Serum polyunsaturated fatty acid metabolites as useful tool for screening potential biomarker of colorectal cancer

Zhang, Lijian; Chen, Bin; Zhang, Junjie; Li, Jian; Yang, Qingjing; Zhong, Qisheng; Zhan, Song; Liu, Huwei; Cai, Chun

doi:10.1016/j.plefa.2017.04.003

Cited by 36 publications

(32 citation statements)

References 63 publications

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“…The most prevalent LA oxylipins in plasma/serum were 9-and 13-HODE, consistent with previous studies [27,28], and these were lower in HP rat serum. Higher levels of LA oxylipins in serum are associated with pain and Achilles tendinopathy [28,155], and lower levels of 13-HODE have been reported in colon and lung cancer [156,157].…”

Section: Discussionmentioning

confidence: 99%

“…Other LA derived oxylipins such as HODE and oxoODEs play roles in oxidative stress, vasodilation, proliferation and inflammation and in the pathogenesis of atherosclerosis [27,126,153,154]. Some LA derived oxylipins in serum are associated with pain and Achilles tendinopathy [28,155], and lower levels of 13-HODE have been reported in colon and lung cancer [156,157]. Oxylipins in liver and blood have been associated with a number of diseased liver conditions and other disorders [22][23][24][25][26][27][28], but these have not been examined in the context of HP diets.…”

Section: Oxylipins In Kidney Liver and Serummentioning

confidence: 99%

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Linoleic acid derived oxylipins are elevated in kidney and liver and reduced in serum in rats given a high-protein diet

Islam

Ravandi

Aukema

2018

The Journal of Nutritional Biochemistry

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High protein (HP) diets are often used as a means to reduce obesity, but their long-term effects remain unclear. In vitro studies suggest the involvement of a subset of oxylipins in the tissue response to HP diets. To examine the role of these bioactive lipids in vivo, normal adult male Sprague Dawley rats were provided isocaloric diets with LP (low protein, 8% protein by weight), NP (normal protein, 14%) or HP (50%) diets for 2 weeks, and targeted lipidomic analysis of oxylipins in kidney (cortex and medulla), liver and serum was performed by HPLC-MS/MS. The main group of oxylipins affected by the HP diet was the oxylipins derived from linoleic acid (LA), many of which were elevated in kidney (particularly the medulla) and liver, but reduced in serum of rats provided the HP compared to NP or LP diets. A smaller proportion of other n-6 fatty acid derived oxylipins were lower in kidney and higher in liver, and none were affected in serum, by HP feeding. Few n-3 oxylipins were affected by protein level. In liver only, the oxylipin product to substrate ratios of the soluble epoxide hydrolase enzyme were higher in LP fed rats. Differences between cortex and medulla oxylipins suggest relatively higher cortex activity of 5- and 8-lipoxygenase and cytochrome P450 hydroxylase, and higher medulla cyclooxygenase and 12- and 15-lipoxygenase activity. Further studies are needed to elucidate the physiological effects of the changes in these novel oxylipins in response to short-term dietary HP.

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Section: Discussionmentioning

confidence: 99%

Section: Oxylipins In Kidney Liver and Serummentioning

confidence: 99%

Linoleic acid derived oxylipins are elevated in kidney and liver and reduced in serum in rats given a high-protein diet

Islam

Ravandi

Aukema

2018

The Journal of Nutritional Biochemistry

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“…The content of oxylipins in serum from CRC patients is changed in comparison with healthy subjects (Zhang et al, 2017). Among oxylipins in CRC the arachidonic acid (20:4 n-6) derived eicosanoids are the most well studied.…”

Section: Resultsmentioning

confidence: 99%

Oxylipins associated with colorectal cancer

Pakiet¹,

Stepnowski²,

Śledziński³

et al. 2018

Electrochemical Behavior and Determination of Ketoprofen at Glassy--Carbon Electrode

