Serum persistent organic pollutants (POPs) and prostate cancer risk: A case-cohort study

Lim, Ji-Young; Nam, Chung Mo; Yang, Ji-Yeon; Rha, Koon Ho; Lim, Kyung Min; Jee, Sun Ha

doi:10.1016/j.ijheh.2017.03.014

Cited by 43 publications

(39 citation statements)

References 33 publications

(30 reference statements)

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“…POPs were largely used in the industry, and, despite the ban on their use by the Stockholm Convention on Persistent Organic Pollutants in 2001, they can still be released into the environment mainly owing to the industrial emission or incineration of municipal and industrial waste (Esposito et al, ; Hung, Katsoyiannis, & Guardans, ; Trivedi & Majumdar, ). The World Health Organization (WHO) raised awareness about POP impact on environment and human health, thus encouraging several studies, which demonstrated the association of the exposure to these compounds with cancer development, reproductive problems, neurobehavioral disorders, abnormalities in fetal development, immune alteration, and disruption of hormones (Darras, ; Gregoraszczuk & Ptak, ; Hardell, Bavel, Lindstrom, Eriksson, & Carlberg, ; Lim et al, ; Tran & Miyake, ).…”

Section: Introductionmentioning

confidence: 99%

“…So, overall, increasing evidence has demonstrated that metals can act as carcinogens through different mechanisms. encouraging several studies, which demonstrated the association of the exposure to these compounds with cancer development, reproductive problems, neurobehavioral disorders, abnormalities in fetal development, immune alteration, and disruption of hormones (Darras, 2008;Gregoraszczuk & Ptak, 2013;Hardell, Bavel, Lindstrom, Eriksson, & Carlberg, 2006;Lim et al, 2017;Tran & Miyake, 2017).…”

Section: Introductionmentioning

confidence: 99%

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Blood screening for heavy metals and organic pollutants in cancer patients exposed to toxic waste in southern Italy: A pilot study

Forte

Indovina

Costa

et al. 2019

Journal Cellular Physiology

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In Italy, in the eastern area of the Campania region, the illegal dumping and burning of waste have been documented, which could potentially affect the local population's health. In particular, toxic waste exposure has been suggested to associate with increased cancer development/mortality in these areas, although a causal link has not yet been established. In this pilot study, we evaluated blood levels of toxic heavy metals and persistent organic pollutants (POPs) in 95 patients with different cancer types residing in this area and in 27 healthy individuals. While we did not find any significant correlation between the blood levels of POPs and the provenance of the patients, we did observe high blood concentrations of heavy metals in some municipalities, including Giugliano, where many illegal waste disposal sites have previously been documented. Our results showed that patients with different cancer types from Giugliano had higher blood levels of heavy metals than healthy controls. Despite the obvious limitations of this exploratory study, our preliminary observations encourage further research assessing the possible association between exposure to hazardous waste, increased blood metals, and increased risk of cancer.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Blood screening for heavy metals and organic pollutants in cancer patients exposed to toxic waste in southern Italy: A pilot study

Forte

Indovina

Costa

et al. 2019

Journal Cellular Physiology

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“…who.int/foodsafety/areas_work/chemical-risks/pops/ en/). POPs have been implicated in human health problems including cancer, 1,2 birth defects, 3,4 immune system disorders, 5 endocrine disruption, 6 and reproductive disorder. 7 Recently, laboratory studies on animals and human epidemiological studies have identified associations between POP exposure and the potential for increased risk of metabolic disorder, obesity, and/or diabetes.…”

Section: Introductionmentioning

confidence: 99%

Metabolic impact of persistent organic pollutants on gut microbiota

et al. 2020

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“…Regarding DDT behavior, an epidemiological study revealed that an analysis performed by separating different contaminants allowed to detect specific associations of compound-effect; however, any possible effect related to the mixture could be unrecognized (20). In a case-cohort study, PCBs, along with OCPs, were evaluated, revealing that PCBs were associated with PCa risk (125) and that long-term exposure to low-doses of the contaminant increased the risk in the normal population (126).…”

Section: Exposure During Prenatal and Postnatal Lifementioning

confidence: 99%

Breast and prostate glands affected by environmental substances (Review)

Bleak

Calaf

2021

Oncol Rep

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Environmental endocrine disruptor chemicals are substances that can alter the homeostasis of the endocrine system in living organisms. They can be released from several products used in daily activities. Once in the organism, they can disrupt the endocrine function by mimicking or blocking naturally occurring hormones due to their similar chemical structure. This endocrine disruption is the most important cause of the well-known hormone-associate types of cancer. Additionally, it is decisive to determine the susceptibility of each organ to these compounds. Therefore, the present review aimed to summarize the effect of different environmental substances such as bisphenol A, dichlorodiphenyltrichloroethane and polychlorinated biphenyls in both the mammary and the prostate tissues. These organs were chosen due to their association with the hormonal system and their common features in carcinogenic mechanisms. Outcomes derived from the present review may provide evidence that should be considered in future debates regarding the effects of endocrine disruptors on carcinogenesis.

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Serum persistent organic pollutants (POPs) and prostate cancer risk: A case-cohort study

Cited by 43 publications

References 33 publications

Blood screening for heavy metals and organic pollutants in cancer patients exposed to toxic waste in southern Italy: A pilot study

Blood screening for heavy metals and organic pollutants in cancer patients exposed to toxic waste in southern Italy: A pilot study

Metabolic impact of persistent organic pollutants on gut microbiota

Breast and prostate glands affected by environmental substances (Review)

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