Serum parameters and severity of coronary artery disease in patients with acute coronary syndrome

Abstract

Introduction: Coronary artery disease (CAD) is one of the most common causes of morbidity and mortality in developed countries. SYNTAX (SX) score is a useful index that scores lesion severity during coronary angiography (CA) and can predict the patient’s outcome. Recent studies have associated a number of serum parameters with SX score, including platelet volume, and platelet-to-lymphocyte ratio (PLR). Objectives: We aimed to study the SX score in association with various serum parameters to find a valuable parameter for prediction of CAD severity. Patients and Methods: This study consisted of 363 patients referred to Heshmat hospital (Rasht) from March 2016 to October 2016 with acute coronary syndrome (ACS). Serum laboratory parameters were measured after 12 hours of fasting. Severity of CAD was evaluated during CA by SX score. The associations were analyzed using multinomial logistic regression model. Results: The mean age of patients was 63.68±11.03 years; since 26.2% of cases had severe, 43% had moderate, and 30.8% had mild CAD. Comparing to mild CAD, the multivariate adjusted model showed higher significant odds of severe CAD for one elevation of platelets (odds ratio [OR] =2.18 (95% CI: 1.35-3.50), white blood cells (WBCs) (OR=1.66, 95% CI: 1.17-2.35) RDW (red cell distribution width), (OR=1.59, 95% CI: 1.08-2.35) and serum creatinine (OR=1.75, 95% CI: 1.16-2.63). Conclusion: Plasma platelets, WBC and RDW and also serum creatinine were all independently correlated with severity of CAD.

Role of Anemia and Leukocytosis as Severity Predictors of Coronary Artery Disease Stenosis : A Retrospective Cross-sectional Study

“…This Abduh, Muhammad Rizki Triono, Retno Widyastuti plaque in CAD or what is known as "stenosis" causes narrowing of the heart arteries. This narrowing of the heart arteries plays an important role in determining the prognosis and appropriate management for CAD patients (Mirbolouk et al, 2020). The severity of stenosis in CAD can be influenced by several contributing factors.…”

“…Other tests have also been reported to have a similar role. Simple blood tests such as hemoglobin (anemia) and leukocyte count (leukocytosis) are reported to predict the severity of CAD (Mirbolouk et al, 2020). This simple blood test has advantages compared to other blood parameter tests because it does not require fasting preparation before sampling.…”

“…Increased systemic inflammation and immune system activity are one of the key mechanisms for the development of CAD severity (Dai et al, 2022). One simple marker of systemic inflammation is the number of leukocytes (Mirbolouk et al, 2020). Leukocytes are reported to have a vital function in the development of CAD (Moriya, 2019).…”

Untitled

“…Unmanaged changes in demographic structures have the potential to create cultural, sexual, family, etc. revolutions by affecting social, economic, and lifestyle phenomena, and these phenomena are directly determinants of variables affecting national security [11][12][13]. In the current situation, the security threats that will arise due to falling fertility rates and Iran's entry into the population crisis are very serious and it is necessary for the country's security experts and officials to work together with a group of demographers and demographers of all patterns to predict the interaction of population and security [14][15][16].…”

Untitled

“…One consequence of this is that the body no longer responds adequately to insulin. A new analysis in the German Diabetes Study (GDS) was conducted at the German Diabetes Center (DDZ) to examine differences between subtypes of diabetes in terms of inflammatory biomarkers [10][11][12]. Biomarkers are markers that are present in the blood or in tissues and other parts of the body and are measured to check for certain changes in the body, such as inflammation [13][14][15].…”