Serum perfluoroalkyl substances (PFAS) and risk of asthma and various allergies in adolescents. The Tromsø study Fit Futures in Northern Norway

Averina, Maria; Brox, Jan; Huber, Sandra; Furberg, Anne‐Sofie; Sørensen, Martin V.

doi:10.1016/j.envres.2018.11.005

Cited by 58 publications

(33 citation statements)

References 55 publications

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“…Exposure of PFOS is associated with risk of asthma prevalence 7 , 60 , 61 ; both animal model and in vitro cell model have indicated PFOS is involved in exacerbation of allergic asthma 10 , 62 . Herein, we further investigated if AIM2 inflammasome could mediate the PFOS-induced asthmatic exacerbation.…”

Section: Resultsmentioning

confidence: 99%

Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome

et al. 2021

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Perfluoroalkyl substances (PFAS) are widely used in various manufacturing processes. Accumulation of these chemicals has adverse effects on human health, including inflammation in multiple organs, yet how PFAS are sensed by host cells, and how tissue inflammation eventually incurs, is still unclear. Here, we show that the double-stranded DNA receptor AIM2 is able to recognize perfluorooctane sulfonate (PFOS), a common form of PFAS, to trigger IL-1β secretion and pyroptosis. Mechanistically, PFOS activates the AIM2 inflammasome in a process involving mitochondrial DNA release through the Ca2+-PKC-NF-κB/JNK-BAX/BAK axis. Accordingly, Aim2−/− mice have reduced PFOS-induced inflammation, as well as tissue damage in the lungs, livers, and kidneys in both their basic condition and in an asthmatic exacerbation model. Our results thus suggest a function of AIM2 in PFOS-mediated tissue inflammation, and identify AIM2 as a major pattern recognition receptor in response to the environmental organic pollutants.

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Section: Resultsmentioning

confidence: 99%

Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome

et al. 2021

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“…In a cohort of 675 Norwegian adolescents, aged 13–19 years, Averina et al. () examined both cross‐sectionally and prospectively the association between concentrations (medians) of the sum of 18 PFASs (11 ng/mL), PFOA (2 ng/mL), PFOS (6.5 ng/mL) and PFHxS (1 ng/mL) and asthma and allergies. Outcome assessments were based on both self‐report and clinical examinations.…”

Section: Appendix J – Human Observationsmentioning

confidence: 99%

Risk to human health related to the presence of perfluoroalkyl substances in food

Schrenk¹,

Bignami²,

Bodin³

et al. 2020

EFS2

333

265

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The European Commission asked EFSA for a scientific evaluation on the risks to human health related to the presence of perfluoroalkyl substances ( PFAS s) in food. Based on several similar effects in animals, toxicokinetics and observed concentrations in human blood, the CONTAM Panel decided to perform the assessment for the sum of four PFAS s: PFOA , PFNA , PFH xS and PFOS . These made up half of the lower bound ( LB ) exposure to those PFAS s with available occurrence data, the remaining contribution being primarily from PFAS s with short half‐lives. Equal potencies were assumed for the four PFAS s included in the assessment. The mean LB exposure in adolescents and adult age groups ranged from 3 to 22, the 95th percentile from 9 to 70 ng/kg body weight (bw) per week. Toddlers and ‘other children’ showed a twofold higher exposure. Upper bound exposure was 4‐ to 49‐fold higher than LB levels, but the latter were considered more reliable. ‘Fish meat’, ‘Fruit and fruit products’ and ‘Eggs and egg products’ contributed most to the exposure. Based on available studies in animals and humans, effects on the immune system were considered the most critical for the risk assessment. From a human study, a lowest BMDL 10 of 17.5 ng/ mL for the sum of the four PFAS s in serum was identified for 1‐year‐old children. Using PBPK modelling, this serum level of 17.5 ng/ mL in children was estimated to correspond to long‐term maternal exposure of 0.63 ng/kg bw per day. Since accumulation over time is important, a tolerable weekly intake ( TWI ) of 4.4 ng/kg bw per week was established. This TWI also protects against other potential adverse effects observed in humans. Based on the estimated LB exposure, but also reported serum levels, the CONTAM Panel concluded that parts of the European population exceed this TWI , which is of concern.

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“…In a similar age group (ages 10-15 years), Dong et al (2013) found children with increased exposure to PFOS, PFOA, PFBS, PFDA, PFDoA, PFHxS, and PFNA had an increased risk of asthma. Similarly, Averina et al (2019) studied older adolescents PFAS levels and risk of asthma.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Perfluoroalkyl substances exposure and immunity, allergic response, infection, and asthma in children: review of epidemiologic studies

Holst¹,

Nayak²,

Dembek

et al. 2021

Heliyon

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Serum perfluoroalkyl substances (PFAS) and risk of asthma and various allergies in adolescents. The Tromsø study Fit Futures in Northern Norway

Cited by 58 publications

References 55 publications

Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome

Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome

Risk to human health related to the presence of perfluoroalkyl substances in food

Perfluoroalkyl substances exposure and immunity, allergic response, infection, and asthma in children: review of epidemiologic studies

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