Serum osteoprotegerin and carotid intima–media thickness in acute/chronic coronary artery diseases

Ciccone, Marco Matteo; Scicchitano, Pietro; Gesualdo, Michele; Zito, Annapaola; Carbonara, Roberta; Locorotondo, Manuela; Mandurino, Cosimo; Masi, Francesco; Boccalini, Francesca; Lepera, Mario Erminio

doi:10.2459/jcm.0b013e3283561433

Cited by 19 publications

(21 citation statements)

References 32 publications

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“…11 We also observed that OPG levels were significantly associated with both PWV and ccIMT in elderly diabetic and HD patients similar to Pateinakis et al, (2013) 12 who demonstrated an independent positive association of serum OPG with carotid IMT in 61 peritoneal dialysis patients.…”

Section: Discussion:-supporting

confidence: 88%

Study of Plasma Osteoprotegerin level and arterial stiffness in chronic kidney disease and hemodialysis patients.

Al-Barshomy¹,

Kamal²,

Sayed³

et al. 2016

IJAR

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Section: Discussion:-supporting

confidence: 88%

Study of Plasma Osteoprotegerin level and arterial stiffness in chronic kidney disease and hemodialysis patients.

Al-Barshomy¹,

Kamal²,

Sayed³

et al. 2016

IJAR

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“…are often observed in the emergency and cardiology departments. Due to the high amount of CVD, the need to early detect de-compensated conditions of individuals forced physicians to adopt tools and biochemical parameters able to detect the early sign of health instability.Biomarkers are the most important, immediate and easy tools adopted in order to detect the early signs of CVD and their acute expression [5][6][7][8][9]. Furthermore, their predictive value is fundamental in order to better evaluate the patients and their future cardiovascular risk.…”

mentioning

confidence: 99%

The Role of Biomarkers in the Emergency Cardiovascular Setting

Ciccone

Scicchitano²,

Gesualdo³

et al. 2014

Emergency Medicine

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Cardiovascular Diseases (CVD) are the major cause of death worldwide, accounting for an increasing prevalence of death which will reach 23.6 million of affected persons in the 2030, [1] and for an incidence varying from 3.9 per 1,000 person-years to 37.1 per 1,000 person-years according to the presence of cardiovascular risk factors [2].Such data are not limited to the Western countries' populations: emerging countries declare increasing CVD prevalence and incidence which are able to reduce the overall quality of life and lifespan of their inhabitants [3,4].The emergency department, in agreement with the cardiology department, is the place where all the acute aspects of CVD are gathered. Acute Coronary Syndromes (ACS) in the form of unstable angina, non-ST (NSTEMI) or ST (STEMI) segment elevation myocardial infarction, acute heart failure, pulmonary embolism, etc. are often observed in the emergency and cardiology departments. Due to the high amount of CVD, the need to early detect de-compensated conditions of individuals forced physicians to adopt tools and biochemical parameters able to detect the early sign of health instability.Biomarkers are the most important, immediate and easy tools adopted in order to detect the early signs of CVD and their acute expression [5][6][7][8][9]. Furthermore, their predictive value is fundamental in order to better evaluate the patients and their future cardiovascular risk.According to ACS conditions, troponins are the best biomarkers already established for the detection of such conditions [5,6]. Roy et al. which compared the most novel biomarkers (heart fatty acid binding protein [HFABP]-1 and copeptin and troponin) and the best troponins assays in 850 patients presenting at the emergency department for acute chest pain. According to the 68 patients who were admitted at the cardiology department with the diagnosis of myocardial infarction, the authors found an AUC ranging from 0.92 to 0.94 for troponins assays, which were data strongly higher than those coming from the AUC for HFABP-1 [0.84 (0.77 to 0.90)] or copeptin [0.62 (0.57 to 0.68)]. In particular, the novel high sensitive troponins I (hsTnI) assays demonstrate a sensibility for the detection of myocardial infarction equal to 97% (95% CI: 91-99%), specificity equal to 81% (95% CI: 76-86%), a positive predictive value equal to 63% (95% CI: 55-71%) and a negative predictive value equal to 99% (95% CI: 96-100%) [12]. Creatin kinase (CK) is another biomarker which helps physicians in the acute cardiovascular setting [5]. Chin et al. [13] recently demonstrated that both peak CK-MB and peak troponin I were independently related to the in-hospital mortality of a dataset of patients suffering from acute myocardial infarction and gathered in the National Cardiovascular Data Registry ACTION Registry-GWTG (Acute Coronary Treatment and Intervention Outcomes Network Registry-Get With The Guidelines). They observed that CK-MB were able to slightly increase the in-hospital mortality rate prediction of both STEMI (model C-statistic...

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“…Uma vez que a aterosclerose é uma doença sistêmica, a aterosclerose carotídea também pode refletir o desenvolvimento deste processo em artérias coronárias e vice-versa e a EMIC pode ser mais associada com a gravidade da SCA do que com a mortalidade (Demircan et al, 2005;Ciccone et al, 2013;Rosa et al, 2003). (Greenland et al, 2010).…”

Section: Emic Como Fator Preditor De Risco Cardiovascularunclassified

“…De acordo com os resultados deste estudo, foram reportados valores mais elevados de EMIC na SCA comparativamente ao grupo com DAC crônica (0,94 ± 0,22 vs. 0,86 ± 0,15 mm, P = 0,027) (Ciccone et al, 2013).…”

Section: Emic Como Fator Preditor De Risco Cardiovascularunclassified

“…Independentemente de diferenças na metodologia e características da amostra comparando estes estudos prévios (Held et al, 2001;Tello-Montoliu et al, 2007) com o nosso, sugere-se que não há nenhuma relação entre EMIC e mortalidade em pacientes pós-SCA. Algumas hipóteses que talvez justifiquem estes resultados nulos, incluindo aqueles apresentados no nosso estudo, deve ser devido a EMIC ser um melhor marcador de aterosclerose subclínica em estágios iniciais da doença coronariana e, portanto, é um preditor fraco de mortalidade neste grupo de pacientes, mesmo nos valores mais elevados em comparação com indivíduos com DAC mais estável (Demircan et al, 2005, Ciccone et al, 2013, Rosa et al, 2003.…”

Section: O Valor Prognóstico Da Emic Na Scaunclassified

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Valor prognóstico da espessura médio-intimal da artéria carótida na mortalidade de curto e longo prazo na estratégia de registro de síndrome coronariana aguda (ERICO)

Meireles¹

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Serum osteoprotegerin and carotid intima–media thickness in acute/chronic coronary artery diseases

Abstract: OPG levels are higher in chronic CAD patients. CCA-IMT confirmed its importance in predicting CAD, showing significantly higher values in the patients in the ACS group as compared with those in the chronic CAD group.

Cited by 19 publications

References 32 publications

Study of Plasma Osteoprotegerin level and arterial stiffness in chronic kidney disease and hemodialysis patients.

Study of Plasma Osteoprotegerin level and arterial stiffness in chronic kidney disease and hemodialysis patients.

The Role of Biomarkers in the Emergency Cardiovascular Setting

Valor prognóstico da espessura médio-intimal da artéria carótida na mortalidade de curto e longo prazo na estratégia de registro de síndrome coronariana aguda (ERICO)

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