Serum omentin levels predicts mesenteric ischemia

Abstract

Abstract:Background:Acute mesenteric ischemia (AMI) is an intestinal vascular disease with high mortality. Clinical diagnosis of acute mesenteric ischemia is diffi cult. Adipose tissue is an important mediator of metabolism and infl ammation.Omentin is produced by visceral adipose tissue and decreased serum levels of omentin are associated with poor metabolic outcomes. We aimed to investigate whether serum omentin level predicts early diagnosis of AMI before development of transmural ischemia. Methods: Twenty-four Sprague Dawley rats weighted about 200-250 gr grouped in 3 experimental groups as sham, transient ischemia and permanent ischemia. Each group consisted of 8 rats. Blood samples were evaluated to determine serum urea, creatinine, omentin and C-reactive protein (CRP) levels. A blinded histological examination performed with the same histologist for hemotoxileneosine painted ileal tissue samples. Results: Mean serum omentin level in sham group (27.5±4.67) was signifi cantly elevated compared to rats in Ischemia-reperfusion (IR) group (10.9±9.01).The difference reached the statistical signifi cance (p=0.004). Serum omentin levels were not correlated to urea, creatinine or CRPlevels. Conclusion:Omentin levels may be a biochemical indicator to detect AMI. However, further human studies are needed (Tab. 3, Fig. 3, Ref. 34). Text in PDF www.elis.sk.

Serum neuregulin 4 (NRG‐4) level and non‐alcoholic fatty liver disease (NAFLD): A case‐control study

“…6 For instance, omentin, cardiothrophin and neuregulins as adipocytokines are found to be correlated with various inflammatory, metabolic and impaired glucose tolerance conditions including mesenteric ischemia, diabetes, diabetic nephropathy, chronic kidney disease, pancreatitis and pregnancy. [7][8][9][10][11] Neuregulin 4 (NRG-4), a novel brown adipose tissue (BAT)-secreted adipokine, functions in an autocrine/paracrine or endocrine manner. 12 It has been demonstrated that NRG-4 exerts beneficial metabolic effects in mice.…”

Ibuprofen increases the serum Omentin levels in rats after abdominal surgery

“…Decreased levels of omentin in synovia have been reported in rheumatoid arthritis 6 , and reduced omentin messenger RNA expression has been reported in the omentum of subjects with Chrohn's disease 7 . Authors reported reduced omentin levels in acute appendicitis 8 and mesenteric ischemia settings 9 . On the other hand, the effects of C-reactive protein and tumor necrosis factor-alpha on endothelial cells were reduced by omentin 10 .…”

The Efficiency of Serum Biomarkers in Predicting the Clinical Outcome of Patients with Mesenteric Ischemia during Follow-Up: A Systematic Review

“…This serum marker turns positive in 30 min. The study concluded that, for thromboembolism of the SMA, bowel ischemia of any other cause, and patients needing a laparotomy, the sensitivity and predictive value of a negative Ddimer test were 100% [48]. Additionally, in another study, with median levels of 1.6 mg/L, patients with AMI had significantly higher levels of D-dimer than patients in the control group [47].…”