Serum prolactin and migraine

Tadayon, Hamidreza; Fakharian, Esmail

doi:10.5144/0256-4947.2005.489

Cited by 11 publications

(21 citation statements)

References 11 publications

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“…It was hypothesized that the increased dopaminergic activity is responsible from prodromal, clinical and postdromal symptoms [ 19 , 43 ] and, therefore, a decrease in prolactin levels should be expected during migraine attacks. Conveniently, Masoud and Fakharian [ 44 ] found a significant decrease in prolactin levels during the headache attack in migraineurs. Another study reported high prolactin levels during migraine attack, but the study was carried on subjects who had microprolactinomas [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Soluble CD40 ligand and prolactin levels in migraine patients during interictal period

Güldiken

Demir

et al. 2011

J Headache Pain

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The relationship of migraine with cardiovascular diseases has been clarified by many studies, and currently, migraine is suggested to be a systematic vasculopathy. Inflammation, thrombosis and impaired vascular reactivity are the underlying pathophysiological mechanisms of the vasculopathy. In the present study, we aimed to investigate the relationship between prolactin levels and subclinical atherosclerosis risk factors such as soluble CD40 ligand (sCD40L) and high-sensitivity CRP (hsCRP) in migraine patients during interictal period. Fifty female migraine patients and age-matched 25 female control cases were enrolled in the study. Migraine diagnosis was settled according to the ICHD-II diagnostic criteria. A questionnaire was completed about the existence of vascular risk factors. Serum samples were used to measure sCD40L, hsCRP and prolactin levels. No difference was found between the prolactin levels of the migraine patients and the controls. The sCD40L levels were significantly higher in migraine patients (p < 0.001). High-sensitivity CRP levels showed no difference between the groups. There was no correlation between prolactin, sCD40L, and hs-CRP levels in migraine patients. We consider that the migraine patients are prone to subclinical atherosclerosis, but this tendency is independent of prolactin levels.

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Section: Discussionmentioning

confidence: 99%

Soluble CD40 ligand and prolactin levels in migraine patients during interictal period

Güldiken

Demir

et al. 2011

J Headache Pain

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“…There are reports of suppressed prolactin secretion by dopaminergic agents in women with migraine.. Present information suggests a dopamine deficiency in migraine with super sensitivity of dopaminergic receptors (5) . Endogenous opioids like beta-endorphin, enkephalin and dynorphins are inhibitory neurotransmitters implicated in central regulation.According to vascular theory of Wolff (1) , the vasoconstrictor phase of migraine prodrome is due to neuronal release of Norepinephrine which causes vasoconstriction via alpha-adrenergic receptors.…”

Section: Review Migrainementioning

confidence: 67%

Physiological basis and Mechanism of Headache: Mini Review

Sinha¹

2019

jmscr

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Headache is one of the most common medical complaints of the general population. It could be a major symptom of a serious problem like subarachnoid haemorrhage or psychological factors like day to day tension. The knowledge of physiological basis and mechanism of various types of headaches like Migraine, Cluster headache and Tension type headache has been discussed in this article with recent insights and current understanding with new and old evidences. The present article is an attempt to broadly cover this aspect.

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“…One line of evidence supporting the view that prolactin plays a crucial role in the pathophysiology of migraine is an investigation of prolactin circulatory levels in migraine [ 31 ]. A systematic review followed by a meta-analysis [ 11 ] summarized the available literature since the 1970s on prolactin blood levels in patients with migraine.…”

Section: Prolactin and Migraine: Clinical Researchmentioning

confidence: 99%

A Link Between Migraine and Prolactin: the Way Forward

Gazerani

2021

Future Sci. OA

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Migraine is an incapacitating neurological disorder that predominantly affects women. Sex and other hormones (e.g., oxytocin, and prolactin) may play a role in sexual dimorphic features of migraine. Initially, prolactin was recognized for its modulatory action in milk production and secretion; later, its roles in the regulation of the endocrine, immune and nervous systems were discovered. Higher prolactin levels in individuals with migraine were found in earlier studies, with a female sex-dominant trend. Studies that are more recent have identified that the expression of prolactin receptor in response to neuronal excitability and stress depends on sex with a dominant role in females. These findings have opened up potentials for explanation of sex-related pathophysiology of migraine, but have left some unanswered questions. This focused review examines the past and present of the link between prolactin and migraine, and presents open questions and directions for future experimental and clinical efforts.

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Serum prolactin and migraine

Cited by 11 publications

References 11 publications

Soluble CD40 ligand and prolactin levels in migraine patients during interictal period

Soluble CD40 ligand and prolactin levels in migraine patients during interictal period

Physiological basis and Mechanism of Headache: Mini Review

A Link Between Migraine and Prolactin: the Way Forward

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