Serum pepsinogen level and abomasal ulcerations in experimental abomasal displacement in sheep

Hajimohammadi, Ali; Badiei, Khalil; Mostaghni, K.; Pourjafar, Mehrdad

doi:10.17221/3016-vetmed

Cited by 6 publications

(6 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Foreign bodies in the rumen [23] might be due to the development of pica, which is associated with nutritional deficiency and poor management practices [24,25]. The histopathological lesions observed in different organs of the goats in this study suggest degenerative and inflammatory responses and are in general agreement with those reported by Tariq et al [25] and Hajimohammadi et al [26].…”

Section: Discussionsupporting

confidence: 90%

Etiopathological and hematobiochemical profiles in goats with gastrointestinal disorders

et al. 2021

View full text Add to dashboard Cite

Background and Aim: Gastrointestinal (GI) disorders in small ruminants limit production efficiency and productivity growth in the livestock sector, thereby directly preventing farmers from augmenting their income. This study aimed to provide detailed insight into the etiology, hematobiochemical parameters, and epidemiological risk factors of GI disorders in goats and to determine the pathology associated with the disorders. Materials and Methods: Over the period of 2018-2019, 500 goats in and around Bhubaneswar, Odisha, India, were screened for GI disorders based on clinical signs. Blood samples from the control (n=10) and treatment (n=25) groups were collected for both hematological and serum biochemical alterations. Fecal examinations (n=220) were conducted for parasitic, bacterial, and virological assessments. Detailed necropsy and histopathological evaluations were conducted on 27 goats. Results: The GI disorder prevalence rate and mortality rate among the 500 goats analyzed were 44.4% and 12.27%, respectively. Chi-square analysis showed a significantly higher occurrence of GI disorders among the goats that were between 6 months and 1.5 years old (58.72%), were of the Ganjam breed (45.49%), had a poor body condition (71.11%), and were housed with an earthen floor (55.22%). The most common etiological risk factor observed was parasitic infection (65.45%), followed by bacterial (18.18%) and mixed infection (9.54%). Blood analysis showed neutrophilia and eosinophilia in infected goats, in addition to anemia; significant decreases in total protein, globulin, albumin, and glucose levels; and significant increases in aspartate transaminase and alanine aminotransferase levels. The major histopathological findings were infiltration of mononuclear cells and desquamation of the intestinal and ruminal mucosa. Conclusion: Stakeholders should focus not only on parasitic infections and other important etiological risk factors for GI disorders in goats but also on proper farming management practices to help enhance the income of farmers. The hematobiochemical alterations and pathomorphological changes reported in this study can be used by field veterinarians as guidelines for clinical evaluation and disease severity assessment.

show abstract

Section: Discussionsupporting

confidence: 90%

Etiopathological and hematobiochemical profiles in goats with gastrointestinal disorders

et al. 2021

View full text Add to dashboard Cite

show abstract

“…These reports also support our results (Figure 2). Abomasal damage was not confirmed with necropsy in the present study but based on the previous studies in cattle (Hajimohammadi et al, 2010;Voros et al, 1984; Zadnik and Mesaric, 1999), the increase in plasma pepsinogen concentrations detected in this study may indicate the occurrence of abomasal damages in calves.…”

Section: Discussioncontrasting

confidence: 71%

“…High plasma pepsinogen concentrations are thought to be associated with vascular permeability in the abomasum, such as the melena group in this study, and any damage to the gastric mucosa allows the diffusion of hydrogen ions from the lumen to the mucosal tissues similarly to previous studies. The studies report that the diffusion of pepsin and pepsinogen to the mucosa causes injury to the gastric mucosa (Hajimohammadi et al, 2010;Voros et al, 1984;Zadnik and Mesaric, 1999). These reports also support our results (Figure 2).…”

Section: Discussionmentioning

confidence: 99%

Investigation of plasma pepsinogen level in calves with abomasal distention

Mamak

Yıldız

Gokce

et al. 2022

Veterinary Journal of Mehmet Akif Ersoy University

View full text Add to dashboard Cite

The aims of the present study was to determine whether or not abomasal damages occurs in calves with abdominal distention using by plasma pepsinogen levels and the positivity of the fecal occult blood test (FOBT). In the study, 30 calves with abdominal distention (distention group) and 15 clinically healthy calves (control group), aged between 1-90 days, were used. Collected plasma samples of all the calves were used to determine plasma pepsinogen levels, using bovine specific ELISA. Fresh stool samples were also taken from the rectum of all the calves and used to determine occult blood in the samples. In the study, melena and occult blood were detected in 11 and 19 of the stool samples, respectively. The plasma pepsinogen levels of calves with abdominal distention (18.06±7.78 ng/ml) were significatly high compared to those of control group (6.70±2.08 ng/ml), (p

show abstract

“…On the other hand, cows with abomasitis, LDA, RDA and abomasal ulcers have increased serum pepsinogen levels (Mesarič et al, 2002). Hajimohammadi et al (2010) confirmed that serum pepsinogen levels were significantly higher in LDA and RDA affected sheep (investigated as a model for cattle). In contrast, Ohwada et al (2002) proved that serum pepsinogen concentrations in LDA, RDA and AV cows were significantly decreased compared with healthy cows.…”

Section: Discussionsupporting

confidence: 68%

Diagnostic and prognostic significance of serum gastrin and pepsinogen in dairy cows with displaced abomasum

Khalphallah¹,

Elmeligy²,

Aamer³

et al. 2018

BJVM

View full text Add to dashboard Cite

The study aimed to describe the changes in clinical findings and serum levels of gastrin, pepsinogen and chloride (Cl) in dairy cattle with displacement of the abomasum (DA) from day 0 until day 30 after surgery and to evaluate their diagnostic and prognostic value in evaluation of the abomasal function. The study was conducted on DA cattle (n=25) belonging to dairy farms in Hokkaido area, Japan. Cows were examined and sampled at days 0 (surgery), 7 and 30. Based on blood β-hydroxybutyric acid (BHBA) at day 0, DA cows were classified into three categories; DA only (<1.2 mmol/L), DA with subclinical ketosis (DA SCK: 1.2-2.4 mmol/L) and DA with clinical ketosis (DA CK: ≥2.5 mmol/L). All DA groups had higher serum gastrin than their physiological reference values in cattle both before or after surgery. Serum gastrin was significantly increased (P<0.05) in DA and DA SCK groups particularly at day 30 vs day 0. Serum pepsinogen and chlorides were not remarkably changed in any of the three diseased groups compared to reference values. Serum pepsinogen showed no significant within-and inter-group changes. The surgery and the 30-day follow-up period were not sufficient to serum gastrin to return to its physiological levels. In conclusion, further future studies may be required to investigate serum gastrin levels change in DA cattle. A longer follow up period up to 45 day is suggested.

show abstract

Serum pepsinogen level and abomasal ulcerations in experimental abomasal displacement in sheep

Cited by 6 publications

References 17 publications

Etiopathological and hematobiochemical profiles in goats with gastrointestinal disorders

Etiopathological and hematobiochemical profiles in goats with gastrointestinal disorders

Investigation of plasma pepsinogen level in calves with abomasal distention

Diagnostic and prognostic significance of serum gastrin and pepsinogen in dairy cows with displaced abomasum

Contact Info

Product

Resources

About