Serum Osteoprotegerin is Associated with Arterial Stiffness Assessed According to the Cardio-ankle Vascular Index in Hypertensive Patients

Lee, Chung‐Jen; Wang, Ji‐Hung; Chen, Mei‐Ling; Yang, Chiu-Fen; Chen, Yu‐Chih; Hsu, Bang‐Gee

doi:10.5551/jat.25882

Cited by 27 publications

(22 citation statements)

References 36 publications

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“…Body mass index was calculated as the weight in kilogram divided by the height in meter square [101112]. Bio- impedance measurements of fat mass were performed at the bedside according to the standard tetrapolar whole-body (hand- foot) technique, using a single-frequency (50 kHz) analyzer (Biodynamic-450, Biodynamics Corporation, Seattle, WA, USA).…”

Section: Methodsmentioning

confidence: 99%

“…5 mL collected) of approximately 0.5 mL for hemoglobin and white blood cell counts (Sysmex K-1000, Sysmex American, Mundelein, IL, USA) were immediately centrifuged at 3000g for 10 minutes. Serum levels of blood urea nitrogen (BUN), creatinine (Cre), fasting glucose, total cholesterol, triglycerides (TGs), high-density lipoprotein-choles- terol, low-density lipoprotein-cholesterol, total calcium, and phosphorus were measured using an autoanalyzer (cobas integra 800, Roche Diagnostics, Basel, Switzerland) [101112]. Serum OPG levels (eBioscience Inc., San Diego, CA, USA) were measured using a commercially available enzyme-linked immunosorbent assay (ELISA) [101112].…”

Section: Methodsmentioning

confidence: 99%

“…The inter- and intra-assay coefficients of variation for OPG were 8.0% and 7.0%, respectively. The participants’ serum intact parathyroid hormone (iPTH; Diagnostic Systems Laboratories, Webster, TX, USA) levels were measured using a commercially available ELISA [101112]. The equation from the Modification of Diet in Renal Disease was used to calculate the estimated glomerular filtration rate in this study.…”

Section: Methodsmentioning

confidence: 99%

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Serum osteoprotegerin levels associated with the aortic augmentation index in renal transplant recipients

Hsu

Lee

Chen

et al. 2016

Tzu Chi Medical Journal

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Objectives:Arterial stiffness is recognized as an independent risk factor for cardiovascular morbidity and mortality. Recent studies found that osteoprotegerin (OPG) is associated with arterial stiffness and may reflect endothelial dysfunction. The aim of this study was to evaluate the relationship between fasting serum OPG levels and the aortic augmentation index (AIx) in renal transplant recipients.Materials and methods:Fasting blood samples were obtained from 66 renal transplant recipients. The aortic AIx was measured using a validated tonometry system (SphygmoCor). Serum OPG levels were measured using a commercial enzyme-linked immunosorbent assay kit.Results:Univariate linear analysis of the aortic AIx in renal transplant recipients revealed that body fat mass (r = 0.377, p = 0.002), aortic diastolic blood pressure (DBP; r = 0.307, p = 0.020), triglycerides (r = 0.260, p = 0.035), and logarithmically transformed OPG (log-OPG, r = 0.402, p < 0.001) were positively correlated, whereas height (r = 0.361, p = 0.004) and body weight (r = 0.212, p = 0.041) were negatively correlated with the aortic AIx in renal transplant recipients. Multivariate forward stepwise linear regression analysis of the factors significantly associated with the aortic AIx showed that log-OPG (R2 = 0.213, p < 0.001), height (R2 = 0.081, p = 0.009), and aortic DBP (R2 = 0.058, p = 0.022) were independent predictors of the aortic AIx in renal transplant recipients.Conclusion:These results suggest that the serum fasting OPG level is associated with the aortic AIx in renal transplant recipients.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Serum osteoprotegerin levels associated with the aortic augmentation index in renal transplant recipients

