Serum prolactin concentrations in canine mammary cancer

Hamilton, JM; Knight, PJ; Beevers, Joel E.; Else, RW

doi:10.1136/vr.102.6.127

Cited by 8 publications

(8 citation statements)

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“…While previous reports indicated no difference in serum PRL level between bitches affected by benign or malignant mammary tumors [32,52], a recent study reported significantly higher serum PRL levels in bitches with malignant tumors [36]. A prospective study already in progress will show if female dogs affected by malignant tumors in fact have increased PRL levels in addition to decreased tumorous PRLR expression.…”

Section: Discussionmentioning

confidence: 90%

“…The role of PRL in tumorigenesis of canine breast cancer is not known to date. Sporadic publications proposed a tumor-promoting role [32,33], and presence of PRLR was documented in canine mammary tumor cells in vivo and in vitro [34,35]. Also were serum and tissue homogenate levels of PRL found to be elevated in dogs with benign and malignant mammary tumors [36].…”

Section: Introductionmentioning

confidence: 99%

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Expression of prolactin receptors in normal canine mammary tissue, canine mammary adenomas and mammary adenocarcinomas

et al. 2012

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BackgroundMammary tumors represent the most common neoplastic disease in female dogs. Recently, the promoting role of prolactin (PRL) in the development of human breast carcinoma has been shown. Possible proliferative, anti-apoptotic, migratory and angiogenic effects of PRL on human mammary cancer cells in vitro and in vivo were suggested. The effects of PRL are mediated by its receptor, and alterations in receptor expression are likely to play a role in tumor development. Currently, not much data is available about prolactin receptor (PRLR) expression in canine mammary tumors. To set the basis for investigations on the role of PRL in mammary tumorigenesis in this species, prolactin receptor expression was evaluated by semi-quantitative real time PCR and immunohistochemistry on 10 formalin-fixed, paraffin-embedded samples each of canine non-neoplastic mammary tissue, mammary adenomas and adenocarcinomas.ResultsThe highest PRLR expression levels were found in normal mammary tissue, while adenomas, and to an even higher degree adenocarcinomas, showed a significant decrease in prolactin receptor expression. Compared to normal tissue, PRLR mRNA was reduced 2.4 fold (p = 0.0261) in adenomas and 4.8 fold (p = 0.008) in adenocarcinomas. PRLR mRNA expression was significantly lower in malignant than in benign lesions (p = 0.0165). Immunohistochemistry demonstrated PRLR expression in all three tissue types with signals mostly limited to epithelial cells.ConclusionsMalignant transformation of mammary tissue was associated with a decline in prolactin receptor expression. Further studies are warranted to address the functional significance of this finding.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Expression of prolactin receptors in normal canine mammary tissue, canine mammary adenomas and mammary adenocarcinomas

et al. 2012

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“…In veterinary medicine, only a small number of published studies reported information about the levels of prolactin in Table 4 Relation of prolactin and steroid hormone levels in tissue homogenates with some clinical characteristics pituitary gland and serum of dogs with mammary tumours [15,[22][23][24] with contradictory and inconclusive results. The present study, performed in 32 bitches with mammary gland tumours and eight female beagles used as a control, shows that dogs with mammary tumours have significantly higher serum PRL levels than healthy dogs (p = 0.01).…”

Section: Discussionmentioning

confidence: 99%

“…Some studies [15,22,23] showed different results with respect to serum and pituitary prolactin levels in dogs with mammary tumours, while other authors supported that this hormone only seems to be essential for maintaining the secretory activity in the canine mammary gland [24].…”

Section: Introductionmentioning

confidence: 99%

Role of steroid hormones and prolactin in canine mammary cancer

Queiroga¹,

Alenza²,

Silván³

et al. 2005

The Journal of Steroid Biochemistry and Molecular Biology

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“…From the late 1990s until today, a wealth of epidemiological and molecular biological studies have established an important, although not yet fully understood role of PRL in the development of hMT . A limited number of studies have addressed a potential role of PRL in cMT development, as discussed later in this review. Comparison between human and canine PRL effect is complicated by the finding that human growth hormones (GHs), as all primate GHs, are able to bind to both PRL receptors (PRLr) and GH receptors (GHr), thereby exerting lactogenic as well as somatogenic activities, whereas canine GHs (as all subprimate species GH) can only bind to GHr …”

Section: Introductionmentioning

confidence: 99%

Prolactin – to be reconsidered in canine mammary tumourigenesis?

Michel

Bley

Kowalewski

et al. 2012

Vet Comparative Oncology

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Mammary tumours represent the most common neoplastic disease of the female dog, and the incidence in female dogs is much higher than in women. Whereas the influence of sexual steroids on breast cancer (BC) development in dogs has been studied, very little is known about the role of prolactin (PRL). New studies show that until recently, the importance of PRL in human BC development and progression has been highly underestimated. PRL plays a role in promoting benign as well as malignant neoplastic cell growth in BC in vitro and in vivo. Sporadic publications proposed a tumour promotor role in the dog. The goal of this review is to summarize our knowledge about PRL and human BC as well as canine mammary tumourigenesis, and propose future research in this area.

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Serum prolactin concentrations in canine mammary cancer

Cited by 8 publications

References 0 publications

Expression of prolactin receptors in normal canine mammary tissue, canine mammary adenomas and mammary adenocarcinomas

Expression of prolactin receptors in normal canine mammary tissue, canine mammary adenomas and mammary adenocarcinomas

Role of steroid hormones and prolactin in canine mammary cancer

Prolactin – to be reconsidered in canine mammary tumourigenesis?

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