Serum Procalcitonin for Discrimination of Blood Contamination from Bloodstream Infection due to Coagulase-Negative Staphylococci

Schuetz, Philipp; Müeller, Beat; Trampuž, Andrej

doi:10.1007/s15010-007-7065-0

Cited by 107 publications

(88 citation statements)

References 17 publications

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“…26 Furthermore, PCT may also be helpful in differentiating contamination from BSI due to coagulasenegative staphylococci, but this finding needs to be confirmed in larger studies. 27 Our results suggest that PCT levels can be used to enhance clinical judgment by helping clinicians predict BSIs. Blood cultures require 24 to 48 hours to provide meaningful information, but PCT results can be available within 1 hour, and decisions about admission and starting antibiotics can be made immediately thereafter.…”

Section: Original Article 5826mentioning

confidence: 73%

Can procalcitonin distinguish infectious fever from tumor‐related fever in non‐neutropenic cancer patients?

Shomali

Hachem

Chaftari

et al. 2012

Cancer

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BACKGROUND: Procalcitonin (PCT) has been proposed as a marker of infection and was studied in neutropenic patients. This study investigated its role in non‐neutropenic febrile cancer patients (NNCPs). METHODS: Between July 2009 and July 2010, a total of 248 NNCPs with fever were studied. PCT was measured in plasma within 24 hours of fever onset and 4 to 7 days thereafter, using a Kryptor system with a lower limit of quantitation of 0.075 ng/mL. Patients' clinical, microbiological, and radiological data were reviewed to make the diagnosis and were correlated with PCT levels. RESULTS: This study included 30 patients with bloodstream infection (BSI), 60 with localized bacterial infection, 141 with no documented infection, and 8 with tumor‐related fever. Most patients (98%) were inpatients or admitted to the hospital during the study. Patients with BSI had significantly higher PCT levels than did those with documented localized infections (P = .048) and no documented infection (P = .011). PCT levels were significantly higher in septic patients than in those without sepsis (P = .012). Patients with stage IV disease or metastasis had significantly higher baseline PCT levels than did those with early stages of cancer (P < .05). PCT levels dropped significantly in patients with bacterial infections in response to antibiotics (P < .0001). CONCLUSIONS: Baseline PCT levels are predictive of BSI and sepsis in NNCPs. They may be predictors of metastasis and advanced cancer. Subsequent decrease in PCT levels in response to antibiotics is suggestive of bacterial infection. Larger trials are needed to confirm the results of this pilot study. Cancer 2012. © 2012 American Cancer Society.

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Section: Original Article 5826mentioning

confidence: 73%

Can procalcitonin distinguish infectious fever from tumor‐related fever in non‐neutropenic cancer patients?

Shomali

Hachem

Chaftari

et al. 2012

Cancer

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“…Common to all observational studies is the difficulty to define the etiology with certainty. Potential advantages of PCT over CRP include a more rapid increase within 3-12 h and an earlier peak within 24 h [18][19][20]. Despite a longer half-life of PCT (22-35 h) [19] than CRP (19 h) [21], PCT levels decrease faster than CRP when the infection resolves [17].…”

Section: Specificity Challengesmentioning

confidence: 99%

“…Pathogens with low virulence such as Enterococcus faecium, Acinetobacter baumannii, or coagulase-negative staphylococci, which frequently cause nosocomial infections and elicit only little systemic inflammatory responses, are associated with smaller increases of PCT levels [20,52]. This has to be taken into account for decision-making and might explain the limited usefulness of PCT in patients with VAP [49].…”

Section: Pct In Bacteremic and Immunosuppressed Patientsmentioning

confidence: 99%

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Pros and cons of using biomarkers versus clinical decisions in start and stop decisions for antibiotics in the critical care setting

Albrich

Harbarth

2015

Intensive Care Med

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“…26 Hasil biakan dapat positif palsu karena terdapat kontaminasi. 27 Pendapat lain menyatakan bahwa infeksi adalah suatu sindrom klinis akibat proses bakteremi yang melibatkan berbagai organ dan bukan diagnosis akhir, oleh sebab itu sulit menentukan baku emas diagnosis infeksi atau sepsis. 28,29 Penilaian terhadap pengaruh faktor risiko maternal sebagai acuan untuk melakukan pemeriksaan lanjutan terhadap neonatus yang dicurigai mengalami infeksi awitan dini.…”

Section: Metodeunclassified

Leukositosis pada Ibu Sebagai Salah Satu Faktor Risiko Infeksi Neonatal Awitan Dini: Telaah Klinis di RSAB Harapan Kita

Hendrarto¹

2016

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Latar belakang. Infeksi awitan dini neonatal masih menjadi masalah karena tingginya angka kesakitan,kematian, biaya perawatan, dan akan menimbulkan komplikasi tumbuh kembang di kemudian harikhususnya bayi prematur. Di sisi lain diagnosis cepat sangat diperlukan terutama untuk menentukan saatpemberian antibiotik.Tujuan. Mengetahui hubungan faktor risiko maternal sebagai prediktor terjadinya infeksi neonatal awitandini (INAD).Metode. Studi kasus kontrol, retrospektif terhadap pasien neonatus yang dirawat di Unit Perawatan IntensifNeonatal, Rumah Sakit Anak dan Bunda ”Harapan Kita” sejak Desember 2008 sampai dengan November2010. Data dianalisis secara multivariat regresi logistik dengan menggunakan program SPSS 16.0.Hasil. Subyek penelitian 566 bayi baru lahir dari 5094 kelahiran selama periode dua tahun; ditemukan179 neonatus (35,17 per 1000 kelahiran) didiagnosis tersangka INAD, 12 (6,7%) terbukti berdasarkanpemeriksaan biakan darah. Jenis kuman adalah Staphylococcus epidermidis (6), candida sp (2), Staphylococcusaureus (1), Streptococcus B hemoliticus (1), Streptococcus maltophilia (1), serratia sp (1). Faktor risikoleukositosis (􀂕15.000 sel/mm3) pada ibu dan adanya leukosit (􀂕5/LPB) dalam cairan lambung bayi yangdiaspirasi segera setelah lahir memiliki probabilitas sebagai prediktor kemungkinan neonatus menderitainfeksi awitan dini sebesar 67.7%.Kesimpulan. Peningkatan jumlah leukosit darah ibu dan peningkatan jumlah leukosit dalam cairan lambungbayi yang diaspirasi segera setelah lahir merupakan prediktor kemungkinan neonatus menderita infeksiawitan dini

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Serum Procalcitonin for Discrimination of Blood Contamination from Bloodstream Infection due to Coagulase-Negative Staphylococci

Cited by 107 publications

References 17 publications

Can procalcitonin distinguish infectious fever from tumor‐related fever in non‐neutropenic cancer patients?

Can procalcitonin distinguish infectious fever from tumor‐related fever in non‐neutropenic cancer patients?

Pros and cons of using biomarkers versus clinical decisions in start and stop decisions for antibiotics in the critical care setting

Leukositosis pada Ibu Sebagai Salah Satu Faktor Risiko Infeksi Neonatal Awitan Dini: Telaah Klinis di RSAB Harapan Kita

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