Serum progesterone screening for frozen embryo transfer: present and future
            perspectives

Coroleu, Buenaventura; Gaggiotti-Marre, Sofía

doi:10.5935/1518-0557.20190013

Cited by 2 publications

(2 citation statements)

References 7 publications

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“…Coroleu and Gaggiotti-Marre have speculated that a certain serum P value should be attained for an adequate immunological environment to allow implantation to occur and reduce pregnancy loss in FET cycles [ 11 ]; however, Polat et al, in a recent retrospective study, reported that neither the circulating P level nor the type of progesterone administration were independent predictors of ongoing pregnancy rate [ 12 ]. Therefore, based on existing research, the relationship between the serum progesterone levels on ET day and pregnancy outcomes as well as a certain dose of progesterone to achieve the most optimal clinical pregnancy and live birth rate are debatable topics.…”

Section: Introductionmentioning

confidence: 99%

Serum progesterone levels greater than 32.5 ng/ml on the day of embryo transfer are associated with lower live birth rate after artificial endometrial preparation: a prospective study

Alyasin

Aghahosseini

Kabiri-Nasab

et al. 2021

Reprod Biol Endocrinol

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Background Previous observational studies have highlighted the negative effects of serum hormone levels at the minimum threshold during frozen embryo transfer (FET) cycles. However, still the questions regarding the maximum threshold level, and the highest allowed dosage of hormonal medications remain unresolved. The present study was conducted to determine whether there is any relationship between the serum progesterone and estradiol levels on the day of ET, and live birth rate (LBR) in patients receiving HRT in FET cycles. Methods In this prospective cohort study, eligible women who were undergoing their first or second FET cycles with the top graded blastocyst stage embryos were included. All patients received the same HRT regimen. FET was scheduled 5 days after administration of the first dosage of progesterone. On the morning of ET, 4–6 h after the last dose of progesterone supplementation, the serum progesterone (P4, ng/ml) and estradiol (E2, pg/ml) levels were measured. Results Amongst the 258 eligible women that were evaluated, the overall LBR was 34.1 % (88/258). The serum P4 and E2 values were divided into four quartiles. The means of women’s age and BMI were similar between the four quartiles groups. Regarding both P4 and E2 values, it was found that the LBR was significantly lower in the highest quartile group (Q4) compared with the others, (P = 0.002 and P = 0.042, respectively). The analysis of the multivariable logistic regression showed that the serum level of P4 on ET day, was the only significant predictive variable for LBR. The ROC curve revealed a significant predictive value of serum P4 levels on the day of ET for LBR, with an AUC = 0.61 (95 % CI: 0.54–0.68, P = 0.002). The optimum level of serum P4, with 70 % sensitivity and 50 %specificity for LBR, was 32.5 ng/ml. Conclusions The present study suggests that a serum P4 value at the maximum threshold on the day of FET is associated with reduced LBR following blastocyst transfer. Therefore, measuring and monitoring of P4 levels during FET cycles might be necessary. However, the results regarding the necessity for the screening of serum E2 levels before ET, are still controversial, and further prospective studies are required.

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Section: Introductionmentioning

confidence: 99%

Serum progesterone levels greater than 32.5 ng/ml on the day of embryo transfer are associated with lower live birth rate after artificial endometrial preparation: a prospective study

Alyasin

Aghahosseini

Kabiri-Nasab

et al. 2021

Reprod Biol Endocrinol

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“….9-7.4% of cycles that's required cycles cancellation (Mackens et al, 2017). However, controversial opinions regarding ideal serum P around the implantation period, especially at embryo transfer day in FET cycles utilizing different progesterone routes still persist (Coroleu and Gaggiotti-Marre, 2019). Given this controversial backgrounds, we performed a prospective study to observe serum P levels association with dynamic EMT changes on the embryo transfer day especially endometrial compaction and to see if both parameters can pre-dict Ong PR in frozen-thaw cycles of cleavage-stage embryo transfer.…”

Section: Introductionmentioning

confidence: 99%

Endometrial compaction and serum progesterone measurements at the day of embryo transfer cannot predict pregnancy outcomes in frozen-thaw embryo transfer cycles

Jarrah¹,

Al-Obaidi²,

Asadi³

2021

ijrps

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Endometrial receptivity plays a basic role in successful embryo implantation and pregnancy outcomes and can be assessed by many of non-invasive markers. Our study evaluated the impact of two of these markers specifically serum progesterone and endometrial thickness at embryo transfer day in prediction pregnancy outcomes on (60) patients attempting medicated frozen embryo transfer (FET) cycles. All patients were received sequential estrogen & progesterone medications for endometrial preparation then submitted to measurements of endometrial thickness (EMT) by transvaginal-ultrasound (TV-US) & serums progesterone (P) analysis at the embryo transfer day, thereafter day 3 verified-thawed embryos grades (A±B) were transferred. Compacted (decreased) EMT was seen in 48.3% of patients with higher pregnancy rate (PR) of 58.6%t than non-compacted EMT (no change or increased) which was seen in 51.7% of patients with (PR) of 29.0%, (P value=0.021). However ongoing pregnancy rate (Ong PR) not differed significantly between both groups (44.8% in compacted vs 25.8% in non-compacted, P value=0.053), also the means of serum P not differed between pregnant and non-pregnant patients (P value=0.374). ROC curves for Ong PR prediction in relations to endometrial compaction & serum progesterone at embryo transfer day were poor (AUC= 0.630, & AUC=0.576, respectively). This study suggested that endometrial compaction or serum P levels measurements at embryo transfer day were poor predictors for ongoing pregnancy where any kind of EMT changes (decreased or not) seen after P administration not significantly affect pregnancy outcomes in frozen-thaw cycles of cleavage stage embryos transfer.

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Serum progesterone screening for frozen embryo transfer: present and future perspectives

Cited by 2 publications

References 7 publications

Serum progesterone levels greater than 32.5 ng/ml on the day of embryo transfer are associated with lower live birth rate after artificial endometrial preparation: a prospective study

Serum progesterone levels greater than 32.5 ng/ml on the day of embryo transfer are associated with lower live birth rate after artificial endometrial preparation: a prospective study

Endometrial compaction and serum progesterone measurements at the day of embryo transfer cannot predict pregnancy outcomes in frozen-thaw embryo transfer cycles

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