Serum paraoxonase 1 (PON1) measurement: an update

Cerón, José J.; Tecles, Fernando; Tvarijonaviciute, Asta

doi:10.1186/1746-6148-10-74

Cited by 153 publications

(96 citation statements)

References 68 publications

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“…PON-1 is synthesized in the liver and it is a Ca-dependent and HDL associated enzyme [40] . PON-1 decreases the oxidative stress in transgenic mice [41] , and there is an increase in the gene expressions related with oxidative stress in PON-1-knockout mice.…”

Section: Discussionmentioning

confidence: 99%

Türk Saanen Keçilerinde Geçiş Dönemi Boyunca Metabolik Parametreler ve Paraoksonaz-1 Değişiminin İncelenmesi

Baştan¹,

Salar²,

Baştan³

et al. 2017

Kafkas Univ Vet Fak Derg

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The aim of this study was to evaluate the metabolic changes and PON-1 levels in Turkish Saanen goats during the transition period. In the study, 60 Turkish Saanen goats were used and blood samples were taken from the jugular vein on days -30, -15, 0, +15, and +30 from parturition. In order to monitor metabolic profile changes, alkaline phosphatase (ALP), cholesterol (CHO), glucose (GLU), calcium (CA), phosphorus (PHO), total protein (TOP), triglyceride (TG), paraoxonase-1 (PON-1), β-hydroxybutyric acid (BHBA) and non-esterified fatty acid (NEFA) levels were determined. Serum alkaline phosphatase levels were lower on days -30, 0 and +15, and higher on day +30 (P<0.001). Serum cholesterol and total protein levels were lower on days -30 and 0, and higher on day +30 (P<0.001). Serum levels of glucose, calcium and phosphorus were lower on day 0, and higher on day +30 (P<0.001). Serum triglyceride levels were lower on days -15 and 0, and higher on days -30 and +30 (P<0.05). Serum paraoxonase-1 levels were lower on day 0, and higher on day -30 (P<0.05). Serum β-hydroxybutyric acid levels were lower on day -30, and higher on day +15 (P<0.05). Serum non-esterified fatty acid levels were lower on days -30 and +30, and were higher on days -15 and 0 (P<0.001). In conclusion, the results of our study showed that clear changes in levels of metabolic parameters and PON-1 were seen during the transition period in Turkish Saanen goats.

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Section: Discussionmentioning

confidence: 99%

Türk Saanen Keçilerinde Geçiş Dönemi Boyunca Metabolik Parametreler ve Paraoksonaz-1 Değişiminin İncelenmesi

Baştan¹,

Salar²,

Baştan³

et al. 2017

Kafkas Univ Vet Fak Derg

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“…It is able to control inflammation and protect cells from oxidative stress (Farid and Horil 2012) because it inhibits LDL oxidation. Ceron et al (2014) commented on its antibacterial effect against P. aeruginosa. Experimental studies have indicated that ARE plays an important role in the fight against bacterial biofilm formation (Camps et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Haematological and acute-phase response of dogs with experimental skin Pseudomonas aeruginosa infection to treatment with antibiotic and parthenolide

et al. 2016

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Changes in white blood cells, leukogram patterns, the positive acute-phase protein (APP) fibrinogen and negative APPs (albumin and arylesterase) were monitored to evaluate their potential as sensitive indicators throughout the course of therapy in canine skin Pseudomonas aeruginosa infection. The study was performed on 15 male mixed-breed dogs, divided in three groups of 5 dogs each. Dogs from group A were injected subcutaneously with P. aeruginosa bacterial culture (1 × 10 8 CFU/mL) at a dose of 0.3 mL/kg and treated with enrofloxacin (5 mg/kg, s.c.) on post infection hour 48 for 10 consecutive days. Dogs from group B were infected and treated with a combination of enrofloxacin (at abovementioned dose and intervals) and parthenolide (feverfew extract 90 mg, 0.7 % parthenolide). The schedule consisted of daily oral intake of two capsules of feverfew beginning on post infection hour 4 and continued for 6 days. The control group C included healthy dogs, injected s.c. with 0.3 mL/kg physiological saline. The haematological indices and APPs were assayed before infection and on 4th, 24th, 48th and 72nd hours and on 7th, 10th and 14th days after infection. Infected and antibiotic-treated dogs responded with significant leukocytosis, left shift, eosinopaenia and lymphopaenia between hours 24 and 72. In this group, fibrinogen increased substantially by post infection hours 24 (p < 0.01 vs 0 h; p < 0.05 vs group C), 48 (p < 0.001 vs 0 h; p < 0.05 vs group C) and 72 (p < 0.001 vs 0 h; p < 0.01 vs group C) while albumin reduction was marked by hours 48 (p < 0.05 vs 0 h) and 72 (p < 0.05 vs 0 h; p < 0.001 vs group C) and day 7 (p < 0.01 vs 0 h; p < 0.001 vs group C). The combination of enrofloxacin and parthenolide modified, at a significant extent, the deviations in studied parameters except for eosinophil percentage, which persisted low.

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“…Different substrates and assays were proposed for serum PON1 measurement, as a biomarker for diagnosis of diseases related with oxidative stress and inflammation, but there are still problems regarding the variety of substrates and the lack of reference methods [182,183].…”

Section: Paraoxonasesmentioning

confidence: 99%

Enzymatic Targets in Atherosclerosis

Fuior¹,

Trusca²,

Roman³

et al. 2015

J Mol Genet Med

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Atherosclerosis, a prime cause of mortality across the developed societies, was targeted by diverse therapeutic strategies. These evolved in response to the complex etiology and evolution of the disease. Many enzymes are associated with atherosclerosis, either in the main stream of lipid biosynthesis and transport or in the collateral and intertwined pathways of oxidative stress, inflammation, vascular remodeling or chromatin stability and are therefore revised herein. Enzyme exploration led to important developments. At the beginning, there were the statins, derived as inhibitors of hydroxy-methyl-glutaryl CoA (HMG-CoA) reductase, currently used widely to decrease lipid levels. At the other end, the inhibitors of the recently discovered proprotein convertase subtilisin/kexin type 9 (PCSK9) are awaiting the validation in clinical trials with great hopes for the future. In between, one can find some palliatives, as aspirin, an inhibitor of cyclooxygenase (COX), but also many invalidated candidates. Classical pharmacological data and newer approaches, like genetic knockouts in murine atherosclerosis models, are reviewed in order to appreciate the involvement of a particular enzyme in atherogenesis. However, the pursuit of an efficacious drug has been long and, in many cases, disappointing. Conclusions can be drawn from the overview of both successes and failures, in a quest for the best.

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Serum paraoxonase 1 (PON1) measurement: an update

Cited by 153 publications

References 68 publications

Türk Saanen Keçilerinde Geçiş Dönemi Boyunca Metabolik Parametreler ve Paraoksonaz-1 Değişiminin İncelenmesi

Türk Saanen Keçilerinde Geçiş Dönemi Boyunca Metabolik Parametreler ve Paraoksonaz-1 Değişiminin İncelenmesi

Haematological and acute-phase response of dogs with experimental skin Pseudomonas aeruginosa infection to treatment with antibiotic and parthenolide

Enzymatic Targets in Atherosclerosis

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