Serum Procalcitonin as an Index of Inhalation Injury in Burns

Nylen, Eric; O’Neill, William; Jordan, Marion H.; Snider, Richard H.; Moore, Charles F.; Lewis, Mark S.; Silva, O. L.; Becker, K. L.

doi:10.1055/s-2007-1003354

Cited by 126 publications

(51 citation statements)

References 11 publications

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“…140,146 Both BLPs and calcitonin have important functions in human lung pathophysiology. 13,147,148 Recent studies using baboons and genetically engineered mice have revealed a potential mechanistic link between BLPs derived from PNECs and chronic inflammatory lung disease. 13 BLPs are known to promote normal fetal lung development.…”

Section: Innervation and Chemoreception Function Of Pnecsmentioning

confidence: 99%

Functional facets of the pulmonary neuroendocrine system

Linnoila

2006

Laboratory Investigation

178

143

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Pulmonary neuroendocrine cells (PNECs) have been around for 60 years in the scientific literature, although phylogenetically they are ancient. Their traditionally ascribed functions include chemoreception and regulation of lung maturation and growth. There is recent evidence that neuroendocrine (NE) differentiation in the lung is regulated by genes and pathways that are conserved in the development of the nervous system from Drosophila to humans (such as achaete-scute homolog-1), or implicated in the carcinogenesis of the nervous or NE system (such as the retinoblastoma tumor suppressor gene). In addition, complex neural networks are in place to regulate chemosensory and other functions. Even solitary PNECs appear to be innervated. For the first time ever, we have mouse models for lung NE carcinomas, including the most common and virulent small cell lung carcinoma. Moreover, PNECs may be important for inflammatory responses, and pivotal for lung stem cell niches. These discoveries signify an exciting new era for PNECs and are likely to have therapeutic and diagnostic applications.

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Section: Innervation and Chemoreception Function Of Pnecsmentioning

confidence: 99%

Functional facets of the pulmonary neuroendocrine system

Linnoila

2006

Laboratory Investigation

178

143

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“…It is a stable protein ex vivo in plasma with a half-life of 24–29 h. It can routinely be used in laboratory examination of blood samples without any coling substitutes. The first reports from Assicot et al [6] and Nylen et al [7] demonstrate that calcitonin precursor molecules are found in patients with sepsis and bacterial inflammation.…”

Section: Introductionmentioning

confidence: 99%

Procalcitonin in Early Detection of Postoperative Complications

et al. 1998

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Background: A prospective clinical study was performed to assess the accuracy of procalcitonin in 70 patients with elective colorectal or aortal surgery and to compare it with inflammatory mediators. Also the early prediction of complications and the outcome of these patients was taken into account. Methods: Laboratory variables and cytokine determination were obtained preoperatively, on the day of operation and postoperatively on a daily basis from day 1 to 5, and on days 7 and 10 in the colorectal group and in the aortal surgery group at different times on the operation day after aortal clamping. The main outcome criteria were early recognition of complications and alterations in the production of procalcitonin and cytokines in order to detect severe infective complications. Results: Procalcitonin was closely related to postoperative complications with significantly elevated levels at day 1 after surgery. The plasma concentrations of IL-6 increase on days 1–3 without a difference in the groups, also C-reactive protein demonstrates no differences. Conclusion: Procalcitonin presents itself as a new parameter of infection and sepsis. In the postoperative period PCT seems to be an interesting marker of early prediction of infective complications when high postoperative levels are found. Under routine conditions procalcitonin is a valid reproducible and detectable parameter.

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“…Also, in the most severe inflammation of noninfectious aetiology, no PCT elevations could be observed, except in severe acute pancreatitis [14,15] and inhalation injuries in burns [16].…”

mentioning

confidence: 99%

Procalcitonin as a diagnostic tool in lower respiratory tract infections and tuberculosis

Polzin¹,

Pletz²,

Erbes³

et al. 2003

Eur Respir J

100

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The diagnostic significance of procalcitonin concentrations in lower respiratory tract infections and tuberculosis is not known. A prospective analysis was, therefore, performed in patients with acute exacerbation of chronic bronchitis (AECB), community-acquired pneumonia (CAP), hospital-acquired pneumonia (HAP) and tuberculosis and their procalcitonin levels compared with those of patients with noninfectious lung diseases (controls). In addition, standard inflammatory parameter data were collected.A prospective clinical study was performed with four different groups of patients and a control group that consisted of patients with noninfectious lung diseases. A total of 129 patients were included: 25 with HAP, 26 CAP, 26 AECB, 27 tuberculosis, and 25 controls. C-reactive protein level, blood cell counts and procalcitonin concentration were evaluated on the first day after onset of clinical and inflammatory symptoms prior to treatment.The median procalcitonin concentrations in HAP, CAP, AECB and tuberculosis were not elevated in relation to the cut-off level of 0.5 ng?mL -1 . In the HAP group, in four of five patients who subsequently died, procalcitonin concentrations ofw0.5 ng?mL -1 were found. In acute lower respiratory infections, such as HAP, CAP and AECB, significantly elevated levels were found in comparison to the control group, but below the usual cut-off level. No differences were observed between tuberculosis and the control group.Relative to the current cut-off level of 0.5 ng?mL -1 , procalcitonin concentration is not a useful parameter for diagnosis of lower respiratory tract infections. However, compared to the control group, there were significantly elevated levels in patients with hospital-acquired pneumonia, community-acquired pneumonia and acute exacerbation of chronic bronchitis below the current cut-off level, which should be further investigated. Eur Respir J 2003; 21: 939-943.

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Serum Procalcitonin as an Index of Inhalation Injury in Burns

Cited by 126 publications

References 11 publications

Functional facets of the pulmonary neuroendocrine system

Functional facets of the pulmonary neuroendocrine system

Procalcitonin in Early Detection of Postoperative Complications

Procalcitonin as a diagnostic tool in lower respiratory tract infections and tuberculosis

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