Serum pepsinogen levels and their infl uencing factors: A population-based study in 6990 Chinese from North China

Sun, Liping

doi:10.3748/wjg.13.6562

Cited by 25 publications

(20 citation statements)

References 15 publications

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“…Overall, we had 69 eradicated and 6 non-eradicated patients based on both PGII levels (baseline and post-therapy). In agreement with other studies [30,31,32], the mean level of PGII after eradication therapy was significantly lower with respect to the baseline level in the Hp -eradicated subjects (p = 0.0001).…”

Section: Resultssupporting

confidence: 81%

“…Overall, the use of the Gastropanel kit in our experience confirms the importance of PGII dosage in monitoring Hp infection, while the results are not encouraging in the case of gastric atrophy, besides a minimum utility of the PGI/PGII ratio, in contrast to previous reports [30,31,32,43]. However, in our series, multiple evolutive lesions, such as intestinal metaplasia and gastric atrophy, were present in many cases, and some of these cases showed indicative gastropanel values.…”

Section: Discussioncontrasting

confidence: 54%

“…The Gastropanel kit should have identified a specific group of subjects with serum biomarker alterations that would identify potentially evolutive gastric mucosa lesions, such as gastric atrophy, as has been shown in other studies [30,31,32], in order to avoid invasive investigations such as upper digestive tract endoscopy and to propose a specific, close follow-up program.…”

Section: Discussionmentioning

confidence: 99%

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Gastric Cancer Surveillance in a High-Risk Population in Tuscany (Central Italy): Preliminary Results

Filomena¹,

Saieva

Lucchetti³

et al. 2011

Digestion

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Background/Aims: The surveillance of subjects at high risk for developing gastric cancer (GC) may represent an effective strategy for reducing specific morbidity and mortality. The aim of this study was to identify GC at its initial phase and to identify precancerous lesions in a group of GC high-risk subjects. Methods: We enrolled first-degree relatives of patients affected by GC who resided in a GC high-risk area (Tuscany, Central Italy). The study’s protocol included the collection of several individual measurements, including a blood sample for the determination of specific biomarkers, an upper digestive tract endoscopy with detailed gastric biopsies and Helicobacter pylori (Hp) treatment followed by a specific check. Results: We enrolled 167 subjects who were members of 128 different familial groups with GC history. We identified 1 case of initial-phase GC, 1 gastric dysplasia type II, 32 intestinal metaplasia, 10 gastric atrophy, and 21 atrophic chronic gastritis. 81 subjects were Hp-positive and underwent eradication therapy. Conclusion: This study of a GC high-risk Italian population reveals positive results in terms of population compliance, the identification of specific gastric lesions requiring close follow-up and successful therapy for Hp infection. To define future surveillance strategies, a longer follow-up of these patients is necessary.

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Section: Resultssupporting

confidence: 81%

Section: Discussioncontrasting

confidence: 54%

Section: Discussionmentioning

confidence: 99%

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Gastric Cancer Surveillance in a High-Risk Population in Tuscany (Central Italy): Preliminary Results

Filomena¹,

Saieva

Lucchetti³

et al. 2011

Digestion

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“…Miki et al used serum PGA < 50 mg/L and PGA/PGC ratio <3.0 in a comprehensive screen of GC in Japan [36]. Sun et al reported that a PGA/PGC ratio <7 is suitable for identifying populations at high risk of GC in Chinese [37]. Tu et al evaluated temporal changes in PGA and PGC levels and PGA/PGC ratio with the risk for progression of gastric precancerous lesions and suggested that increased serum PGA and PGC and decreased PGA/PGC ratio were associated with risk for progression of gastric precancerous lesions [38].…”

