Serum neuron‐specific enolase in metastatic merkel cell tumors

Abstract

Three patients with widely disseminated Merkel cell tumors of the skin are presented. In all three cases, neuron-specific enolase (NSE) was demonstrated in neoplastic tissue by immunohistochemical staining, and serum NSE levels were also elevated in all three patients. Serum NSE may prove to be a useful tumor marker in this and other malignancies of neuroendocrine origin.

Clinical emergence of neurometastatic merkel cell carcinoma: a surgical case series and literature review

“…Five of these cases were reported in the context of case series for which individual patient data was not available [18, 21, 29]. Several duplicate cases were identified which had been previously published [22, 23]. The mean age of patients was 63 ± 11 years.…”

Stereotactic radiosurgery for merkel cell carcinoma brain metastases

“…Brain metastasis from MCC is extremely rare and only a few patients have been described in the literature (Table 1) [4][5][6][7][8]. The optimal treatment for these tumors is still unknown but the general recommendation consists of aggressive management.…”

Merkel cell carcinoma of the abdominal wall

“…MCC is radiosensitive and radiotherapy is currently used as an adjunct to surgery. [ 16 ] It is used as primary therapy only in inoperable cases and when the patient refuses surgery. In the present case, wide local excision with 2 cm margin along with regional lymph node dissection was done.…”