Serum osteoprotegerin and tumor necrosis factor related apoptosis inducing-ligand (TRAIL) are elevated in type 2 diabetic patients with albuminuria and serum osteoprotegerin is independently associated with the severity of diabetic nephropathy

Chang, Yu‐Hung; Lin, Kun‐Der; He, Sin-Ru; Hsieh, Ming‐Chia; Hsiao, Jeng-Yueh; Shin, Shyi–Jang

doi:10.1016/j.metabol.2010.11.002

Cited by 42 publications

(30 citation statements)

References 22 publications

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“…This finding supports the growing concept that OPG may act as an important regulatory molecule in microangiopathy and, particularly, that it may be involved in the development of nephropathy in type 1 diabetes. Serum concentrations of OPG are also significantly elevated in patients with type 2 diabetes with microalbuminuria and macroalbuminuria as compared with normoalbuminuric patients [35]. Using multivariate stepwise regression analysis, serum OPG was found to be an independent factor associated with the severity of diabetic nephropathy.…”

Section: Osteoprotegerin In the Kidneymentioning

confidence: 88%

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The osteoprotegerin/tumor necrosis factor related apoptosis-inducing ligand axis in the kidney

Candido

2014

Current Opinion in Nephrology and Hypertension

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Section: Osteoprotegerin In the Kidneymentioning

confidence: 88%

“…Serum concentrations of TRAIL are significantly elevated in diabetic patients with microalbuminuria and macroalbuminuria when compared with normoalbuminuric patients [35]. In addition, serum TRAIL and OPG levels are increased in parallel and are significantly associated with each other.…”

Section: Trail In Diabetic Nephropathymentioning

confidence: 90%

The osteoprotegerin/tumor necrosis factor related apoptosis-inducing ligand axis in the kidney

Candido

2014

Current Opinion in Nephrology and Hypertension

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“…Also, in a study on diabetic people, a strong association was observed between circulating OPG and microvascular complications [4, 21, 31]. It is suggested that insulin resistance and inflammatory cytokines might mediate upregulation of the OPG release observed in humans and may reflect the endothelial dysfunction in subjects with diabetes [32].…”

Section: Discussionmentioning

confidence: 99%

SNP rs2073618 of the Osteoprotegerin Gene Is Associated with Diabetic Retinopathy in Slovenian Patients with Type 2 Diabetes

Ramuš¹,

Kumše²,

Petrovič

et al. 2013

BioMed Research International

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Recent studies indicate that osteoprotegerin (OPG) acts as an important regulatory molecule in the vasculature. Also, a strong association was observed between circulation OPG and microvascular complication. By considering the possible role of OPG in diabetic retinopathy (DR) we examined two of the most studied polymorphisms of the OPG genes rs2073618 (located in exon I) and rs3134069 (located in the promoter region) and their relation to DR in Slovenian patients with type 2 diabetes. Logistic regression analysis demonstrated that the carriers of the CC genotype had a 2.2 higher risk for DR than those with either the CG genotype or the GG genotype (codominant model for rs2073618). Furthermore, the combined effect of single nucleotide polymorphisms (SNPs) rs2073618 and rs3134069 on the DR was stronger than that of each SNP alone. The odds ratio (OR) for individuals with CC genotype (rs2073618) and AA genotype (rs3134069) compared with carriers of CG/GG (rs2073618) + AA (rs3134069) was 2.54 (95% CI = 1.26–5.13, P = 0.01). To conclude, these results indicate that SNPs in the OPG gene may be implicated in the pathogenesis of DR.

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“…Serum TRAIL levels were associated with carotid intima-media thickness in a subset of T2DM patients with macrovascular diseases (Kawano et al, 2011). In addition, the serum concentrations of TRAIL and osteoprotegerin, the endogenous decoy receptor of TRAIL, in T2DM patients with microalbuminuria and macroalbuminuria are significantly higher than those of patients with normoalbuminuria, and serum osteoprotegerin was identified to be an independent factor associated with the severity of diabetic nephropathy (Chang et al, 2011). In this study, we also detected higher levels of Scr in T2DM patients with the CC genotype, further indicating that patients with the CC genotype at SNP rs1131580 of TRAIL might have more severe T2DM than patients with the TT genotype.…”

Section: Discussionmentioning

confidence: 97%

Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 diabetes mellitus in a Han Chinese population

Yu¹,

Zhao²,

Yan³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is expressed in different tissues and cells, including the pancreas and lymphocytes, and it can selectively induce apoptosis in tumor cells but not in most normal cells. TRAIL plays critical roles in type 1 diabetes mellitus, and is involved in type 2 diabetes mellitus (T2DM). We recently discovered the association of nonalcoholic fatty liver disease, a risk factor for T2DM, with a single nucleotide polymorphism (SNP) in the TRAIL (TNFSF10) gene at site 1595C/T (rs1131580), indicating the possible association of T2DM with this TRAIL polymorphism. The aim of this study was to investigate the relationship of the TRAIL SNP at site 1595C/T (rs1131580) with T2DM susceptibility and the biometabolic parameters of T2DM in a Han Chinese population. The polymerase chain reaction-restriction fragment length polymorphism method was used to genotype SNP rs1131580 in 292 patients with T2DM and 266 healthy controls. We found that the frequency of the CC genotype and that of the C allele of rs1131580 were significantly higher in T2DM patients than in the control group. Additionally, the triglyceride and serum creatinine levels of T2DM patients with the CC genotype were significantly higher than those of patients with the TT genotype. Thus, the CC genotype of the TRAIL SNP at 1595C/T (rs1131580) confers increased susceptible to T2DM in a Han Chinese population from Shandong Province. These data suggest that the CC genotype at this SNP is related to diabetic severity and it might be a candidate for the prognostic assessment of T2DM.

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Serum osteoprotegerin and tumor necrosis factor related apoptosis inducing-ligand (TRAIL) are elevated in type 2 diabetic patients with albuminuria and serum osteoprotegerin is independently associated with the severity of diabetic nephropathy

Cited by 42 publications

References 22 publications

The osteoprotegerin/tumor necrosis factor related apoptosis-inducing ligand axis in the kidney

The osteoprotegerin/tumor necrosis factor related apoptosis-inducing ligand axis in the kidney

SNP rs2073618 of the Osteoprotegerin Gene Is Associated with Diabetic Retinopathy in Slovenian Patients with Type 2 Diabetes

Association between the TRAIL single nucleotide polymorphism rs1131580 and type 2 diabetes mellitus in a Han Chinese population

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