Section: Pgc Expression and Cancermentioning

confidence: 99%

Pepsinogen C expression, regulation and its relationship with cancer

Shen¹,

Jiang

Yuan

2017

Cancer Cell Int

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Pepsinogen C (PGC) belongs to the aspartic protease family and is secreted by gastric chief cells. PGC could be activated to pepsin C and digests polypeptides and amino acids, but as a zymogen PGC’s functions is unclear. In normal physiological conditions, PGC is initially detected in the late embryonic stage and is mainly expressed in gastric mucosa. The in situ expression of PGC in gastric mucosa is decreased considerably in the process of superficial gastritis → atrophic gastritis → gastric cancer (GC), proving that PGC is a comparatively ideal negative marker of GC. Serum PGC, and PGA levels and the PGA/PGC ratio have satisfactory sensitivity, specificity and price–quality ratio for predicting high GC risk. Ectopic PGC expression is significantly increased in prostate cancer, breast cancer, ovary cancer and endometrial cancer. In those sex-related cancers high level PGC expression indicates better prognosis and longer survival. The regulation of PGC expression involves genetic and epigenetic alteration of the encoding PGC gene, hormones modulation and interactions between PGC with other transcription factors and protein kinases. More and more research evidence hinted that PGC has strong correlation with cancer. In the systematic review, we respectively elaborate the structure, potential physiological functions, expression characteristics and regulation of PGC, and especially focus on the relationship between PGC expression and cancer to highlight the role of PGC in the tumorigenesis and its application value in clinical practice.

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“…The detailed method of examination of serum pepsinogens has been described in our previous study [14]. Approximately 5 ml fasting blood was collected from each participant.…”

Section: Methodsmentioning

confidence: 99%

Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease

Sun

et al. 2013

BMC Clin Pathol

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BackgroundSerum pepsinogen (PG) I/II ratio has been widely used as “serological biopsy” for the screening of gastric cancer (GC) and atrophic gastritis (GA). However, study concerning in situ expression of PGs is currently insufficient, particularly for their relationship with serum PGs levels. This study was designed to investigate in situ expression of PGI and PGII in subjects with normal mucosa (NOR), superficial gastritis (GS), GA and GC, and to evaluate the correlations between PGs expressions in situ and in serum.Methods185 subjects were enrolled for the study, including 30 NOR, 70 GS, 54 GA and 31 GC. PGI and PGII expressions in situ and in serum were detected by immunohistochemistry and enzyme-linked immunosorbent assay (ELISA) respectively. H. pylori immunoglobulin (Ig) G was also determined by ELISA.ResultsIn situ expressions of PGI, PGII and PGI/II ratio consistently decreased in sequence of NOR/GS- > GA- > GC. The expressions of PGI, PGII and PGI/II ratio in situ were statistically higher in youngers than in olders (P < 0.05). In the NOR subjects, PGI staining was statistically higher in males than that in females (p = 0.02). For the correlations between in situ and serum expressions of PGI, PGII and PGI/II ratio, a borderline correlation in the total study sample (r = 0.131, P = 0.076) and a statistical correlation in GA cases (r = 0.307, P = 0.027) were observed for the PGI/II ratio. The PGI expression correlated well with that of PGII in situ and in serum.ConclusionsThe in situ levels of PGI, PGII and PGI/II ratio sharply decreased in the GA and GC cases. The youngers exhibited higher levels of PGI, PGII and PGI/II ratios than the olders. The in situ PGI/II ratio rather than PGI and PGII alone showed certain correlation with that in serum, and the PGI expression correlated well with PGII expression. Further studies with large-scale samples are still required to validate our findings.

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Serum pepsinogen levels and their infl uencing factors: A population-based study in 6990 Chinese from North China

Cited by 25 publications

References 15 publications

Gastric Cancer Surveillance in a High-Risk Population in Tuscany (Central Italy): Preliminary Results

Gastric Cancer Surveillance in a High-Risk Population in Tuscany (Central Italy): Preliminary Results

Pepsinogen C expression, regulation and its relationship with cancer

Pepsinogen I and II expressions in situ and their correlations with serum pesignogen levels in gastric cancer and its precancerous disease

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