Serum omentin-1 levels are inversely associated with the presence and severity of coronary artery disease in patients with metabolic syndrome

Shang, Fei; Wang, Jie-Pin; Liu, Xiongtao; Zheng, Qiangsun; Xue, Yan; Wang, Bin; Zhao, Lina

doi:10.3109/1354750x.2011.622789

Cited by 77 publications

(50 citation statements)

References 17 publications

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“…De Souza et al (26) showed that omentin gene expression was decreased with obesity and decreased omentin levels were associated with increasing obesity and insulin resistance. Furthermore, serum omentin-1 levels were shown to be inversely associated with the presence and severity of coronary artery disease in patients with metabolic syndrome (27). This data showed that there may be a putative role of human omentin gene missense variation in patients with cardiovascular disease.…”

Section: Discussionmentioning

confidence: 71%

Association of omentin Val109Asp polymorphism with coronary artery disease

Yörük¹,

Yaykaşlı²,

Özhan³

et al. 2014

Anadolu Kardiyol Derg

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Section: Discussionmentioning

confidence: 71%

Association of omentin Val109Asp polymorphism with coronary artery disease

Yörük¹,

Yaykaşlı²,

Özhan³

et al. 2014

Anadolu Kardiyol Derg

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“…In patients with metabolic syndrome, omentin-1 levels inversely correlated with the presence and angiographic severity of CAD (ref. 11 ). Another interesting new observation in our study is that omentin-1 levels in CAD patients did not differ between patients with acute myocardial infarction and patients in the chronic phase of CAD.…”

Section: Discussionmentioning

confidence: 99%

Omentin-1 levels in patients with premature coronary artery disease, metabolic syndrome and healthy controls. Short communication

Stejskal

Václavík

Smékal

et al. 2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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Objectives. Omentin-1 is an adipokine which could have a protective role against the manifestation of atherosclerosis. Only limited data are available on omentin-1 serum values in patients with premature clinical manifestations of atherosclerosis.Design and Methods. We tested omentin-1 in human serum by ELISA method in 61 individuals with a premature manifestation of coronary artery disease (CAD), 40 patients with metabolic syndrome and 40 healthy control subjects. Results. Omentin-1 serum levels were significantly lower in patients with CAD (103.1±62.7 mg/L) compared to metabolic syndrome (668.2±339.6 mg/L) and healthy subjects (623.0±373.5 mg/L) (P < 0.01). In CAD patients, omentin-1 serum levels did not differ between patients sampled in the acute phase of myocardial infarction (n = 28; 110.3±82.4 mg/L) and in the chronic phase several months or years after myocardial infarction (n = 33; 97.0±39.3 mg/L) (P = 0.41). We found a weak positive correlation between omentin-1 and body mass index (r = 0.21, P = 0.014). No significant correlation was found between peak cardiac troponin T and omentin-1 (correlation coefficient r = 0.118, P = 0.406). Conclusion. Serum omentin-1 seems to be a useful biomarker of coronary artery disease across the whole age spectrum.

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“…Także Ismail i Mohamed zwrócili uwagę na mniejsze stężenie omentyny u chorych na łuszczycę. Ze względu na jej protekcyjną rolę w przeciwdziałaniu tworzeniu się blaszki miażdży-cowej w naczyniach wieńcowych i w rozwoju innych zaburzeń naczyniowych wynikających z otyłości badacze zasugerowali, że jej małe stężenie u pacjentów z łuszczycą może się przyczyniać do częstszego występowania powikłań naczyniowych u tych chorych [41,42]. Przedstawione badania wykazują, że małe stężenie omentyny może odgrywać rolę w powstawaniu stanu zapalnego, co z kolei może powodować rozwój zarówno łuszczycy, jak i towarzyszących jej zaburzeń metabolicznych i naczyniowych.…”

Section: Vaspinunclassified

“…Ismail and Mohamed have also highlighted lower concentrations of omentin in psoriatic patients. Taking into account the protective role of omentin both in the prevention of atheromatous plaque deposition in coronary vessels and the development of other obesity-related vascular disorders, the researchers have suggested that low omentin levels in patients with psoriasis may be a factor contributing to a greater incidence of vascular complications in this patient group [41,42]. The studies presented above suggest that a low concentration of omentin may be a factor in the emergence of inflammation, which in turn may contribute both to the development of psoriasis and metabolic and vascular disorders accompanying it.…”

Section: Omentynamentioning

confidence: 99%

Role of omentin and vaspin in metabolic diseases in association with psoriasis

Kiluk¹,

Baran²,

Flisiak³

2017

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Psoriasis is a chronic skin disease characterized by systemic inflammation associated with an increased risk of metabolic and cardiovascular complications. A special role in maintaining systemic inflammation is attributed to obesity. Adipose tissue is an active endocrine organ which, through adipokine secretion, is involved in the regulation of many systemic metabolic pathways. Obesity increases the risk of developing type 2 diabetes mellitus, atherosclerosis, cardiovascular diseases and hypertension. The paper presents the characteristics of two relatively recently discovered and little known adipokines: omentin and vaspin. They are considered to have beneficial effects preventing the development of metabolic disorders associated with obesity. In addition, attention was given to their possible involvement in the pathogenesis of psoriasis and potential use as markers of disease severity and the risk of developing metabolic complications. stReszczenIe Łuszczyca jest przewlekłą chorobą skóry, w której ogólnoustrojowy stan zapalny wiąże się ze zwiększonym ryzykiem rozwoju powikłań metabolicznych i sercowo-naczyniowych. Szczególne znaczenie w podtrzymaniu stanu zapalnego w organizmie ma otyłość. Tkanka tłuszczo-wa jest aktywnym organem endokrynnym, który poprzez wydzielane adipokiny bierze udział w regulacji licznych szlaków metabolicznych ustroju. Otyłość zwiększa ryzyko rozwoju cukrzycy typu 2, miażdżycy, chorób sercowo-naczyniowych oraz nadciśnienia. W pracy przedstawiono charakterystykę stosunkowo nowo odkrytych i mało poznanych adipokin: omentyny i waspiny, którym przypisuje się korzystne działanie, chroniące przed rozwojem zaburzeń metabolicznych towarzyszących otyłości. Ponadto zwrócono uwagę na ich potencjalny udział w patogenezie łuszczycy oraz możliwość wykorzystania jako markerów nasilenia choroby oraz ryzyka rozwoju powikłań metabolicznych.

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Serum omentin-1 levels are inversely associated with the presence and severity of coronary artery disease in patients with metabolic syndrome

Abstract: Serum omentin-1 might be a potential biomarker to predict the development and progression of CAD in MetS patients.

Cited by 77 publications

References 17 publications

Association of omentin Val109Asp polymorphism with coronary artery disease

Association of omentin Val109Asp polymorphism with coronary artery disease

Omentin-1 levels in patients with premature coronary artery disease, metabolic syndrome and healthy controls. Short communication

Role of omentin and vaspin in metabolic diseases in association with psoriasis

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