Serum omentin-1 is a novel biomarker for predicting the functional outcome of acute ischemic stroke patients

Xu, Tian; Zuo, Peng; Gao, Zhiwei; Ke, Kaifu

doi:10.1515/cclm-2017-0282

Cited by 20 publications

(14 citation statements)

References 30 publications

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“…In line with the preclinical studies, cross-sectional studies reported that circulating omentin concentrations were lower in people with coronary artery disease or ischaemic stroke compared with individuals without cardiovascular disease [10,[35][36][37][38][39][40]. Lower omentin concentrations were also related to less favourable short-term functional outcome in individuals with ischaemic stroke [39].…”

Section: Association Between Omentin and Cardiovascular Outcomesmentioning

confidence: 57%

Higher circulating omentin is associated with increased risk of primary cardiovascular events in individuals with diabetes

et al. 2019

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Aims/hypothesis Higher concentrations of the adipokine omentin are associated with lower levels of cardiometabolic risk factors in experimental and cross-sectional studies, but with higher risk of type 2 diabetes and cardiovascular diseases in population-based cohort studies. However, it is unknown whether high omentin concentrations are associated with increased risk of cardiovascular events in people with established diabetes. Therefore, the present study investigated the association between serum omentin concentrations and the risk of cardiovascular events in individuals with diabetes. Methods This prospective study was based on participants of the German ESTHER cohort with diabetes and without previous cardiovascular event. The ESTHER cohort consists of individuals aged 50-75 years at baseline who were recruited by their general practitioners. After exclusion of individuals with serum C-reactive protein ≥10 mg/l (≥95.24 nmol/l), the final analysis population consisted of 933 individuals. At baseline, serum omentin concentrations were measured by ELISA. Cox regression models were fitted to estimate HRs and their corresponding 95% CIs for associations of omentin tertiles with a composite endpoint of cardiovascular events and separately with incident myocardial infarction, stroke and cardiovascular death. Results During 14 years of follow-up, 228 individuals experienced a primary cardiovascular event (myocardial infarction, stroke or cardiovascular death). After comprehensive adjustment for age, sex, BMI, metabolic and lifestyle factors and medication use, HRs (95% CIs) for the 2nd and 3rd tertile of omentin compared with the 1st tertile were: 1.24 (95% CI 0.86, 1.79) and 1.63 (1.15, 2.32) (p trend = 0.005) for the composite cardiovascular endpoint; 1.39 (0.78, 2.47) and 1.71 (0.98, 2.99) (p trend = 0.065) for incident myocardial infarction; 1.40 (0.78, 2.53) and 2.05 (1.17, 3.58) (p trend = 0.010) for incident stroke; and 1.43 (0.85, 2.40) and 1.72 (1.04, 2.83) (p trend = 0.040) for cardiovascular death. Effect estimates and p values were almost unaltered after additional adjustment for adiponectin. Conclusions/interpretation Higher omentin concentrations are associated with an increased risk for cardiovascular events in individuals with diabetes after adjustment for multiple cardiovascular risk factors. Given data from preclinical studies, it appears possible that this association reflects a compensatory, but insufficient upregulation of omentin concentrations as a response to stimuli that increase cardiovascular risk.

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Section: Association Between Omentin and Cardiovascular Outcomesmentioning

confidence: 57%

Higher circulating omentin is associated with increased risk of primary cardiovascular events in individuals with diabetes

et al. 2019

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“…With respect to CVD, circulating omentin was decreased in patients with coronary artery disease and appeared to have a protective role in patients with ischaemic stroke . In line, administration of omentin in mice reduced tissue damage after ischaemia/reperfusion and delayed the development of aortic atherosclerotic lesions with reduced vascular inflammation …”