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“…They were incriminated in neuropathic pain, particularly concerning mechanical allodynia and thermal hyperalgesia 40 . In breast cancer, HODEs were the most important oxylipin species upregulated in plasma of cancer patients 41 whereas they were lowered in serum of colorectal cancer patients 42 . HODEs were widely described for their damaging effects on health but contradictory results are emerging from the literature.…”

Section: Discussionmentioning

confidence: 99%

Sciadonic acid derived from pine nuts as a food component to reduce plasma triglycerides by inhibiting the rat hepatic Δ9-desaturase

Pédrono

Boulier-Monthéan

Boissel

et al. 2020

Sci Rep

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Sciadonic acid (Scia) is a Δ5-olefinic fatty acid that is particularly abundant in edible pine seeds and that exhibits an unusual polymethylene-interrupted structure. Earlier studies suggested that Scia inhibited the in vitro expression and activity of the Stearoyl-CoA Desaturase 1 (SCD1), the hepatic Δ9-desaturase involved in the formation of mono-unsaturated fatty acids. To confirm this hypothesis, rats were given 10% Scia in diets balanced out with n-6 and n-3 fatty acids. In those animals receiving the Scia supplement, monoene synthesis in the liver was reduced, which was partly attributed to the inhibition of SCD1 expression. As a consequence, the presence of Scia induced a 50% decrease in triglycerides in blood plasma due to a reduced level of VLDL-secreted triglycerides from the liver. In non-fasting conditions, results showed that Scia-induced inhibition of SCD1 led to a decrease in the proportions of 16:1n-7 and 18:1n-7 in the liver without impacting on the level of 18:1n-9, suggesting that only triglycerides with neosynthesized monoenes are marked out for release. In conclusion, this in vivo study confirms that Scia highly inhibits SCD1 expression and activity. The work was performed on normotriglyceride rats over six weeks, suggesting promising effects on hyper-triglyceridemic models. Sciadonic acid (Scia) is composed of an aliphatic chain with 20 carbons and 3 unsaturations (20:3Δ5,11,14). It is a Δ5-olefinic acid, a fatty acid (FA) group characterized by the presence of a polymethylene-interrupted double bond at C5, as distinct from the more common malonic structure. In the natural environment, Scia is specifically abundant in conifers, although it is also present in trace amounts with different other olefinic structures in slime molds 1 and certain marine invertebrates 2. Seven Δ5-olefinic acids are commonly found in gymnosperms and their composition profile provides a good marker of the plant phylogeny 3,4. Scia is particularly associated with the suborder Taxares, representing up to 26% of the total FA content in Podocarpus nagi 5. It is ubiquitously found in pine nuts, constituting up to 7% of the total FA in Pinus pinaster 6. As it is present in edible seeds and consumed as a nutrient, studies performed on rodent models have been carried out to determine its functional effect. Scia is incorporated in membranes when supplied to the cells and substitutes for arachidonic acid (20:4n-6) in phospholipids such as phosphatidylinositol 7. Consequently, this unusual FA integrates lipid metabolism resulting in the modulation of physiological functions. Scia supplemented to mammal cells induces synthesis of the uncommon 16:2n-6 (Δ7,10), which is subsequently elongated into linoleic acid (18:2n-6 or Δ9,12) 8,9. Scia then reduces the production of modulators causing inflammation that are derived from arachidonic acid 10-13. In rats fed with a Scia-enriched diet, triglyceride levels are lowered in the blood plasma and the liver 14-16. Previous work performed in vitro on hepatocytes showed that Scia inhibited ...

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Serum polyunsaturated fatty acid metabolites as useful tool for screening potential biomarker of colorectal cancer

Cited by 36 publications

References 63 publications

Linoleic acid derived oxylipins are elevated in kidney and liver and reduced in serum in rats given a high-protein diet

Linoleic acid derived oxylipins are elevated in kidney and liver and reduced in serum in rats given a high-protein diet

Oxylipins associated with colorectal cancer

Sciadonic acid derived from pine nuts as a food component to reduce plasma triglycerides by inhibiting the rat hepatic Δ9-desaturase

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