzaldi

Fiore

et al. 2013

Molecular Medicine Reports

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Abstract. Neopterin is a marker of macrophage activation that has exhibited high plasma levels in atherosclerotic diseases including coronary heart disease and critical limb ischemia. The role of neopterin in chronic peripheral arterial disease (PAD) has yet to be elucidated. In the present study, neopterin (Ν) serum concentrations were analyzed in asymptomatic (AsP) and symptomatic (SyP) patients with PAD as well as controls (C). In total 120 subjects, 40 AsP [ankle brachial index (ABI) ≤0.90], 40 SyP (ABI ≤0.90 plus pain in legs) and 40 controls (ABI >0.9) were enrolled. The results of the present study showed that neopterin plasma levels were statistically different among the groups. These findings demonstrated that activation of N-mediated monocyte-macrophage, was also observed in chronic PAD.

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Section: Introductionmentioning

confidence: 99%

Neopterin: A potential marker in chronic peripheral arterial disease

Signorelli

Anzaldi

Fiore

et al. 2013

Molecular Medicine Reports

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“…Enfeksiyöz ve inflamatuvar hastalıkların varlığı, ciddiyeti ve progresyonu ile neopterin düzey-leri arasında korelasyon bulunmuştur. Neopterinin aterom plağı-nın aktivitesini gösterdiği de ileri sürülmektedir (30,31). Hem kararlı koroner arter hastalığında hem de akut koroner sendromlarda sağlıklı kontrol grubuyla karşılaştırıldığında neopterin düzeyleri yüksek bulunmuştur (32,33).…”

Section: Discussionunclassified

The relation between exercise- induced myocardial ischemia and high-sensitive C-reactive protein and neopterin levels

Başar¹,

Yaşar²,

Erden³

et al. 2010

Anadolu Kardiyol Derg

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ÖZETAmaç: Yüksek duyarlılıklı C-reaktif protein (hsCRP) ve neopterin, ateroskleroz gelişimi ile ilişkilidir. Bu çalışmada kararlı anjina pektorisli (KAP) hastalarda, egzersiz stres testi (EST) esnasında oluşan miyokart iskemisi ile hsCRP ve neopterin seviyeleri arasındaki ilişki ve EST ile hsCRP ve neopterin düzeylerinde meydana gelen değişimin tıkayıcı koroner lezyon varlığını öngörmedeki yeri araştırılmıştır. Yöntemler: Çalışmamız prospektif, gözlemsel olarak dizayn edildi. Çalışmaya KAP ile takip edilen 45 hasta alındı. Egzersiz stres testi pozitif grupta 23 (15 erkek, yaş ortalaması 54±10 yıl), EST-negatif grupta 22 hasta (14 erkek, yaş ortalaması 52±9 yıl) mevcuttu. Her hastadan EST'den 1 saat önce ve 30 dakika sonra alınan kan örneklerinde hsCRP ve neopterin düzeyleri belirlendi. Egzersiz stres testi pozitif olan hastalara koroner anjiyografi yapılarak tıkayıcı koroner lezyon varlığı ve Gensini skoru ile yaygınlığı değerlendirildi. Bulgular: Egzersiz stres testi öncesi hsCRP ve neopterin düzeyleri iki grup arasında benzer iken EST sonrası hsCRP düzeyleri, EST-pozitif grupta daha yüksek izlendi (p=0.03); neopterin düzeyleri açısından EST sonrasında iki grup arasında fark saptanmadı (p=0.4). Egzersiz stres testi, ESTpozitif olan grupta hem hsCRP, hem de neopterin düzeylerinde anlamlı artışa neden olurken (sırasıyla, 3.8±2.8 mg/L'den 4.3±3.1 mg/L'ye, p=0.001; 8.7±4.0 nmol/L'den 13.1±10.0 nmol/L'ye, p=0.001), egzersiz stres testi negatif olan grupta sadece neopterin düzeylerinde anlamlı artış izlendi (6.9±1.8 nmol/L'den 9.0±3.9 nmol/L'ye, p=0.001). Tıkayıcı koroner lezyon varlığı ve yaygınlığı ile herhangi bir noktada bakılan hsCRP ve neopterin düzeyleri arasında ise anlamlı ilişki izlenmedi. İstatistiksel analiz Ki-kare, eşleştirilmemiş t, Mann-Whitney U ve Wilcoxon rank testleri ile yapıldı. Testlerin öngördürücü değerini belirlemede lojistik regresyon analizi kullanıldı. Sonuç: Kararlı anjina pektorisli hastalarda tıkacı lezyonun varlığından bağımsız olarak pozitif egzersiz testi sonrasında oluşan hsCRP artışı, miyokardiyal iskemi sırasında oluşan immün aktivasyonun bir göstergesi olabilir. (Anadolu Kardiyol Derg 2010 Aralık 1; 10(6): 502-7) Anahtar kelimeler: Egzersiz stres test, kararlı anjina pektoris, hsC-reaktif protein, neopterin, tıkayıcı koroner lezyon, testlerin prediktif değeri ABSTRACT Objective: High sensitivity C-reactive protein (hsCRP) and neopterin are associated with atherosclerosis. We aimed to evaluate the association between hsCRP and neopterin, and myocardial ischemia during exercise stress test (EST) in patients with stable angina pectoris (SAP) and to assess the predictive value of these mediators in obstructive coronary artery disease. Methods: Forty-five patients with SAP were included in this prospective observational study. EST-positive group included 23 patients (15 males, mean age 54±10 years) and EST-negative group-22 patients (14 males, mean age 52±9 years). In each patient, blood samples were obtained 1 hour before and 30 minutes after EST. In EST-positive group, coronary ang...