Hsu

Lee

Chen

et al. 2016

Tzu Chi Medical Journal

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“…Some data suggested that OPG may be important for endothelial cells survival and protection from VC [36,38]. OPG production is strengthened by BMPs, ROS, inflammatory mediators, estrogens and vitamin D. However, elevated level of OPG was found in patients with CVD, suggesting its abnormal high serum concentration in vivo may be associated with endothelial dysfunction and arterial calcification [39,40].…”

Section: Role Of Bone Biologymentioning

confidence: 96%

Osteoporosis and cardiovascular disease: an update

Lello

Capozzi

Scambia

2015

Gynecological Endocrinology

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Osteoporosis (OP) and cardiovascular diseases (CVD) are the most important causes of mortality and morbility in the elderly. Lots of studies showed a correlation between bone loss and cardiovascular risk mediated by the vascular calcification. The relationship between OP and CVD could be firstly explained by their common risk factors such as age, smoking, alcohol consumption, physical activity and menopause. However, other different hypotheses were proposed to clarify this link. Multiple factors, for example bone morphogenetic proteins, osteoprotegerin, receptor activator of nuclear factor κB ligand, parathyroid hormone, phosphate, oxidized lipids and vitamins D and K seemed to be involved in both conditions, indicating a possible common pathophysiologic mechanism. We review and discuss the available data describing this association. Further studies are necessary to better investigate similarities between OP and CVD.

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“…Pulse wave velocity (PWV) is an indicator of arterial stiffness [2,3], and a marker of vascular damage [4][5][6]. Thus, in the review of 2013 Korean Society of Hypertension guidelines for the management of hypertension, PWV was also advanced as a method of detecting subclinical organ damage [7].…”

Section: Introductionmentioning

confidence: 99%

A genome-wide association study of the association between single nucleotide polymorphisms and brachial-ankle pulse wave velocity in healthy Koreans

Shin

Lim

et al. 2017

J Genet Med

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Purpose: Pulse wave velocity (PWV) is an indicator of arterial stiffness, and is considered a marker of vascular damage. However, a genome-wide association study analyzing single nucleotide polymorphisms (SNPs) associated with brachial-ankle PWV (baPWV) has not been conducted in healthy populations. We performed this study to identify SNPs associated with baPWV in healthy populations in Korea. Materials and Methods: Genomic SNPs data for 2,407 individuals from three sites were analyzed as part of the Korean Genomic Epidemiologic Study. Without replication samples, we performed multivariable analysis as a post hoc analysis to verify the findings in site adjusted analysis. Healthy subjects aged between 40 and 70 years without self-reported history or diagnosis of hypertension, diabetes, hyperlipidemia, heart disease, cerebrovascular disease and cancer were included. We excluded subjects with a creatinine level >1.4 mg/dL (men) and 1.2 mg/dL (women). Results: In the site-adjusted association analysis, significant associations (P<5×10 -8 ) with baPWV were detected for only 5 SNPs with low minor allele frequency. In multivariable analysis adjusted by age, sex, height, body mass index, mean arterial pressure, site, smoking, alcohol, and exercise, 11 SNPs were found to be associated (P<5×10 ) linked to three genes (OPCML, PRR35 and RAB40C) were common between site-adjusted analysis and multivariable analysis. However, meta-analysis of the result from three sites for the 11 SNPs showed no significant associations. Conclusion: Using the recent standard for genome-wide association study, we did not find any evidence of significant association signals with baPWV.

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Serum Osteoprotegerin is Associated with Arterial Stiffness Assessed According to the Cardio-ankle Vascular Index in Hypertensive Patients

Cited by 27 publications

References 36 publications

Serum osteoprotegerin levels associated with the aortic augmentation index in renal transplant recipients

Serum osteoprotegerin levels associated with the aortic augmentation index in renal transplant recipients

Osteoporosis and cardiovascular disease: an update

A genome-wide association study of the association between single nucleotide polymorphisms and brachial-ankle pulse wave velocity in healthy Koreans

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