Serum pentraxin 3 as a biomarker for prognosis of acute minor stroke due to large artery atherosclerosis

Zhang, Yan; Hu, Hai‐Jie; Liu, Chong; Wu, Juan; Zhou, Shanshan; Zhao, Tingting

doi:10.1002/brb3.1956

Cited by 7 publications

(3 citation statements)

References 32 publications

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“…In general, those results are well-supported by another research. APCS , the member of the Pentraxin family, is involved in amyloidosis but it is also known to exert anti-inflammatory and antifibrotic properties (in particular, to inhibit monocyte differentiation into proinflammatory macrophages), thus could be used as inflammation and large artery atherosclerosis biomarker [ 58 ]. Similarly, the transgelin, acting via the transgelin–actin complex and modulating the reorganisation of the actin cytoskeleton, is known to participate in the regulation of the blood flows of coronary arteries, and thus is a promising therapeutic target for the treatment of myocardial ischemia [ 59 ].…”

Section: The Role Of Hsps In Cvdsmentioning

confidence: 99%

Heat Shock Protein 90 as Therapeutic Target for CVDs and Heart Ageing

Dabravolski

Sukhorukov

Kalmykov

et al. 2022

IJMS

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Cardiovascular diseases (CVDs) are the leading cause of death globally, representing approximately 32% of all deaths worldwide. Molecular chaperones are involved in heart protection against stresses and age-mediated accumulation of toxic misfolded proteins by regulation of the protein synthesis/degradation balance and refolding of misfolded proteins, thus supporting the high metabolic demand of the heart cells. Heat shock protein 90 (HSP90) is one of the main cardioprotective chaperones, represented by cytosolic HSP90a and HSP90b, mitochondrial TRAP1 and ER-localised Grp94 isoforms. Currently, the main way to study the functional role of HSPs is the application of HSP inhibitors, which could have a different way of action. In this review, we discussed the recently investigated role of HSP90 proteins in cardioprotection, atherosclerosis, CVDs development and the involvements of HSP90 clients in the activation of different molecular pathways and signalling mechanisms, related to heart ageing.

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Section: The Role Of Hsps In Cvdsmentioning

confidence: 99%

Heat Shock Protein 90 as Therapeutic Target for CVDs and Heart Ageing

Dabravolski

Sukhorukov

Kalmykov

et al. 2022

IJMS

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“… 5 , 6 For instance, previous extensive numerous studies had documented that patients with a poor prognosis after stroke had a significant increase in inflammatory markers including pentraxin 3, interleukin-18 (IL-18), interleukin-6, interleukin-8, and high-sensitivity C-reactive protein (hs-CRP). 7–9 Many studies have shown that higher levels of inducible nitric oxide synthase (iNOS), systemic immune-inflammation index, macrophage inflammatory protein 1α (MIP-1α), and hs-CRP are positively associated with increased risk for PSD. 10–12 In another study, IL-18 has also been shown to be correlated with PSD and plays an important role in the development of depression-like behaviors through the IL-18 receptor/NKCC1 signaling pathway.…”

Section: Introductionmentioning

confidence: 99%

Elevated Red Blood Cell Distribution Width Levels at Admission Predicts Depression After Acute Ischemic Stroke: A 3-Month Follow-Up Study

Li¹,

Zhang²,

Dong³

et al. 2022

NDT

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Purpose Red blood cell distribution width (RDW) is closely related to inflammatory-related disease markers. The present study aimed to investigate the association between the red blood cell distribution width (RDW) and post-stroke depression (PSD). Patients and Methods A total of 414 patients with acute ischemic stroke (AIS) admitted to our hospital from June 2018 to July 2021 were consecutively enrolled and received 3 months’ follow-up. According to the 17-item Hamilton Depression Scale (HAMD) assessment, they were divided into PSD group and non-PSD group. Diagnosis of PSD was made in accordance with DSM-IV. RDW was recorded within 24 hours of admission. Results Among the included 414 patients, 95 (22.95%) patients were diagnosed as having PSD at 3 months after stroke. The results showed significantly higher level of RDW in patients with depression (13.69 (IQR13.24–13.88) vs. 13.56 (IQR 12.67–13.77), P<0.001) at admission than patients without depression. After adjustment for potential confounding factors, the odds ratio of PSD was 5.707 (95% CI, 2.717–11.989) for the highest tertile of RDW compared with the lowest tertile. Moreover, based on the receiver operating characteristic (ROC) curve, the optimal cutoff of RDW levels as an indicator for the prediction of PSD was projected as 13.01, which yielded a sensitivity of 83% and a specificity of 41.0%, with an area under the curve (AUC) of 0.643 (95% CI, 0.585–0.701; P = 0.012). Conclusion Higher RDW levels at admission were found to be correlated with PSD 3 months after stroke.

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“…PTX3 has attracted interest in relation to vascular pathology and pregnancy complications [10][11][12][13][14][15]. Elevated levels of PTX3 have been suggested to predict cardiovascular events, independently of other risk factors, such as increased CRP.…”

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confidence: 99%

Pentraxin‐3 detected in human saliva shows limited correlation with biomarkers associated with systemic inflammation

Wetterö

Jönsson

Löhneysen

et al. 2021

APMIS

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Pentraxin‐3 (PTX3) is a conserved protein of the innate immune system which has been less studied than the pentraxin C‐reactive protein (CRP), but it is of relevance in, for example, vascular pathology and pregnancy morbidities. Since the interest in salivary biomarkers in general is increasing, we asked whether PTX3 could be detected in saliva and if any substantial diurnal variation occurs. In addition, we evaluated association with biomarkers of systemic inflammation (interleukin (IL)‐1β, IL‐6, and IL‐8 and CRP), body mass index (BMI), smoking, and age. PTX3 in morning and evening saliva from 106 middle‐aged participants of the general population was investigated by ELISA and total protein levels by spectrophotometry. PTX3 was detectable in saliva, and concentrations varied over the day with higher morning concentrations, but the PTX3 relative protein levels (percentage of total protein) were significantly higher in the evening. Sex and age did not impact salivary PTX3, but smoking was associated with lower PTX3 levels. BMI correlated positively with PTX3 in evening saliva. There was no general association with biomarkers of systemic inflammation, except for IL‐6. Salivary PTX3 likely reflects the local inflammatory milieu, and adjustments for sampling time, smoking habits, and BMI are needed to adequately interpret PTX3 in saliva.

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Serum pentraxin 3 as a biomarker for prognosis of acute minor stroke due to large artery atherosclerosis

Cited by 7 publications

References 32 publications

Heat Shock Protein 90 as Therapeutic Target for CVDs and Heart Ageing

Heat Shock Protein 90 as Therapeutic Target for CVDs and Heart Ageing

Elevated Red Blood Cell Distribution Width Levels at Admission Predicts Depression After Acute Ischemic Stroke: A 3-Month Follow-Up Study

Pentraxin‐3 detected in human saliva shows limited correlation with biomarkers associated with systemic inflammation

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