2023
DOI: 10.1371/journal.pone.0284520
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Serum procalcitonin level is independently associated with mechanical ventilation and case-fatality in hospitalized COVID-19-positive US veterans–A potential marker for disease severity

Abstract: The Coronavirus-19 disease (COVID-19) has claimed over 6.8 million lives since first being reported in late 2019. The virus that causes COVID-19 disease is highly contagious and spreads rapidly. To date, there are no approved prognostic tools that could predict why some patients develop severe or fatal disease outcomes. Early COVID-19 studies found an association between procalcitonin (PCT) and hospitalization or duration of mechanical ventilation and death but were limited by the cohort sizes. Therefore, this… Show more

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Cited by 3 publications
(3 citation statements)
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“…Some studies have found that elevated PCT levels are associated with the severity of infection, inflammatory response, and tissue damage in COVID-19 ( 33 35 ). Higher PCT levels may also indicate worsening infection and poor prognosis ( 36 , 37 ). In patients with COVID-19 infection or MI, the levels of CRP often increase ( 38 ).…”
Section: Discussionmentioning
confidence: 99%
“…Some studies have found that elevated PCT levels are associated with the severity of infection, inflammatory response, and tissue damage in COVID-19 ( 33 35 ). Higher PCT levels may also indicate worsening infection and poor prognosis ( 36 , 37 ). In patients with COVID-19 infection or MI, the levels of CRP often increase ( 38 ).…”
Section: Discussionmentioning
confidence: 99%
“…We reported that a serum PCT cut-off value of 1.2 ng/ml on admission and 0.44 ng/ml on day 5 of hospitalization predicted mortality with a sensitivity of 72.7% and 88.9% and a specificity of 78.6% and 85.7%, respectively. Jeyapalina et al [6] reported serum PCT greater than 0.20 ng/ml to be independently associated with mechanical ventilation and mortality in hospitalized COVID-19 patients (unadjusted HR, 2.28, 95%CI: 2.16-2.41 for mortality). In a meta-analysis that included patients of various severities (nonsevere and severe), the cut-off value that predicted mortality ranged from 0.05 to 0.5 ng/mL [17].…”
Section: Discussionmentioning
confidence: 99%
“…Several clinical and laboratory parameters have been used in patients infected with SARS-CoV-2, either individually or in the form of a risk-scoring system, to predict the severity of illness, disease progression, and mortality [4,5]. Various studies have evaluated the role of serum levels of pro-calcitonin (PCT) in predicting disease severity and mortality in such patients [6][7][8]. PCT synthesis is triggered by various toxins and cytokines like interleukin-6 (IL-6) or tumor necrosis factor-alpha (TNF-ɑ).…”
Section: Introductionmentioning
confidence: 99%