Serum neutralization of SARS coronavirus 2 Omicron sublineages BA.1 and BA.2 and cellular immune responses 3 months after booster vaccination

Alidjinou, Enagnon Kazali; Demaret, Julie; Corroyer-Simovic, Bénédicte; Vuotto, Fanny; Miczek, Sophie; Labreuche, Julien; Goffard, Anne; Trauet, Jacques; Lupau, Daniela; Dendooven, Arnaud; Huvent‐Grelle, Dominique; Podvin, Juliette; Dreuil, Daniel; Faure, Karine; Deplanque, Dominique; Bocket, Laurence; Duhamel, Alain; Sobaszek, Annie; Hober, Didier; Hisbergues, Michael; Puisieux, François; Autran, Brigitte; Yazdanpanah, Yazdan; Labalette, Myriam; Lefèvre, Guillaume

doi:10.1016/j.cmi.2022.10.014

Cited by 2 publications

(1 citation statement)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Omicron variant is characterized by great antigenic variability due to the selection of 37 mutations in the spike protein, the main immunogenic protein of the virus, and it is capable of inducing the production of neutralizing antibodies [41,42]. However, significant protection against Omicron has been shown at least within a short time after a booster dose, but the initial elevation in the NtAbs titers was followed by a remarkable decline over time [39,43,44]. These results raised concerns about the potential protective efficacy of antibodies against Omicron over time [45,46], justifying the need for the periodic administration of booster doses and the production of vaccines based on newly emerging variants.…”

Section: Discussionmentioning

confidence: 99%

An Analysis of the Neutralizing Antibodies against the Main SARS-CoV-2 Variants in Healthcare Workers (HCWs) Vaccinated against or Infected by SARS-CoV-2

Immordino,

Pisciotta,

Amodio

et al. 2023

Vaccines

View full text Add to dashboard Cite

Although the anti-COVID-19 vaccination has proved to be an effective preventive tool, “breakthrough infections” have been documented in patients with complete primary vaccination courses. Most of the SARS-CoV-2 neutralizing antibodies produced after SARS-CoV-2 infection target the spike protein receptor-binding domain which has an important role in facilitating viral entry and the infection of the host cells. SARS-CoV-2 has demonstrated the ability to evolve by accumulating mutations in the spike protein to escape the humoral response of a host. The aim of this study was to compare the titers of neutralizing antibodies (NtAbs) against the variants of SARS-CoV-2 by analyzing the sera of recovered and vaccinated healthcare workers (HCWs). A total of 293 HCWs were enrolled and divided into three cohorts as follows: 91 who had recovered from SARS-CoV-2 infection (nVP); 102 that were vaccinated and became positive after the primary cycle (VP); and 100 that were vaccinated with complete primary cycles and concluded the follow-up period without becoming positive (VN). Higher neutralization titers were observed in the vaccinated subjects’ arms compared to the nVP subjects’ arms. Differences in neutralization titers between arms for single variants were statistically highly significant (p < 0.001), except for the differences between titers against the Alpha variant in the nVP and in VP groups, which were also statistically significant (p < 0.05). Within the nVP group, the number of subjects with an absence of neutralizing antibodies was high. The presence of higher titers in patients with a complete primary cycle compared to patients who had recovered from infection suggested the better efficacy of artificial immunization compared to natural immunization, and this further encourages the promotion of vaccination even in subjects with previous infections.

show abstract

Section: Discussionmentioning

confidence: 99%

An Analysis of the Neutralizing Antibodies against the Main SARS-CoV-2 Variants in Healthcare Workers (HCWs) Vaccinated against or Infected by SARS-CoV-2

Immordino,

Pisciotta,

Amodio

et al. 2023

Vaccines

View full text Add to dashboard Cite

show abstract

An Analysis of the Neutralizing Antibodies Against the Main SARS-CoV-2 Variants in Healthcare Workers (HCWs) Vaccinated Against or Infected by SARS-CoV-2

Immordino,

Pisciotta,

Amodio

et al. 2023

Preprint

View full text Add to dashboard Cite

Although the anti-COVID-19 vaccination has proved to be an effective preventive tool, "break-through infections" have been documented in patients with complete primary vaccination course. Most of the SARS-CoV-2 neutralizing antibodies pro-duced after SARS-CoV-2 infection target the spike protein receptor-binding domain which has an important role in facilitating viral entry and infection of the host cells. SARS-CoV-2 has demonstrated the ability to evolve by accumulating mutations in the spike protein to escape the humoral response of the host. The aim of this study is to compare the titers of neutralizing an-tibodies against the variants of SARS-CoV-2 by analyzing the sera of recovered and vaccinated healthcare workers (HCWs). 293 HCWs were enrolled and divided into three cohorts as follows: 91 recovered from SARS-CoV-2 infection (nVP); 102 vac-cinated who became positive after the primary cycle (VP); 100 vaccinated with complete primary cycle who concluded the follow-up pe-riod without becoming positive (VN). Higher neutraliza-tion titers were observed in the vaccinated subjects’ arms com-pared to the nVP arm. Differences in neutralization titers between arms for single variant were statistically significant (p<0.001) except for titers against the Alpha variant (p<0.05) between nVP and VP. Within the nVP group, the number of subjects with the absence of neutralizing antibodies was high. The presence of high-er titers in patients with a complete primary cycle compared to patients recovered from the infec-tion suggests a better efficacy of artificial immunization compared to natural im-munization, further encouraging the promotion of vaccination even in subjects with previous infection.

show abstract

Serum neutralization of SARS coronavirus 2 Omicron sublineages BA.1 and BA.2 and cellular immune responses 3 months after booster vaccination

Cited by 2 publications

References 18 publications

An Analysis of the Neutralizing Antibodies against the Main SARS-CoV-2 Variants in Healthcare Workers (HCWs) Vaccinated against or Infected by SARS-CoV-2

An Analysis of the Neutralizing Antibodies against the Main SARS-CoV-2 Variants in Healthcare Workers (HCWs) Vaccinated against or Infected by SARS-CoV-2

An Analysis of the Neutralizing Antibodies Against the Main SARS-CoV-2 Variants in Healthcare Workers (HCWs) Vaccinated Against or Infected by SARS-CoV-2

Contact Info

Product

Resources

About