Section: Introductionmentioning

confidence: 72%

“…1 With respect to CVD, circulating omentin was decreased in patients with coronary artery disease 6,7 and appeared to have a protective role in patients with ischaemic stroke. 8,9 In line, administration of omentin in mice reduced tissue damage after ischaemia/reperfusion 10 and delayed the development of aortic atherosclerotic lesions with reduced vascular inflammation. 11 In contrast with the findings from cross-sectional and experimental studies, the prospective analysis within the KORA F4/FF4 cohort indicated that higher circulating omentin is associated with a higher risk of T2D.…”

Section: Introductionmentioning

confidence: 87%

Omentin‐regulated proteins combine a pro‐inflammatory phenotype with an anti‐inflammatory counterregulation in human adipocytes: A proteomics analysis

Niersmann

Hauck

Kannenberg

et al. 2018

Diabetes Metabolism Res

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In differentiated human adipocytes, the release of the anti-inflammatory TNFAIP6 might be part of a counterregulatory response to the pro-inflammatory action of omentin. Omentin-regulated proteins were overrepresented in pathways indicating cellular stress, a pro-inflammatory environment and a crosstalk with other organs. Other potential activators of omentin-regulated proteins point towards a central role of NFκB activation in the omentin-induced secretory process.

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“…Some population studies reported that omentin-1 was significantly associated with carotid atherosclerosis among metabolic syndrome subjects and type 2 diabetes patients 4 , 5 ) . Our previous study has also demonstrated that higher omentin-1 levels at baseline were inversely associated with poor functional outcome among ischemic stroke patients 6 ) . To date, no study has specifically evaluated the association between omentin-1 levels and carotid atherosclerosis among ischemic stroke patients.…”

Section: Introductionmentioning

confidence: 84%

Omentin-1 is Associated with Carotid Plaque Instability among Ischemic Stroke Patients

Zuo

Cao

et al. 2018

JAT

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Aims: Omentin-1 was proved to be associated with ischemic stroke clinical functional outcome. It also predicted carotid atherosclerosis among metabolic syndrome subjects and type 2 diabetes patients. Our aim was to examine the association of omentin-1 levels with carotid plaque instability and stenosis degree among ischemic stroke patients.Methods: A total of 173 acute ischemic stroke patients were included in this study. Serum omentin-1 levels were assayed. Carotid ultrasound examinations were performed to evaluate the carotid plaque instability and stenosis degree. Multivariable logistic analyses were used to examine the association of serum omentin-1 levels with carotid plaque instability and stenosis degree.Results: Ischemic stroke patients with unstable carotid plaque had significantly lower levels of serum omentin-1 than patients with stable plaque (53 [40.2–64.1] vs 61.8 [52.4–77.2] ng/ml, P < 0.01). Subjects in the highest tertile of serum omentin-1 levels had a 0.31-fold risk of having unstable plaque compared with those in the lowest tertile (P < 0.05), and its trend test was significant (P for trend = 0.03). The integrated discrimination improvement was significantly improved in predicting carotid plaque instability when omentin-1 data was added to the multivariable logistic regression model. No significant association was detected between omentin-1 and moderate-severe carotid stenosis or occlusion.Conclusions: Among ischemic stroke patients, higher omentin-1 levels were inversely associated with carotid plaque instability, but not associated with moderate-severe carotid stenosis or occlusion. Omentin-1 may represent a biomarker for predicting carotid plaque instability of acute ischemic stroke patients.

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Serum omentin-1 is a novel biomarker for predicting the functional outcome of acute ischemic stroke patients

Abstract: Higher omentin-1 levels at baseline were negatively associated with poor functional outcome among ischemic stroke patients. Omentin-1 may represent a biomarker for predicting poor functional outcome of acute ischemic stroke patients.

Cited by 20 publications

References 30 publications

Higher circulating omentin is associated with increased risk of primary cardiovascular events in individuals with diabetes

Higher circulating omentin is associated with increased risk of primary cardiovascular events in individuals with diabetes

Omentin‐regulated proteins combine a pro‐inflammatory phenotype with an anti‐inflammatory counterregulation in human adipocytes: A proteomics analysis

Omentin-1 is Associated with Carotid Plaque Instability among Ischemic Stroke Patients

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