Serum Proinflammatory Cytokine Levels and White Blood Cell Differential Count in Patients with Different Degrees of Severity of Acute Alcoholic Pancreatitis

Panek, Józefa; Kuśnierz-Cabała, Beata; Dolecki, Mirosław; Pietron, Jonathan

doi:10.2478/v10035-012-0038-8

Cited by 10 publications

(6 citation statements)

References 35 publications

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“…Inflammation is the frequently cited mechanism for an increased WBC count. WBC is activated resulting in the release of ROS and other mediators such as inflammatory cytokines [35]. Vitamin C has been found to suppress the inflammatory response by inhibiting NF-κB activity [36].…”

Section: Discussionmentioning

confidence: 99%

Association of antioxidant status and inflammatory markers with metabolic syndrome in Thais

Suriyaprom

Kaewprasert

Putpadungwipon

et al. 2019

J Health Popul Nutr

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BackgroundAn oxidant/antioxidant disequilibrium has been suggested as having a role in the pathogenesis of some diseases. Metabolic syndrome (MS) is significantly associated with cardiovascular disease and type 2 diabetes. The pathogenesis of MS is complex and not well understood. The purposes of the present study were to compare enzymatic and non-enzyme antioxidants, anthropometric, hematological, and biochemical findings between subjects with MS and without MS and to evaluate the relationship between antioxidant status and hematological parameters with the components of MS.MethodsMetabolic syndrome was assessed by using the modified National Cholesterol Education Program, Adult Treatment Panel III criteria. Three hundred Thais, 124 with MS and 176 without MS, were included in the study. Each subject was tested for erythrocyte superoxide dismutase (SOD), glutathione peroxidase, (GPX), catalase (CAT), albumin and vitamin C levels, and hematological findings.ResultsSubjects with MS had lower SOD and CAT levels than those without MS (p < 0.01). Subjects with MS had lower vitamin C and albumin levels than those without MS (p < 0.05). The hematological findings were not significantly different between those with and without MS except the white blood cell (WBC) count which was significantly higher in those with MS. SOD and CAT levels were significantly positively associated with HDL-C levels and negatively associated with components of MS. After adjusting for potential covariates, we found lower SOD and vitamin C levels and higher WBC counts were significantly associated with MS (p < 0.05).ConclusionsThese findings suggest an alteration in antioxidant status and an increase in inflammatory markers are associated with MS and its components among Thais; subjects with MS may be more likely to have oxidative stress problems.

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Section: Discussionmentioning

confidence: 99%

Association of antioxidant status and inflammatory markers with metabolic syndrome in Thais

Suriyaprom

Kaewprasert

Putpadungwipon

et al. 2019

J Health Popul Nutr

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“…These factors have been usually determined in the serum, by total mRNA PCR or in isolated acinar cells in vitro . 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 The origin of the pro- and anti-inflammatory cytokines and inflammasome-associated factors that are evident during the early onset of alcoholic AP has not been completely evaluated, and there is no adequate evidence that those inflammatory mediators colocalize with α -amylase-specific acinar cells in vivo .…”

mentioning

confidence: 99%

Necro-inflammatory response of pancreatic acinar cells in the pathogenesis of acute alcoholic pancreatitis

Gu¹,

Werner²,

Bergmann

et al. 2013

Cell Death Dis

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The role of pancreatic acinar cells in initiating necro-inflammatory responses during the early onset of alcoholic acute pancreatitis (AP) has not been fully evaluated. We investigated the ability of acinar cells to generate pro- and anti-inflammatory mediators, including inflammasome-associated IL-18/caspase-1, and evaluated acinar cell necrosis in an animal model of AP and human samples. Rats were fed either an ethanol-containing or control diet for 14 weeks and killed 3 or 24 h after a single lipopolysaccharide (LPS) injection. Inflammasome components and necro-inflammation were evaluated in acinar cells by immunofluorescence (IF), histology, and biochemical approaches. Alcohol exposure enhanced acinar cell-specific production of TNFα, IL-6, MCP-1 and IL-10, as early as 3 h after LPS, whereas IL-18 and caspase-1 were evident 24 h later. Alcohol enhanced LPS-induced TNFα expression, whereas blockade of LPS signaling diminished TNFα production in vitro, indicating that the response of pancreatic acinar cells to LPS is similar to that of immune cells. Similar results were observed from acinar cells in samples from patients with acute/recurrent pancreatitis. Although morphologic examination of sub-clinical AP showed no visible signs of necrosis, early loss of pancreatic HMGB1 and increased systemic levels of HMGB1 and LDH were observed, indicating that this strong systemic inflammatory response is associated with little pancreatic necrosis. These results suggest that TLR-4-positive acinar cells respond to LPS by activating the inflammasome and producing pro- and anti-inflammatory mediators during the development of mild, sub-clinical AP, and that these effects are exacerbated by alcohol injury.

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“…In the group receiving antibiotics, the median number of WBCs was higher than the group without antibiotics, which showed that leukocytosis might be linked with antibiotic indication in patients. However, in AP, elevated WBCs may not be associated with bacterial infection and may decrease in the first few days for mild AP 13 . Moreover, when analyzing factors involved in WBC reduction efficiency, the study found that using antibiotics or not was not related to this efficiency.…”

Section: Discussionmentioning

confidence: 84%

“…However, in AP, elevated WBCs may not be associated with bacterial infection and may decrease in the first few days for mild AP. 13 Moreover, when analyzing factors involved in WBC reduction efficiency, the study found that using antibiotics or not was not related to this efficiency. It could be seen that elevated WBCs alone might not be associated with infection, and this was also not a specific biological marker for infection in AP.…”

Section: Discussionmentioning

confidence: 96%

Investigation of antibiotic use in patients with acute pancreatitis in a Vietnamese hospital

et al. 2020

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Background and Aim: The aim of this study was to investigate the antibiotics used in patients with acute pancreatitis and evaluate their appropriateness. Methods: We conducted a descriptive cross-sectional study on 136 patients aged 18 years or older who were diagnosed with acute pancreatitis and admitted to a national hospital in Ho Chi Minh City from January 2017 to December 2018. Medical records of patients were reviewed for data analysis, including epidemiological characteristics, pathological characteristics, treatment methods, and treatment effectiveness. Results: There were 69.9% men and 30.1% women with a median age of 49.9 years. The most common etiologies included alcohol (21.3%), gallstones (23.6%), and hypertriglyceridemia (19.9%). The proportions of mild, moderate, and severe disease were 54.4, 39.0, and 6.6%, respectively. Antibiotics were given in 52.2% of patients. Although antibiotic prophylaxis was not recommended, 23.5% of cases used prophylactic antibiotics when there were no suspicion or evidence of infection. Conclusions: Our study suggests that it is necessary to optimize the appropriateness of antibiotic indications for patients with acute pancreatitis.

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Serum Proinflammatory Cytokine Levels and White Blood Cell Differential Count in Patients with Different Degrees of Severity of Acute Alcoholic Pancreatitis

Cited by 10 publications

References 35 publications

Association of antioxidant status and inflammatory markers with metabolic syndrome in Thais

Association of antioxidant status and inflammatory markers with metabolic syndrome in Thais

Necro-inflammatory response of pancreatic acinar cells in the pathogenesis of acute alcoholic pancreatitis

Investigation of antibiotic use in patients with acute pancreatitis in a Vietnamese hospital

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