Serum omentin-1 and chemerin levels are interrelated in patients with Type 2 diabetes mellitus with or without ischaemic heart disease

El‐Mesallamy, Hala O.; El-Derany, Marwa O.; Hamdy, Nadia M.

doi:10.1111/j.1464-5491.2011.03353.x

Cited by 120 publications

(107 citation statements)

References 28 publications

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“…Serum chemerin levels were found to be significantly increased in patients with Type 2 diabetes and obese patients [18,19]. But some researchers have different opinions in pregnant women.…”

Section: Discussionmentioning

confidence: 97%

Chemerin expression in Chinese pregnant women with and without gestational diabetes mellitus

et al. 2015

Annales d'Endocrinologie

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“…Serum chemerin levels were found to be significantly increased in patients with Type 2 diabetes and obese patients [18,19]. But some researchers have different opinions in pregnant women.…”

Section: Discussionmentioning

confidence: 97%

Chemerin expression in Chinese pregnant women with and without gestational diabetes mellitus

et al. 2015

Annales d'Endocrinologie

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“…IL-6 was negatively associated with omentin-1 in type 2 diabetes mellitus. 19 Moreover, the change in highsensitivity CRP levels were found to be the only variable negatively correlated with serum omentin-1 levels after metformin treatment in PCOS women. 33 CKD is linked to higher risk of CVD and mortality because of a variety of complex deleterious alterations in physiologic and metabolic functions such as IR, inflammation, malnutrition, anemia, and vitamin D deficiency along with classical risk factors.…”

Section: Discussionmentioning

confidence: 99%

“…Also, it is negatively correlated with metabolic risk factors and inflammation. [13][14][15][16][17][18][19] Recent reports have usually demonstrated an inverse association between omentin-1 and atherosclerosis (AS). 18,[20][21][22][23] Little is known about omentin-1 in CKD.…”

Section: Introductionmentioning

confidence: 99%

Serum omentin-1, inflammation and carotid atherosclerosis in patients with non-diabetic chronic kidney disease

Şengül¹,

Duygulu²,

Dindar³

et al. 2013

Renal Failure

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Background and aim: Omentin-1 is suggested to affect inversely atherosclerosis (AS). Data about omentin-1 is limited to chronic kidney disease (CKD). Our aim was to examine omentin-1 in non-diabetic CKD patients who are not dialyzed and investigate its relationships with inflammation and carotid AS. Materials and Methods: We performed a cross-sectional study in 55 non-diabetic CKD patients and 30 healthy controls. Baseline clinical and laboratory data were obtained for all participants. Serum omentin-1 and interleukin-6 (IL-6) levels were measured according to the manufacturer's instructions. Carotic plaque and intima-media thickness (IMT) were assessed by carotid ultrasonography. The homeostasis model assessment of insulin resistance index (HOMA-IR) was used to assess IR. Results: Omentin-1 and IL-6 levels in the patient group were found to be higher than the control group; the differences were statistically significant (p ¼ 0.01 and p ¼ 0.04, respectively). Carotid IMT(mean) was significantly higher in the patient group (p ¼ 0.01). Omentin-1 did not correlate with IL-6 and IMT in the patient group (p ¼ 0.51 and p ¼ 0.76, respectively). In subgroup analysis, omentin-1 levels in patients with carotid plaque were lower than those without carotid plaque (179.5 AE 88.1 ng/ml and 185.9 AE 67.8 ng/ml, respectively). However, the difference was not statistically significant (p ¼ 0.47). Conclusion: We conclude that omentin-1 is higher in not dialyzed non-diabetic CKD and there is no correlation between omentin-1 and IL-6 or carotid IMT(mean).

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“…Paradoxically, while omentin is highly expressed in visceral fat tissue, circulating plasma omentin concentrations were shown to be downregulated in obesity-linked metabolic disorders, including insulin resistance, glucose intolerance, and type 2 diabetes (1,9). In obese and metabolically afflicted people, omentin was positively correlated with adiponectin and high-density lipoprotein cholesterol and inversely correlated with triglyceride and leptin levels (10)(11)(12)(13)(14). The underlying regulatory mechanisms mediating omentin dysregulation in obesity are unknown, but could potentially include adipocyte hypertrophy, inflammation, and oxidative stress, as well as a failure of transcriptional regulation.…”

Section: Introductionmentioning

confidence: 99%

Circulating Omentin as a Novel Biomarker for Colorectal Cancer Risk: Data from the EPIC–Potsdam Cohort Study

et al. 2016

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Omentin is a novel biomarker shown to exert metabolic, inflammatory, and immune-related properties and thereby could be implicated in the risk of colorectal cancer. So far, the association between omentin and colorectal cancer risk has not been evaluated in prospective cohort studies. We investigated the association between prediagnostic plasma omentin concentrations and risk of colorectal cancer in a case-cohort comprising 251 incident colorectal cancer cases diagnosed over a mean follow-up time of 10.4 years and 2,295 persons who remained free of cancer in the European Prospective Investigation into Cancer and Nutrition-Potsdam study. Hazard ratios as a measure of relative risk (RR) and 95% confidence intervals (CI) were computed using a Prentice-modified Cox regression. In a multivariable model adjusted for age, sex, education, dietary and lifestyle factors, body mass index (BMI), and waist circumference, higher omentin concentrations were associated with a higher colorectal cancer risk (RR continuously per doubling of omentin concentrations ¼ 1.98; 95% CI, 1.45-2.73). Additional adjustment for metabolic biomarkers, including glycated hemoglobin, high-density lipoprotein cholesterol, and C-reactive protein, did not alter the results. In stratified analyses, the positive association between omentin and colorectal cancer risk was retained in participants with BMI < 30 (RR continuously per doubling of omentin concentrations ¼ 2.26; 95% CI, 1.57-3.27), whereas among participants with BMI ! 30 no association was revealed (RR continuously per doubling of omentin concentrations ¼ 1.07; 95% CI, 0.63-1.83; P interaction ¼ 0.005). These novel findings provide the first lines of evidence for an independent association between prediagnostic omentin concentrations and colorectal cancer risk and suggest a potential interaction with the adiposity state of the individual. Cancer Res; 76(13); 3862-71. Ó2016 AACR.

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Serum omentin-1 and chemerin levels are interrelated in patients with Type 2 diabetes mellitus with or without ischaemic heart disease

Cited by 120 publications

References 28 publications

Chemerin expression in Chinese pregnant women with and without gestational diabetes mellitus

Chemerin expression in Chinese pregnant women with and without gestational diabetes mellitus

Serum omentin-1, inflammation and carotid atherosclerosis in patients with non-diabetic chronic kidney disease

Circulating Omentin as a Novel Biomarker for Colorectal Cancer Risk: Data from the EPIC–Potsdam Cohort Study

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