Serum procalcitonin level and leukocyte antisedimentation rate as early predictors of respiratory dysfunction after oesophageal tumour resection

Bogár, Lajos; Molnár, Zsolt; Tarsoly, Piroska; Kenyeres, Péter; Márton, Sándor

doi:10.1186/cc4992

Cited by 15 publications

(6 citation statements)

References 14 publications

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“…Plasma PCT levels have been studied and compared with CRP in patients after major surgery and trauma, but the results are inconclusive. 14 – 18 , 20 So far, one study on post-esophagectomy showed a diagnostic value of PCT for development of sepsis 11 and another one for infectious complications. 13 We found an early diagnostic value of day 3 PCT levels for combined surgical/infectious complications presenting between days 3 and 10 independently from preoperative risk assessment scores, but not of infectious complications alone.…”

Section: Discussionmentioning

confidence: 99%

“… 6 , 8 – 10 , 12 , 13 PCT is an allegedly more specific marker of severe infection and complications after surgery than CRP, 14 – 16 but the literature is inconclusive in this respect. 17 , 18 So far, only five studies reported on PCT levels post-esophagectomy, 1 , 11 , 13 , 19 , 20 of which only two focused on post-operative infectious complications. 11 , 13 The latter studies suggested that PCT is useful for the diagnosis of infectious complications and discriminating sepsis from SIRS post-esophagectomy.…”

Section: Introductionmentioning

confidence: 99%

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Rising C-Reactive Protein and Procalcitonin Levels Precede Early Complications After Esophagectomy

Hoeboer

Groeneveld

Engels

et al. 2015

Journal of Gastrointestinal Surgery

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BackgroundElective esophagectomy with gastric tube reconstruction carries a high risk for complications. Early and accurate diagnosis could improve patient management. Increased C-reactive protein (CRP) levels may be associated with any, surgical or infectious, complication and procalcitonin (PCT) specifically with infectious complications.MethodsWe measured CRP and PCT on post-operative days 0, 1, 2, and 3 in 45 consecutive patients. Complications were recorded up to 10 days post-esophagectomy.ResultsTwenty-eight patients developed a post-operative complication (5 surgical, 14 infectious, 9 combined surgical/infectious, including anastomotic leakage), presenting on day 3 or later. Elevated days 2 and 3 and a rise in CRP preceded the diagnosis of general or combined surgical/infectious complications (minimum area under the receiver operating characteristics curve (AUROC) 0.75, P = 0.006). Elevated day 3 PCT preceded combined complications (AUROC 0.86, P < 0.001). High day 1 and 3 PCT levels preceded anastomotic leakage (minimum AUROC 0.76, P = 0.005), as did the day 3 CRP levels and their increases (minimum AUROC 0.78, P = 0.002).ConclusionsThis small study suggests that high or increasing CRP levels may precede the clinical diagnosis of general or surgical/infectious complications after esophagectomy. Elevated PCT levels may more specifically and timely precede combined surgical/infectious complications mainly associated with anastomotic leakage.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rising C-Reactive Protein and Procalcitonin Levels Precede Early Complications After Esophagectomy

Hoeboer

Groeneveld

Engels

et al. 2015

Journal of Gastrointestinal Surgery

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“…PCT is a specific marker of bacterial infection and has been reported as a predictor of postoperative infectious complications after esophagectomy [ 9 , 10 , 11 , 12 ]. We hypothesized that PCT is a predictor of infectious complications after esophagectomy, and of long-term prognosis.…”

Section: Introductionmentioning

confidence: 99%

Usefulness of Procalcitonin as a Predictor of Long-Term Prognosis in the Early Postoperative Period after Esophagectomy for Esophageal Cancer

Booka

Kikuchi

Haneda

et al. 2022

JCM

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The aim of this study was to investigate the relationship between serum procalcitonin (PCT) levels after esophagectomy and infectious complications and long-term prognosis. A total of 105 patients who underwent esophagectomy between 2012 and 2019 were stratified into two groups: PCT-High group of ≥1 ng/mL and PCT-Low group of <1 ng/mL. The clinical outcomes and prognostic factors were compared between the two groups 2 postoperative days (POD), 4 POD, and 7 POD after esophagectomy. As the postoperative days passed, the association between PCT and infectious complications became stronger, and the positive predictive value was 100% at 7 POD. At 2 POD, there was no significant association between PCT elevation and infectious complications. Patients in the PCT-Low group had significantly worse overall survival (OS) and recurrence-free survival (RFS) than those in the PCT-High group at 2 POD (p = 0.026 and p = 0.011, respectively). In multivariate analysis, advanced pathological stage (hazard ratio (HR), 5.348; 95% confidence interval (CI), 2.299–12.500; p < 0.001) and PCT-Low group at 2 POD (HR, 3.673; 95% CI, 1.116–12.092; p = 0.032) were also independent predictors of worse OS. PCT in the early postoperative period after esophagectomy could be a good predictor of prognosis.

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“…According to previous studies on blood biophysical properties including viscosity, [1][2][3][4][5][6] viscoelasticity, [7][8][9][10][11][12] deformability, [13][14][15][16][17][18] aggregation, [19][20][21][22] and erythrocyte sedimentation rate (ESR), [23][24][25][26][27] various cardiovascular diseases cause changes in the biophysical properties of the blood. The biophysical properties of the blood have been measured to effectively monitor disease states or their progresses.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic-based measurement of erythrocyte sedimentation rate for biophysical assessment of blood in an in vivo malaria-infected mouse

Kang

Lee

2014

Biomicrofluidics

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This study suggests a new erythrocyte sedimentation rate (ESR) measurement method for the biophysical assessment of blood by using a microfluidic device. For an effective ESR measurement, a disposable syringe filled with blood is turned upside down and aligned at 180 with respect to gravitational direction. When the blood sample is delivered into the microfluidic device from the top position of the syringe, the hematocrit of blood flowing in the microfluidic channel decreases because the red blood cell-depleted region is increased from the top region of the syringe. The variation of hematocrit is evaluated by consecutively capturing images and conducting digital image processing technique for 10 min. The dynamic variation of ESR is quantitatively evaluated using two representative parameters, namely, time constant (k) and ESR-area (A ESR ). To check the performance of the proposed method, blood samples with various ESR values are prepared by adding different concentrations of dextran solution. k and A ESR are quantitatively evaluated by using the proposed method and a conventional method, respectively. The proposed method can be used to measure ESR with superior reliability, compared with the conventional method. The proposed method can also be used to quantify ESR of blood collected from malaria-infected mouse under in vivo condition. To indirectly compare with the results obtained by the proposed method, the viscosity and velocity of the blood are measured using the microfluidic device. As a result, the biophysical properties, including ESR and viscosity of blood, are significantly influenced by the parasitemia level. These experimental demonstrations support the notion that the proposed method is capable of effectively monitoring the biophysical properties of blood. V C 2014 AIP Publishing LLC. [http://dx

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Serum procalcitonin level and leukocyte antisedimentation rate as early predictors of respiratory dysfunction after oesophageal tumour resection

Cited by 15 publications

References 14 publications

Rising C-Reactive Protein and Procalcitonin Levels Precede Early Complications After Esophagectomy

Rising C-Reactive Protein and Procalcitonin Levels Precede Early Complications After Esophagectomy

Usefulness of Procalcitonin as a Predictor of Long-Term Prognosis in the Early Postoperative Period after Esophagectomy for Esophageal Cancer

Microfluidic-based measurement of erythrocyte sedimentation rate for biophysical assessment of blood in an in vivo malaria-infected mouse

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