Serum pro-inflammatory cytokines in physiological and pre-eclamptic pregnancies

Montagnana, Martina; Lippi, Giuseppe; Albiero, A.; Salvagno, Gian Luca; Franchi, Massimo Piergiuseppe; Guidi, Gian Cesare

doi:10.1080/09513590801895575

Cited by 30 publications

(19 citation statements)

References 15 publications

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“…In this study, we found that there was no significant change in the levels of IL1b in the serum of women with PE compared with normal pregnancy. There is a controversy about IL-1b in PE, while some authors reported increased blood serum levels compared with normal pregnant women [33], some were not able to detect a significant difference between the serum IL-1b levels of normal pregnant and preeclamptic women, similar to our study [34,35]. In summary, TNF-a and IL-1b were not found to be increased in preeclamptic pregnancies.…”

Section: Discussioncontrasting

confidence: 59%

“…There is a conflict on TNF-a level in PE in the literature. Although several studies have reported elevated circulating TNF-a in patients with PE [30][31][32][33], others failed to detect a correlation between TNFa and the later onset of PE [34,35]. Therefore, we investigated both macrophage activity and TNF-a and IL-1b cytokines in PE in relation to macrophages activity.…”

Section: Discussionmentioning

confidence: 94%

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Chitotriosidase, interleukin-1 beta and tumor necrosis factor alpha levels in mild preeclampsia

Alanbay

Çoksüer

Ercan

et al. 2011

Arch Gynecol Obstet

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Section: Discussioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 94%

Chitotriosidase, interleukin-1 beta and tumor necrosis factor alpha levels in mild preeclampsia

Alanbay

Çoksüer

Ercan

et al. 2011

Arch Gynecol Obstet

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“…Although small case-control studies have reported significant associations between various immune biomarkers and preeclampsia in the third trimester,[8, 11–17] these results have not been replicated in other investigations [18–23]. The most consistent associations have been found with IL-6, TNFα and IL-8.…”

Section: Introductionmentioning

confidence: 83%

Mid-pregnancy circulating immune biomarkers in women with preeclampsia and normotensive controls

Taylor

Tang

Ness

et al. 2016

Pregnancy Hypertension: An International Journal of Women's Car

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Objectives To determine if mid-pregnancy circulating immune biomarkers are associated with preeclampsia. Study Design Nested case-control study of 410 preeclamptic women and 297 normotensive controls with primiparous singleton pregnancies enrolled in the Danish National Birth Cohort. The mean gestational age in our cohort is 16 weeks (range 9–26). Main Outcome Measures Preeclampsia was defined by blood pressure ≥ 140/90mmHg and proteinuria ≥3g/24h. Serum immune biomarkers included interleukin (IL)-6, IL-6 receptor, IL-4, IL-4 receptor, IL-5, IL-12, IL-2, TNF-α, TNF-β, TNF-receptor, IL-1β, IL-1α, IL-8, IL-10, IFN-γ, IL-18, macrophage migration inhibitory factor, macrophage inflammatory protein, transforming growth factor-beta (TGF-β), and RANTES. Associations with preeclampsia, term preeclampsia and preterm preeclampsia were determined using two logistic regression models; 1) biomarkers were dichotomized by the limit of detection (LOD): 2) on the continuous scale, non-detectable values were imputed by LOD/2 and transformed (base 2). All models were adjusted for body mass index and smoking. Results IL1β was significantly associated with a decrease in the log odds of preeclampsia (p=0.0065), term preeclampsia (p=0.0230) and preterm preeclampsia (p=0.0068). Results were similar for IL4r and preeclampsia (p=0.0383). In the dichotomized models, detectable TNF-β was significantly associated with preeclampsia (ORadj 1.6, 95% CI 1.1–2.3) and term preeclampsia (ORadj 1.7, 95% CI 1.1–2.5) but not preterm preeclampsia. Detectable IL6 was significantly associated with term preeclampsia only (ORadj 1.5, 95% CI 1.1–2.2). Conclusion Mid-pregnancy circulating IL1β, IL4r, IL6, and TNFβ were associated with preeclampsia. However, results were not consistent across statistical models. As the relationship is complex, future studies should explore cytokine clusters in preeclampsia risk.

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“…On the contrary, others did not manage to identify a correlation between maternal serum levels of IL-6 or TNF-alpha and preeclampsia [19, 20]. Furthermore, Montagnana et al [29] based on their results concluded that preeclampsia screening based on cytokines such as IL-6 or TNF-alpha is not proposed.…”

Section: Discussionmentioning

confidence: 99%

Maternal Serum Levels of TNF-Alpha and IL-6 Long after Delivery in Preeclamptic and Normotensive Pregnant Women

Vitoratos

Economou

Iavazzo³

et al. 2010

Mediators of Inflammation

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Aim. To evaluate maternal TNF-alpha and IL-6 plasma levels in normotensive pregnant women, women with preeclampsia, and to examine the temporal changes in their levels from theantepartum to the postpartum period correlated with the regression of preeclampsia. Method. A prospective study was performed in the 2nd Department of Obstetrics and Gynecology, University of Athens. Blood samples were obtained: (1) antepartum at the time of clinical diagnosis of the syndrome, 2. 12-14 weeks postpartum. Results. No statistically significant differences were found in IL-6 levels, whereas a difference was found in TNF-alpha levels between preeclamptic and controls in antepartum period (0.80 pg/ml versus 0.60 pg/ml, P : .04). Long after delivery, TNF-alpha levels were significantly higher in preeclamptic compared to normotensive controls (0.86 pg/ml versus 0.60 pg/ml, P : .004). No difference was observed in TNF-alpha before and after delivery in both groups. No difference was noticed in IL-6 levels in women of normotensive group long after delivery compared to that before delivery. Long after delivery IL-6 levels were statistically significant higher in preeclamptic women compared to normal controls (3.53 ± 0.52 pg/ml versus 1.69 ± 0.48 pg/ml, P : .02). Conclusion. Preeclamptic women remain under a status of increased inflammatory stress up to 12-14 weeks postpartum despite the fact that all the other signs of preeclampsia are resolved.

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Serum pro-inflammatory cytokines in physiological and pre-eclamptic pregnancies

Abstract: Results of this study do not support standard screening for pro-inflammatory cytokines (TNF-alpha, IL-1, IL-6 and IFN-gamma) in pre-eclampsia.

Cited by 30 publications

References 15 publications

Chitotriosidase, interleukin-1 beta and tumor necrosis factor alpha levels in mild preeclampsia

Chitotriosidase, interleukin-1 beta and tumor necrosis factor alpha levels in mild preeclampsia

Mid-pregnancy circulating immune biomarkers in women with preeclampsia and normotensive controls

Maternal Serum Levels of TNF-Alpha and IL-6 Long after Delivery in Preeclamptic and Normotensive Pregnant Women

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