Serum phosphorus levels predict clinical outcome in fulminant hepatic failure

Abstract

The aim of this pilot study was to evaluate the incidence of hypophosphatemia and its association with clinical outcome in fulminant hepatic failure (FHF) .

Meta-analysis of performance of Kings’s College Hospital Criteria in prediction of outcome in non-paracetamol-induced acute liver failure

“…The search strategy identified 1427 studies potentially relevant of which 138 were retrieved, and 17 studies [11,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] were found with enough information to go forward into a meta-analysis ( Fig. 1).…”

Role of Liver Transplantation in Acute Liver Failure

“…A serum phosphate level >1.2 mmol/L on day 2 or 3 following APAP overdose carries a sensitivity of 89% and a specificity of 100% for predicting poor outcome (Baquerizo et al, 2003;Chung et al, 2003;Schmidt et al, 2003). The level of Gc-globulin, a protein which is markedly reduced in the setting of tissue injury, has not been shown to reliably predict survival in those with APAP-induced ALF.…”

Hypophosphatemia and recovery of post-hepatectomy liver insufficiency

“…The meaning of HP in association with liver failure or morbidity remains controversial. While some small observational studies reported an association with increased post-operative morbidity (13,14), others observed no difference (15,16). However, as the liver contains 0.3% of phosphorus by weight (17), liver regeneration is also associated with considerable movement of phosphate into the hepatocytes (18,19).…”