Serum neutrophil gelatinase-associated lipocalin for predicting anemia of inflammation in children with urinary tract infection

Abstract

anemia of inflammation (ia), the second most common cause of childhood anemia, results from macrophage iron sequestration and impaired erythropoiesis. neutrophil gelatinase-associated lipocalin (nGaL) plays an important role in innate microbial immunity through its influence on intracellular iron homeostasis and inhibition of erythropoiesis. The predictive value of nGaL in ia was assessed in 74 children (age 6.30 ±3.64 ci): 1.128 (1.005-1.265), p = 0.040]. in stepwise multiple analysis age independently correlated with rBc (β = 0.051, p = 0.001), while crP independently correlated with HgB (β = -0.037, p = 0.027) and rBc (β = -0.022, p = 0.014). roc analysis demonstrated better diagnostic profiles for crP, procalcitonin (Pct) and fever duration for predicting the risk of ia than ngal (auc: 0.690, 0.669, 0.678 vs. 0.638, respectively). Despite the increase in HgB levels after 4-5 weeks from the onset of uti, HgB values were still significantly lower in the anemic than in non-anemic children. ngal was not useful for predicting ia in uti, since its diagnostic value was inferior to conventional inflammatory markers. months) with the first episode of urinary tract infection (uti). anemia of inflammation was found in 50% of children, including those with non-febrile uti, and delayed onset of anemia was observed in 20% of children. There were no differences in nGaL levels between the anemic and non-anemic children, and no correlations between ngal and hemoglobin (HgB) levels and red blood cell (rBc) count. in multivariate logistic regression analysis elevated c-reactive protein (crP) was only independently associated with the presence of anemia in children with uti [or (95%

Lipocalin-2, Soluble Transferrin Receptor, and Erythropoietin in Anemia During Mild Renal Dysfunction

“… 26 , 27 In contrast, in another study, there was no significant difference in LCN2 levels between anemic and non-anemic subjects, and there was no significant association between LCN2 and hemoglobin levels. 28 In our study, hemoglobin levels were significantly lower in patients with elevated LCN2 levels than in those without elevated LCN2 levels. Moreover, compared with non-anemic individuals, patients with anemia had significantly higher LCN2 levels.…”

Lipocalin-2: a novel link between the injured kidney and the bone

“…Subsequent studies have shown the existence of mammalian siderophores that LCN2 also binds, suggesting that LCN2 might be involved in the regulation of systemic and local iron metabolism. Consequently, several studies have shown strong association between iron metabolism, hematological indices, and LCN2 concentration [91 ▪ ,92,93]. LCN2 appears to regulate tissue-specific iron balance [94–96], and might play a pivotal role in the protection of tissue against high free iron levels.…”