Serum Pepsinogens, Gastrin-17 and <i>Helicobacter pylori</i> Antibody in the Residents of Two Cities in China with Distinct Mortality Rates of Gastric Cancer

Abstract

Gastric cancer is one of the most common malignant tumors causing death in Fujian Province, China. However, the mortality of gastric cancer is greatly varied in different areas in Fujian; for example, the mortality in Changle City is 7.4 times higher than that in Fuan City. In this study, we compared the differences in serological parameters, pepsinogen (PG) I, PG II, gastrin-17 (G-17), and Helicobacter pylori (H. pylori) antibody, between the two cities. It has been reported that low serum PG I is correlated with atrophic gastritis, a high-risk condition for developing gastric cancer, while high serum G-17 has been used for serological detection of atrophic corpus gastritis. We recruited 224 healthy subjects in Changle and 229 healthy subjects in Fuan, matched in age and sex. The serum levels of PG II and G-17 were significantly higher in Changle than those in Fuan. Importantly, the frequency of the subjects with low serum PG I (< 25 μg/L) was significantly higher in Changle than in Fuan, although the serum PG I levels were similar between the two cities. Moreover, the percentage of the subjects with high serum G-17 (≥ 2 pmol/L) and the positive rate of serum IgG antibody against H. pylori were significantly higher in Changle than those in Fuan. The detected differences in these serological parameters are consistent with the notion that the prevalence of atrophic gastritis may be higher in Changle than in Fuan, which results in a higher risk condition for developing gastric cancer in Changle.

Prevalence of atrophic gastritis in southwest China and predictive strength of serum gastrin-17: A cross-sectional study (SIGES)

“…Therefore, it can be inferred that the efforts in health education, screening and control of H. pylori in Sichuan province during the past decade makes the H. pylori-associated atrophic gastritis decreased. A study in two cities of Fujian province indicated the higher prevalence of H. pylori and atrophic gastritis might result in a higher risk condition for developing gastric cancer and a greater population mortality rate 31 . Therefore, these evidence based on Chinese population validated the value of massive screening of atrophic gastritis for the sake of gastric cancer control in China.…”

ZNF139 promotes tumor metastasis by increasing migration and invasion in human gastric cancer cells

“…Gastric cancer is the most common digestive carcinoma in China, and the mortality rate is among the highest in a variety of malignant tumors, seriously threatening the life and health of the people [12,13]. Because of gastric occult onset and strong migration and invasion ability of tumor cells, frequently there has been a regional lymph node metastasis or distant metastasis before treatment, leading to poor comprehensive treatment effects by surgery, radiotherapy and chemotherapy.…”

Using machine‐learning algorithms to identify patients at high risk of upper gastrointestinal lesions for endoscopy

“…Serological tests. Given their relevance to UGI lesions, [23][24][25][26][27] serum pepsinogen I (PG I), pepsinogen II (PG II), gastrin-17 (G-17), and Hp antibody (HpAb) were measured using enzyme-linked immunosorbent assays (BIOHIT Plc, Helsinki, Finland) according to the manufacturer's protocols. Samples that yielded questionable values were re-tested.…”