Serum Procalcitonin Correlates With Renal Function and Immune Components in Early-Stage Renal Transplant Recipients

Quan, Xin; Cheng, Feng; He, Jiacai; Fen, LI; Liao, Minxue; Wen, Jingyu; Wang, Xiaoxiao; Hou, Yifu; Yang, Hongji

doi:10.1016/j.transproceed.2021.01.032

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Fever, an abnormal leukocyte count, the length of ICU stay, and other PCT is an amino acid polypeptide precursor of calcitonin secreted by thyroid C cells and released during bacterial infection 4 ; it plays an essential role after the operation, similar to the traditional biomarkers of CRP and WBC counts. Unfortunately, these biomarkers were not significantly different between the two groups on the first day after LTx in our research and were thus unable to differentiate risk in the absence of recipient blood culture, which is the gold standard for diagnosing infection.…”

Section: Discussionmentioning

confidence: 99%

Infection evaluation in the early period after liver transplantation: A single‐center exploration

Jin

Chen

et al. 2023

Transplant Infectious Dis

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Background Infection is a significant risk factor that impacts for perioperative morbidity and mortality in liver transplantation (LTx) patients and is difficult to evaluate quantitatively in the early posttransplantation period. Thus, a biomarker to assess the risk of infection and the prognosis of the recipient is highly desirable. Methods A total of 128 consecutive patients with end‐stage liver diseases undergoing LTx between January 1, 2020 and December 31, 2021, at the First Affiliated Hospital of Zhejiang University School of Medicine, were screened retrospectively. Graft preservation fluid and blood samples were collected for culture, and other perioperative laboratory examination results were recorded, for assessment of infection status. Results After a follow‐up period of 30 days, the survival rate among the 128 LTx recipients was 94.5%. Multivariable regression analysis showed that the logarithmically transformed neutrophil‐to‐lymphocyte ratio (NLR) (HR = 3.548, 95% CI: ; p = .041) on post‐LTx day 1 and graft preservation fluid culture positivity (HR = 12.032, 95% CI: ; p = .006) were independent predictive factors for early prognosis after LTx. Conclusions Positive graft preservation fluid culture and the logarithmically transformed NLR on post‐LTx day 1 were independent predictive factors for early prognosis after LTx. The logarithmically transformed NLR could provide an earlier indication than culture results in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Infection evaluation in the early period after liver transplantation: A single‐center exploration

Jin

Chen

et al. 2023

Transplant Infectious Dis

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“…26 Moreover, PCT <0.5 and ≥0.5 have been associated with NLR. 27 Neutrophil extracellular traps (NET) are responsible for the role of neutrophil in the pathology of CKD and the increase of NLR. NET is a defense mechanism mediated by neutrophils, trapping bacterial pathogens by releasing DNA out of the cell compartment.…”

Section: Discussionmentioning

confidence: 99%

Correlation between Neutrophil-to-Lymphocyte Ratio (NLR) and Immature-to-total Neutrophil (I/T) Ratio to Bacterial Infection among Children with Chronic Kidney Disease

Puratmaja

Alam

Hakim

et al. 2022

AMJ

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Background: Chronic kidney disease (CKD) in children has a long-lived impact, such as an increased risk of bacterial infection. Infection may accelerate disease progression, making early detection crucial. Inflammatory markers typically used for bacterial infection are C-Reactive Protein (CRP) and Procalcitonin (PCT). This study aimed to determine the correlation between levels of neutrophil-to-lymphocyte ratio (NLR) and immature-to-total-neutrophil ratio (I/T ratio) to bacterial infection in children with CKD as indicated by the serum levels of CRP and PCT.Methods: Observational analysis with a cross-sectional design was conducted from January 2019 to November 2021 in children from 3 months to 18 years old with CKD and bacterial infection. Retrospective data were obtained from medical records at Dr. Hasan Sadikin General Hospital, Bandung. Correlation analysis was performed (SPSS program) at a 95% confidence level, and results were considered significant if the p-value <0.05.Results: There were 42 children, and 57% were female; with a median age of 13 years (range 1–17 years). Most patients had normal nutritional status (55%) although 40% were malnourished. Correlation analysis between I/T ratio and NLR with PCT was positive, with r=0.284 (p<0.05) and r=0.265 (p<0.05), respectively, whereas there was no significant correlation of I/T ratio (r=0,154; p>0.05) and NLR (r=0,188; p>0.05) to CRP.Conclusions: NLR and I/T ratios have a significant positive correlation with PCT levels but not with CRP levels. NRL and I/T ratios can be considered as alternative markers for diagnosing CKD in children with a bacterial infection.

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Predicting bacterial infection risk in patients with ANCA-associated vasculitis in southwest China: development of a new nomogram

Zhang

Sun

et al. 2022

Clin Rheumatol

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Serum Procalcitonin Correlates With Renal Function and Immune Components in Early-Stage Renal Transplant Recipients

Cited by 3 publications

References 16 publications

Infection evaluation in the early period after liver transplantation: A single‐center exploration

Infection evaluation in the early period after liver transplantation: A single‐center exploration

Correlation between Neutrophil-to-Lymphocyte Ratio (NLR) and Immature-to-total Neutrophil (I/T) Ratio to Bacterial Infection among Children with Chronic Kidney Disease

Predicting bacterial infection risk in patients with ANCA-associated vasculitis in southwest China: development of a new nomogram

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