Serum NfL as an MS biomarker

Kiani, Lisa

doi:10.1038/s41582-022-00760-4

Cited by 2 publications

(2 citation statements)

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“…A recent clinical cross‐sectional study demonstrated a correlation between alterations in the gut microbiome composition of patients with AD and β‐amyloid and tau pathological biomarkers, suggesting that changes in the gut microbiome may occur early in the disease process and have an association with cognitive impairment. Probiotics may mitigate COVID‐19‐induced cognitive impairments through the regulation of neuroinflammation, modulation of the gut microbiota, and gut homeostasis 175,176 . Overall, probiotics have important research potential and value in improving COVID‐19‐related cognitive impairment in the elderly, potentially via their complex regulation of various physiological processes (Figures 1 and 6).…”

Section: Microbiota‐based Implications For Therapeutic Interventionsmentioning

confidence: 99%

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

Qiu,

Mo,

Chen

et al. 2024

MedComm

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Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) recently caused a global pandemic, resulting in more than 702 million people being infected and over 6.9 million deaths. Patients with coronavirus disease (COVID‐19) may suffer from diarrhea, sleep disorders, depression, and even cognitive impairment, which is associated with long COVID during recovery. However, there remains no consensus on effective treatment methods. Studies have found that patients with COVID‐19 have alterations in microbiota and their metabolites, particularly in the gut, which may be involved in the regulation of immune responses. Consumption of probiotics may alleviate the discomfort caused by inflammation and oxidative stress. However, the pathophysiological process underlying the alleviation of COVID‐19‐related symptoms and complications by targeting the microbiota remains unclear. In the current study, we summarize the latest research and evidence on the COVID‐19 pandemic, together with symptoms of SARS‐CoV‐2 and vaccine use, with a focus on the relationship between microbiota alterations and COVID‐19‐related symptoms and vaccine use. This work provides evidence that probiotic‐based interventions may improve COVID‐19 symptoms by regulating gut microbiota and systemic immunity. Probiotics may also be used as adjuvants to improve vaccine efficacy.

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Section: Microbiota‐based Implications For Therapeutic Interventionsmentioning

confidence: 99%

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

Qiu,

Mo,

Chen

et al. 2024

MedComm

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“…Neurofilament light chain (NfL) is a cytoskeletal protein of nerve axons that could be detected in cerebrospinal fluid and serum in response to neuronal damage, including neuroinflammation and neurodegeneration ( Disanto et al, 2017 ; Mollenhauer et al, 2020 ). Serum neurofilament light chain (sNfL) is a promising biomarker of neuroaxonal injury in patients with MS, as it is closely correlated with relapsing activities, disability deterioration, brain shrinkage and therapy response ( Barro et al, 2018 ; Kuhle et al, 2019 ; Kiani, 2023 ). However, the relationship between NfL and APTw, DTI parameters remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Altered amide proton transfer weighted and diffusion signals in patients with multiple sclerosis: correlation with neurofilament light chain and disease duration

et al. 2023

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ObjectivesTo compare the signal alterations of amide proton transfer (APT), apparent diffusion coefficient (ADC), and fractional anisotropy (FA) in white matter (WM) lesions in multiple sclerosis (MS), compared with healthy controls (HCs), and to investigate the relationships between these changes and clinical measurements such as serum neurofilament light chain (sNfL).Materials and methodsTwenty-nine patients with relapsing-remitting MS (21 females and 8 males) and 30 HCs (23 females and 7 males) were recruited. APT-weighted (APTw) and diffusion tensor imaging (DTI) data were acquired using a 3.0-T magnetic resonance system. APTw and DTI images were registered to FLAIR-SPIR images and assessed by two neuroradiologists. MTRasym (3.5 ppm), ADC, FA values for MS and HC are calculated using mean values from all regions of interest (ROI). The ROI criteria were: (1) for MS patients, ROI were defined as MS lesions, and each lesion was identified. (2) The WM around each HC’s lateral ventricle (frontal lobe, parietal lobe, and centrum semiovale) was assessed bilaterally. The diagnostic efficacy of MTRasym (3.5 ppm), ADC, and FA in the lesions of MS patients was compared using receiver operating characteristic (ROC) curve analysis. The associations between MTRasym (3.5 ppm), ADC, and FA values and the clinical measurements were investigated further.ResultsThe MTRasym (3.5 ppm) and ADC values of brain lesions were increased, while FA values were decreased in patients with MS. The diagnostic area under curve (AUC) of MTRasym (3.5 ppm), ADC, and FA value was 0.891 (95% CI: 0.813, 0.970), 0.761 (95% CI: 0.647, 0.875) and 0.970 (95% CI: 0.924, 1.0), respectively. sNfL was considerably positively correlated with MTRasym (3.5 ppm) (P = 0.043, R = 0.38) and disease durations were significantly negatively correlated with FA (P = 0.046, R = −0.37).ConclusionAmide proton transfer-weighted (APTw) and DTI are potential imaging methods for assessing brain lesions in patients with MS at the molecular and microscopic levels, respectively. The association between APTw, DTI parameters and clinical factors implies that they may play a role in disease damage monitoring.

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Serum NfL as an MS biomarker

Cited by 2 publications

References 1 publication

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

Alterations in microbiota of patients with COVID‐19: implications for therapeutic interventions

Altered amide proton transfer weighted and diffusion signals in patients with multiple sclerosis: correlation with neurofilament light chain and disease duration

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