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“…Additionally, neopterin has been found to mediate the inflammatory process within vulnerable plaques 15,16) . Furthermore, neopterin has been revealed to play a key role in atherosclerotic processes and is related to the presence of unstable coronary lesions in patients with coronary artery disease [19][20][21] . An increased serum level of neopterin has therefore been suggested to be a biomarker of acute widespread atherothrombotic plaque inflammation and CAD activity [19][20][21] .…”

Section: Acute Ischemic Stroke Patients and Healthy Ageand Gender-matmentioning

confidence: 99%

“…Furthermore, neopterin has been revealed to play a key role in atherosclerotic processes and is related to the presence of unstable coronary lesions in patients with coronary artery disease [19][20][21] . An increased serum level of neopterin has therefore been suggested to be a biomarker of acute widespread atherothrombotic plaque inflammation and CAD activity [19][20][21] . Astonishingly, despite the association between an elevated serum level of neopterin and acute coronary syndrome and chronic stable angina 15,16,[19][20][21] , the correlation between the serum neopterin level and carotid artery disease 6,14,[22][23][24] and acute ischemic stroke (AIS) has seldom been reported 25) .…”

Section: Acute Ischemic Stroke Patients and Healthy Ageand Gender-matmentioning

confidence: 99%

“…An increased serum level of neopterin has therefore been suggested to be a biomarker of acute widespread atherothrombotic plaque inflammation and CAD activity [19][20][21] . Astonishingly, despite the association between an elevated serum level of neopterin and acute coronary syndrome and chronic stable angina 15,16,[19][20][21] , the correlation between the serum neopterin level and carotid artery disease 6,14,[22][23][24] and acute ischemic stroke (AIS) has seldom been reported 25) . Therefore, the present study tested the potential of the serum neopterin concentration as a clinical biomarker to reflect the severity of extracranial carotid artery (ECCA) stenosis and further tested whether there is a correlation between an increased circulating level of neopterin and plaque instability.…”

Section: Acute Ischemic Stroke Patients and Healthy Ageand Gender-matmentioning

confidence: 99%

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Levels of Circulating Neopterin in Patients with Severe Carotid Artery Stenosis Undergoing Carotid Stenting

Chen

Tsai

Sung

et al. 2014

JAT

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Aims:The association between an elevated serum neopterin level and the development of coronary artery complex lesions has been extensively assessed; however, the correlation between the serum neopterin level and the development of carotid artery stenosis has seldom been reported. This study tested whether this biomarker is increased in patients with severe carotid artery stenosis (≥ 70%) undergoing carotid artery (CA) stenting and investigated independent predictors of an increased circulating neopterin level. Methods: Fifty patients with severe CA stenosis (CAS) undergoing CA stenting were consecutively enrolled in this study from January 2009 through December 2011. The serum neopterin levels of age-and gender-matched acute ischemic stroke (AIS) patients (n = 120) and control subjects (CS) (n=33) were also measured. A blood sample was prospectively collected from each patient in the catheterization room. Results: The serum levels of neopterin were significantly higher in the CAS patients than in the AIS patients or CS and significantly higher in the AIS patients than in the CS (all p＜0.001). An analysis of the variables of 170 patients (CAS＋AIS) demonstrated that age, a previous history of stroke and severe CAS were significantly correlated with an increased serum level of neopterin (all p＜0.005). A multivariate binary logistic regression analysis of the severe CAS patients (n = 50) demonstrated that age and the creatinine level were independent predictors of a high neopterin level (neopterin level ≥ 16.52 ng/dL, i.e., according to the median value of neopterin) (all p＜0.05). Conclusions: The circulating neopterin levels are significantly higher in patients with severe CAS than in those with AIS. The presence of CAS, age and the creatinine level were significantly correlated with an increased serum neopterin level.

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Serum neopterin in acute coronary syndromes

Cited by 72 publications

References 4 publications

Neopterin: A potential marker in chronic peripheral arterial disease

Neopterin: A potential marker in chronic peripheral arterial disease

The relation between exercise- induced myocardial ischemia and high-sensitive C-reactive protein and neopterin levels

Levels of Circulating Neopterin in Patients with Severe Carotid Artery Stenosis Undergoing Carotid Stenting

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