Serum paraoxonase 1 and 3 activities in benign and malignant diseases of the prostate and changes in levels following robotic-assisted laparoscopic radical prostatectomy

Abstract

Background/aim: This study aimed to examine serum paraoxonase 1 and 3 (PON1 and PON3) activities in benign and malignant diseases of the prostate, to determine lipid profile and malondialdehyde (MDA) levels, and to investigate changes in levels following robotic-assisted laparoscopic radical prostatectomy (RALRP).Materials and methods: A total of 137 patients, including a control group, were enrolled in the study and assigned into four groups. Group 1 (n = 33) consisted of patients previously undergoing RALRP with no recurrence, group 2 (n = 36) consisted of patients diagnosed with prostate cancer (PCa) and undergoing RALRP, and group 3 (n = 34) consisted of patients diagnosed with benign prostatic hyperplasia. The control group (n = 34) consisted of healthy individuals. Serum low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride, cholesterol, prostate-specific antigen (PSA), PON1, PON3, and MDA values were measured. In addition, group 2 MDA, PON1, PON3, and PON1/HDL levels were investigated preoperatively and at the first month postoperatively.Results: Significant changes were found in PON1, PON3, and MDA levels. PON1 and PON3 levels decreased significantly in patients with PCa, while MDA levels increased. PON1 and PON3 increased postoperatively in the PCa group, while MDA decreased. BPH group PON1, PON3, and MDA levels were higher than those of the control group. Conclusion:An increase in free oxygen radicals in the body or a decrease in endogenous antioxidant enzyme levels can result in malignant and benign diseases of the prostate. Surgical excision of malignant tissue in PCa causes a decrease in oxidative stress.

Serum Paraoxonase-1 Activity and the Risk of Prostate Cancer Recurrence in Patients Treated with Radiotherapy

“…Several studies have also reported decreased serum PON1 activity in cancer patients [ 14 ]. While Bedir et al observed lower levels of PON1 in patients diagnosed with PCa, but before treatment, than in healthy population, the exact mechanism involved in the decrease in PON1 activity in PCa patients is still unclear [ 26 ]. In our study, we did not observe such a difference between PCa patients before treatment and the control group.…”

8-Hydroxy-2-Deoxyguanosine and 8-Iso-Prostaglandin F2α: Putative Biomarkers to assess Oxidative Stress Damage Following Robot-Assisted Radical Prostatectomy (RARP)

“…The finding of normal levels of the markers of oxidative stress in patients three months after successful RARP suggests that surgical excision of the prostate was associated with the removal of a key source of an excess of free radicals. Despite the fact that the biomarkers studied in the present report lack tissue specificity [ 40 ], these data argue that 8-OHdG and 8-Iso-PGF2α measurements in urine can help to predict radicality (and maybe local recurrence) following PCa surgery. In this study, we used a highly specific and sensitive validated LC–MS/MS method to detect changes in oxidative stress markers in urine samples.…”

Immune-Related Gene-Based Novel Subtypes to Establish a Model Predicting the Risk of Prostate Cancer

“…PRRG3 is a protein-coding gene, but to the best of our knowledge, no research has explored its role in cancer. Bedİr et al (2020) found that the PON3 level decreased significantly in patients with PCa. They also found that PON3 increased postoperatively in those with PCa.…”

“…They also found that PON3 increased postoperatively in those with PCa. They proposed that surgical excision of malignant tissue in PCa caused a decrease in oxidative stress and that a higher level of PON3 was associated with lower oxidative stress (Bedİr et al, 2020). Finally, IGSF1 is a novel oncogene regulating the progression of thyroid cancer (Guan et al, 2019); however, no study describing its role in PCa has been reported.…”