Serum Plasminogen Activator Inhibitor‐1 and Tumor Necrosis Factor‐α Levels in Obesity and Periodontal Disease

Akman, Pelin Taşdelen; Fentoğlu, Özlem; Yılmaz, Gülin; Arpak, Nejat

doi:10.1902/jop.2011.110548

Cited by 25 publications

(21 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Platelets release TGF‐beta as a latent growth factor, requiring activation by factors such as thrombospondin‐1 and plasmin . Serum contains factors that control the activity of these enzymes, such as plasminogen activator inhibitor‐1 and factors that bind TGF‐beta . Involving these mechanisms, serum might inhibit the activation of TGF‐beta that is directly released by platelets.…”

Section: Discussionmentioning

confidence: 95%

Platelets increase while serum reduces the differentiation and activity of osteoclasts in vitro

Agis

Schröckmair

Skorianz

et al. 2013

Journal Orthopaedic Research

View full text Add to dashboard Cite

Platelets modulate formation of osteoclasts and osteoblasts, but research with different preparations of platelets remains inconclusive. Here, we assessed whether serum components modulate the effect of platelet preparations. In murine bone marrow cultures, osteoclastogenesis was investigated in the presence of platelet-released supernatant (PRS), serum containing PRS (SC-PRS), and serum. Osteoclastogenesis was quantified by the numbers of tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells, TRAP activity and resorption assays. Also human osteoclastogenesis assays were performed. Viability and proliferation were tested by MTT and 3 [H]thymidine incorporation assays, respectively. Osteoblastogenesis was assessed by histochemical staining for alkaline phosphatase-of murine bone marrow cultures and human MG63 cells. We found PRS to increase the number of TRAP þ multinucleated cells in the early phase and TRAP activity in the later phase of osteoclastogenesis. SC-PRS and serum decreased the number and activity of TRAP þ multinucleated cells. Both serum containing preparations reduced viability and proliferation of hematopoietic progenitors. PRS decreased the numbers of alkaline phosphatase-positive colonies while SC-PRS and serum increased osteoblastmarkers in MG63. Proliferation of MG63 was stimulated by all preparations. These results show that activated platelets support osteoclastogenesis, while platelet preparations that contain serum components decrease osteoclastogenesis and increase osteoblastogenesis in vitro, suggesting that serum components modulate the effects of platelets on osteoclastogenesis and osteoblastogenesis. ß

show abstract

Section: Discussionmentioning

confidence: 95%

Platelets increase while serum reduces the differentiation and activity of osteoclasts in vitro

Agis

Schröckmair

Skorianz

et al. 2013

Journal Orthopaedic Research

View full text Add to dashboard Cite

show abstract

“…Both Bizzarro et al . and Akman et al . documented the importance of serum PAI‐1 as a marker in periodontal disease, with PAI‐1 levels increasing with increases in inflammation and disease progression.…”

Section: Discussionmentioning

confidence: 99%

The effect of low‐level laser therapy as an adjunct to non‐surgical periodontal treatment on gingival crevicular fluid levels of transforming growth factor‐beta 1, tissue plasminogen activator and plasminogen activator inhibitor 1 in smoking and non‐smoking chronic periodontitis patients: A split‐mouth, randomized control study

Pamuk

Lütfioğlu

Aydoğdu

et al. 2017

J of Periodontal Research

View full text Add to dashboard Cite

show abstract

“…As the severity of periodontitis increases, there is a greater systemic inflammatory response . Previous studies showed that periodontitis leads to atherosclerosis through periodontal pathogens and their by‐products, or through the release of inflammatory mediators from periodontal tissue that induce endothelial dysfunction . Pathological studies of atherosclerotic plaques have identified the presence of periodontal pathogens …”

Section: Introductionmentioning

confidence: 99%

Correlation between the severity of periodontitis and coronary artery stenosis in a Chinese population

Yang

Feng

Ren

et al. 2013

Australian Dental Journal

View full text Add to dashboard Cite

Background: The aim of this study was to evaluate the relationship between the severity of periodontitis and the extent and degree of coronary artery stenosis in a Chinese population. Methods: Patients (n = 853) with coronary artery stenosis confirmed by coronary angiography were eligible to take part in the study. Only subjects that were ≥60 years old, had ≥50% stenosis in at least one coronary artery, and did not have diabetes or a history of smoking were included (n = 115). After periodontal examination, including bleeding index, probing depth calculus index, plaque index and periodontal attachment loss, four groups were defined based on the severity of periodontitis: no periodontitis/gingivitis (M0, n = 19); mild periodontitis (M1, n = 27); moderate periodontitis (M2, n = 31); and severe periodontitis (M3, n = 38). The extent and degree of coronary artery stenosis was obtained by calculating the Gensini score (GS). Results: The GS was significantly greater in the M3 group compared with the M0 group. Multiple linear regression analysis revealed that probing depth and plaque index were significantly correlated with the GS. Conclusions: The extent and severity of coronary artery stenosis in Chinese patients ≥60 years old is positively correlated with the severity of periodontitis.

show abstract

Serum Plasminogen Activator Inhibitor‐1 and Tumor Necrosis Factor‐α Levels in Obesity and Periodontal Disease

Abstract: Serum PAI-1 levels may play an important role in the association between periodontal disease and obesity.

Cited by 25 publications

References 43 publications

Platelets increase while serum reduces the differentiation and activity of osteoclasts in vitro

Platelets increase while serum reduces the differentiation and activity of osteoclasts in vitro

Correlation between the severity of periodontitis and coronary artery stenosis in a Chinese population

Contact Info

Product

Resources

About